Inventors:
Williamson Ziegler Bradford - Ross CA, US
Javier Szwarcberg - San Mateo CA, US
Assignee:
Intermune, Inc. - Brisbane CA
International Classification:
A61K 31/445
Abstract:
Methods are provided for administering pirfenidone to a patient that has exhibited abnormal biomarkers of liver function in response to pirfenidone administration. The methods include administering to a patient pirfenidone at doses lower than the full target dosage for a time period, followed by administering to the patient pirfenidone at the full target dosage. The methods also include administering pirfenidone at the full target dose with no reduction and administering permanently reduced doses of pirfenidone.