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James P Unch

from Arroyo Grande, CA
Age ~56
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Also known as:
James Paul Unch, James D Unch, Jame Unch, Jim Unch, James Punch
Phone and address:
257 Ruth Ann Way, Pismo Beach, CA 93420
(805) 481-3827
Related to:
Joanne H Kahane, 76Richard Kahane, 78Richard P KahaneAlexandra L Unch, 47David G Kahane, 50
Connected to:
Angel D Unciano, 29Joseph A Uncles, 57Avraham H Uncyk, 72Irving Uncyk, 78Arturo J Unda, 52Ashley Unda, 35Freddy Unda, 56Richard J Unda, 59Kelvin E Undahl, 64Amit J Unde, 48

James Unch Phones & Addresses

  • 257 Ruth Ann Way, Arroyo Grande, CA 93420 (805) 481-3827
  • Grover Beach, CA
  • 101 Curl Dr, Columbus, OH 43210 (614) 688-9052
  • San Luis Obispo, CA

Resumes

Resumes

James Unch Photo 1

Staff Scientist At Promega

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Position:
Staff scientist at Promega Biosciences
Location:
San Luis Obispo, California Area
Industry:
Biotechnology
Work:
Promega Biosciences since Mar 2011
Staff scientist
Promega Biosciences Mar 2006 - Jun 2011
Senior Research Scientist
Promega Biosciences Jul 2002 - Mar 2006
Research Scientist
The Ohio State University 1998 - 2002
Graduate Student
Education:
The Ohio State University 1996 - 2002
Ph.D., Organic Synthesis California Polytechnic State University-San Luis Obispo 1992 - 1994
B.S., Biochemistry
James Unch Photo 2

James Unch

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Publications

Us Patents

Luminogenic And Fluorogenic Compounds And Methods To Detect Molecules Or Conditions

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US Patent:
8476450, Jul 2, 2013
Filed:
Jul 3, 2008
Appl. No.:
12/217494
Inventors:
James J. Cali - Verona WI, US
William Daily - Santa Maria CA, US
Erika Hawkins - Pembroke, CA
Dieter Klaubert - Arroyo Grande CA, US
Jianquan Liu - Fremont CA, US
Poncho Meisenheimer - San Lius Obispo CA, US
Michael Scurria - San Luis Obispo CA, US
John Shultz - Verona WI, US
James Unch - Arroyo Grande CA, US
Michael P. Valley - Fitchburg WI, US
Keith V. Wood - Mt. Horeb WI, US
Wenhui Zhou - Santa Maria CA, US
Assignee:
Promega Corporation - Madison WI
International Classification:
A61K 31/428
C07D 417/04
C07D 417/14
US Classification:
548178, 514367
Abstract:
A method to detect the presence or amount of at least one molecule in a sample which employs a derivative of luciferin or a derivative of a fluorophore is provided. Compounds and compositions for carrying out the methods of the invention are also provided.

Luminogenic And Fluorogenic Compounds And Methods To Detect Molecules Or Conditions

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US Patent:
20070015790, Jan 18, 2007
Filed:
May 31, 2006
Appl. No.:
11/444145
Inventors:
James Cali - Verona WI, US
William Daily - Santa Maria CA, US
Erika Hawkins - Madison WI, US
Dieter Klaubert - Arroyo Grande CA, US
Jianquan Liu - Fremont CA, US
Poncho Meisenheimer - San Luis Obispo CA, US
Michael Scurria - San Luis Obispo CA, US
John Shultz - Verona WI, US
James Unch - Arroyo Grande CA, US
Michael Valley - Fitchburg WI, US
Keith Wood - Mt. Horeb WI, US
Wenhui Zhou - Santa Maria CA, US
International Classification:
C07D 417/04
A61K 31/4709
A61K 31/428
A61K 31/427
US Classification:
514314000, 514367000, 514365000, 546176000, 548181000
Abstract:
A method to detect the presence or amount of at least one molecule in a sample which employs a derivative of luciferin or a derivative of a fluorophore is provided.

Methods To Quench Light From Optical Reactions

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US Patent:
20080248511, Oct 9, 2008
Filed:
Mar 26, 2008
Appl. No.:
12/056073
Inventors:
William Daily - Sant Maria CA, US
Erika Hawkins - Pembal, CA
Dieter Klaubert - Arroyo Grande CA, US
Mark McDougall - Arroyo Grande CA, US
James Unch - Arroyo Grande CA, US
Keith V. Wood - Mt. Horeb WI, US
Wenhui Zhou - Santa Maria CA, US
Ji Zhu - Ossining NY, US
International Classification:
C07D 209/16
C12Q 1/66
US Classification:
435 8, 548503
Abstract:
The present invention relates to single and dual reporter luminescence assays utilizing reagents to quench an optical, e.g., an enzyme-mediated luminescence, reaction. In one embodiment of the invention, a reagent is added to an assay which selectively quenches a first enzyme-mediated luminescence reaction without affecting a subsequent distinct enzyme-mediated luminescent reaction(s). An assay kit containing one or more selective quench reagents, and compositions comprising the quench reagent(s), are also provided.

