James Francis Caffrey

20030105332, Jun 5, 2003

Mar 25, 2002

10/106513

Anthony Booth - Chester NJ, US
James Caffrey - Burleson TX, US

C07D213/28
C07D213/54

546/339000, 546/336000, 564/050000, 564/349000

The present invention provides stereoscopically-pure diastereomers of Formula I: In a preferred embodiment, the stereoisomers of the present invention are of Formula II, depicted below: R, Rand le are independently H, OH, OCH, CHOH, NHCONH, NH, halogen or CF, and Ris pyridine, or an amine which may be substituted with hydrogen, lower alkyl, lower alkylenearyl, lower alkylenephenyl, lower alkylenehydroxyphenyl, lower alkyleneamine, lower alkyleneaminoaryl, lower alkylaminohydroxyphenyl, or a similar functional group. TV is hydrogen, hydroxyl or methyl; Ris hydrogen, lower alkyl, lower alkylenaryl, lower alkylenephenyl, lower alkylenehydroxyphenyl, lower alkyleneamine, lower alkyleneaminoaryl, lower alkylaminohydroxyphenyl, and the like. For both Formula I and Formual II, the firs carbon on the side chain progressing from the ring is preferably in the R-configuration. The second carbon atom on the side chain of Formula II, which is attached to IV, may or may not be a chiral center. However, when the second carbon atom is a chiral center, it is preferably in the S-configuration. The present invention contemplates each stereoisomer of Formula I and II in substantially-pure form. The present invention also provides methods of relieving nasal, sinus and bronchial congestion and of treating attention deficit hyperactivity disorder and obesity. The present stereoisomers may also be used to induce pupil dilation. These methods include administering to a mammal a composition containing a therapeutically effective amount of a stereoscopically-pure stereoisomer of Formula I or II with a pharmaceutically acceptable excipient.

20130086431, Apr 4, 2013

Nov 27, 2012

13/686389

International Business Machines Corporation - Armonk NY, US
JAMES M. CAFFREY - WOODSTOCK NY, US
KEYUR PATEL - POUGHKEEPSIE NY, US
ASPEN L. PAYTON - BYRON MN, US

INTERNATIONAL BUSINESS MACHINES CORPORATION - Armonk NY

G06F 11/30

714 471

Techniques are described for monitoring a performance metric. A multiple modeling approach is used to improve predictive analysis by avoiding the issuance of warnings during spikes which occur as a part of normal system processing. This approach increases the accuracy of predictive analytics on a monitored computing system, does not require creating rules defining periodic processing cycles, reduces the amount of data required to perform predictive modeling, and reduces the amount of CPU required to perform predictive modeling.

20130091385, Apr 11, 2013

Oct 19, 2012

13/655520

International Business Machines Corporation - Armonk NY, US
James M. Caffrey - Woodstock NY, US
Juliet C. Candee - Danbury CT, US
Aspen L. Payton - Byron MN, US
William R. Richardson - Fishkill NY, US

INTERNATIONAL BUSINESS MACHINES CORPORATION - Armonk NY

G06F 11/22

714 37, 714E11148

A computing system resource recovery method can include identifying a resource manager associated with a computing transaction, classifying the computing transaction to determine a predetermined metric, measuring an actual metric of the computing transaction, comparing the predetermined metric to the actual metric to detect abnormal behavior in the transaction and modeling the abnormal behavior to determine how the resource manager is affected by the abnormal behavior.

20130097109, Apr 18, 2013

Dec 5, 2012

13/705286

International Business Machines Corporation - Armonk NY, US
JAMES M. CAFFREY - WOODSTOCK NY, US
ASPEN L. PAYTON - BYRON MN, US

INTERNATIONAL BUSINESS MACHINES CORPORATION - Armonk NY

G06N 5/02

706 46

Techniques are described for determining what node of a classification and regression tree (CART) should be used by a predictive analysis application. A first approach is to use a standard deviation of the data at a given the level of the CART to determine whether data in the next, lower node is more consistent than the data in the current node. A second approach is to measure a correlation between data points in a given node and the time at which each point was sampled (or other correlation metric) to identify a preferred node.

61226319, Sep 19, 2000

Mar 28, 1997

8/825303

Robert R. Berbec - New York NY
John L. Brady - Apex NC
James M. Caffrey - Woodstock NY
Joanne T. Crimi - Highland NY
Arthur P. Fenaroli - Rhinebeck NY
Matthew C. Iatridis - Woodstock NY
Gary S. Puchkoff - Poughkeepsie NY
Roberto J. Sanchez - Poughkeepsie NY
Madeline R. Whalen - Hyde Park NY
Joseph A. Williams - Cary NC

International Business Machines Corporation - Armonk NY

G06F 1314

707 9

A method and apparatus for providing dynamically controlling access to files in a client/server system. A client wanting access to a file first requests a token from an object server. The object server generates the token as a function of the file name and ephemeral information and provides the token to both the client and the file system. Upon receiving the token from the object server, the client presents an access request to the file system, using the token rather than the file name as an identifier. The file system compares the received identifier with the file names in the specified directory as well as with a list of valid tokens that it maintains. If the identifier corresponds to a valid token for a file in the directory, the access request is granted. Otherwise, the access request is denied. The procedure is transparent to the client, which uses the token in the same manner as it would use a regular file name.