Inventors:
William J. Greenlee - Teaneck NJ
Jan ten Broeke - Somerset NJ
Assignee:
Merck & Co., Inc. - Rahway NJ
International Classification:
A61K 3702
C07K 506
C07K 508
C07K 510
Abstract:
Renin-inhibitory di-, tri-, and tetrapeptides of the formula I: A-B-E-G-T-J in which A is heterocyclic, substituted heterocyclic etc; B is --N(A. sup. 1)CH[(CH. sub. 2). sub. 2 R. sup. 3 ]CO--, E is absent or is --N(A. sup. 2)CH[(CH. sub. 2). sub. 2 R. sup. 4 ]CO--; G is ##STR1## and J is --Y--(CH. sub. 2). sub. x [CH(R. sup. 5)]. sub. y --(CH. sub. 2). sub. z --R. sup. 10 and pharmaceutically acceptable salts thereof are disclosed. These compounds inhibit renin and are useful for treating various forms of renin-associated hypertension, hyperaldosteronism and congestive heart failure; compositions containing these renin-inhibitory peptides, optionally with other antihypertensive agents; and methods of treating hypertension, hyperaldosteronism or congestive heart failure or of establishing renin as a causative factor in these problems which employ these novel peptides.