Coelenterazine Derivatives And Methods Of Using Same

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US Patent:
20120107849, May 3, 2012
Filed:
Nov 2, 2011
Appl. No.:
13/287519
Inventors:
Dieter H. Klaubert - Arroyo Grande CA, US
Poncho Meisenheimer - San Luis Obispo CA, US
James Unch - Arroyo Grande CA, US
Wenhui Zhou - Santa Maria CA, US
International Classification:
C12Q 1/66
C07D 471/04
US Classification:
435 8, 544350
Abstract:
The invention provides coelenterazine derivatives which are substrates for a non-luminescent enzyme and a pro-substrate for a luminescent enzyme. The invention also provides a method of using the derivatives.

Novel Coelenterazine Substrates And Methods Of Use

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US Patent:
20120117667, May 10, 2012
Filed:
Nov 2, 2011
Appl. No.:
13/287992
Inventors:
Dieter H. Klaubert - Arroyo Grande CA, US
Poncho Meisenheimer - San Luis Obispo CA, US
James Unch - Arroyo Grande CA, US
International Classification:
C12Q 1/66
A61K 49/00
C07D 487/04
US Classification:
800 3, 544350, 435 8
Abstract:
An isolated polynucleotide encoding a modified luciferase polypeptide and novel coelenterazine-based substrates. The OgLuc variant polypeptide has at least 60% amino acid sequence identity to SEQ ID NO: 1 and at least one amino acid substitution at a position corresponding to an amino acid in SEQ ID NO: 1. The OgLuc variant polypeptide has at least one of enhanced luminescence, enhanced signal stability, and enhanced protein stability relative to the corresponding polypeptide of the wild-type luciferase.

Detection Of Hydrogen Peroxide

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US Patent:
20130045497, Feb 21, 2013
Filed:
Aug 16, 2012
Appl. No.:
13/587387
Inventors:
Dieter Klaubert - Arroyo Grande CA, US
John Shultz - Verona WI, US
James Unch - Arroyo Grande CA, US
Michael P. Valley - Fitchburg WI, US
Hui Wang - San Luis Obispo CA, US
Wenhui Zhou - San Luis obispo CA, US
Assignee:
Promega Corporation - Madison WI
International Classification:
C07F 5/02
G01N 21/76
US Classification:
435 8, 548110, 544229
Abstract:
The present invention provides compounds useful for detection of hydrogen peroxide and methods of using same.

Activation Of Bioluminescence By Structural Complementation

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US Patent:
20200292534, Sep 17, 2020
Filed:
Apr 17, 2020
Appl. No.:
16/851841
Inventors:
- Madison WI, US
Lance Encell - Fitchburg WI, US
Mary Hall - Waunakee WI, US
Keith Wood - Mt. Horeb WI, US
Monika Wood - Mt. Horeb WI, US
Marie Schwinn - Madison WI, US
Brock F. Binkowski - Sauk City WI, US
Hicham Zegzouti - Madison WI, US
Nidhi Nath - Madison WI, US
Subhanjan Mondal - Middleton WI, US
Said Goueli - Fitchburg WI, US
Poncho Meisenheimer - San Luis Obispo CA, US
Thomas Kirkland - Atascadero CA, US
James Unch - Arroyo Grande CA, US
Dileep K. Pulukkunat - Middleton WI, US
Matthew Robers - Madison WI, US
Melanie Dart - Madison WI, US
Thomas Machleidt - Madison WI, US
International Classification:
G01N 33/533
C07K 14/435
C12Q 1/66
C07K 7/08
C12N 9/02
G01N 33/542
G01N 33/58
A61K 51/08
Abstract:
Provided herein are compositions and methods for the assembly of a bioluminescent complex from two or more non-luminescent (e.g., substantially non-luminescent) peptide and/or polypeptide units. In particular, bioluminescent activity is conferred upon a non-luminescent polypeptide via structural complementation with another, complementary non-luminescent peptide.

Luminogenic And Fluorogenic Compounds And Methods To Detect Molecules Or Conditions

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US Patent:
20190031629, Jan 31, 2019
Filed:
Aug 22, 2018
Appl. No.:
16/109146
Inventors:
- Madison WI, US
William Daily - Santa Maria CA, US
Erika Hawkins - Madison WI, US
Dieter Klaubert - Arroyo Grande CA, US
Jianquan Liu - Fremont CA, US
Poncho Meisenheimer - San Luis Obispo CA, US
Michael Scurria - San Luis Obispo CA, US
John W. Shultz - Verona WI, US
James Unch - Arroyo Grande CA, US
Michael P. Valley - Fitchburg WI, US
Keith V. Wood - Mount Horeb WI, US
Wenhui Zhou - San Luis Obispo CA, US
International Classification:
C07D 277/66
C07D 417/04
C09B 57/00
C07F 9/6558
C07D 277/68
C09B 11/24
C07D 493/10
C12Q 1/66
C07D 417/14
C09B 19/00
C09B 57/02
C07D 311/16
Abstract:
A method to detect the presence or amount of at least one molecule in a sample which employs a derivative of luciferin or a derivative of a fluorophore is provided. Compounds and compositions for carrying out the methods of the invention are also provided.
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James P Unch from Arroyo Grande, CA, age ~56 Get Report