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Howard J Kirchick

from Northville, MI
Age ~75
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Related to:
Diane P Heimberg, 76Susana Z GuzmanSusan Cordiss Heinberg Moore, 78
Connected to:
Adam M Kirchler, 40Douglas S Kirchman, 67Paul E Kirchmann, 81Robert M Kirchmaier, 61Brian K Kirchmeyer, 44Jared B Kirchmer, 48Randal L Kirchmeier, 53Ruth Kirchmeier, 88Regina D Kirchnavy, 63Aaron J Kirchner, 47

Howard Kirchick Phones & Addresses

  • 16538 Yellowstone Dr, Northville, MI 48168 (248) 719-7376
  • 5449 Panoramic Ln, San Diego, CA 92121 (858) 546-1613 (858) 546-1614
  • 10292 Wateridge Cir, San Diego, CA 92121 (858) 546-1614
  • 108 Mustang Island Trl, Georgetown, TX 78633 (512) 819-0660
  • Delray Beach, FL
  • Attleboro, MA
  • 16538 Yellowstone Dr, Northville, MI 48168 (858) 546-1614

Work

Company: Free lance Jul 2014 Position: Retired, part-time consultant

Education

Degree: Doctorates, Doctor of Philosophy School / High School: University of Michigan 1973 to 1978 Specialities: Zoology, Philosophy

Skills

Fda • Immunoassays • Medical Devices • Biotechnology • Lifesciences • Validation • Clinical Research • Infectious Diseases • Hardware Diagnostics • Oncology • Glp • Clinical Trials

Industries

Hospital & Health Care

Resumes

Resumes

Howard Kirchick Photo 1

Howard Kirchick

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Location:
16538 Yellowstone Dr, Northville, MI 48168
Industry:
Hospital & Health Care
Work:
Free Lance
Retired, Part-Time Consultant
Biosite 1998 - Jul 2014
Director, Scientific Affairs
Baxter Diagnostics 1983 - 1993
Section Manager
Education:
University of Michigan 1973 - 1978
Doctorates, Doctor of Philosophy, Zoology, Philosophy
Skills:
Fda
Immunoassays
Medical Devices
Biotechnology
Lifesciences
Validation
Clinical Research
Infectious Diseases
Hardware Diagnostics
Oncology
Glp
Clinical Trials

Publications

Us Patents

Diagnostic Markers Of Acute Coronary Syndrome And Methods Of Use Thereof

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US Patent:
7358055, Apr 15, 2008
Filed:
Aug 17, 2005
Appl. No.:
11/205571
Inventors:
Gunars Valkirs - Escondido CA, US
Jeffrey Dahlen - San Diego CA, US
Howard Kirchick - San Diego CA, US
Kenneth F. Buechler - San Diego CA, US
Assignee:
Biosite, Inc. - San Diego CA
International Classification:
G01N 33/53
US Classification:
435 71
Abstract:
The present invention relates to methods for the diagnosis and evaluation of acute coronary syndromes. In particular, patient test samples are analyzed for the presence and amount of members of a panel of markers comprising one or more specific markers for myocardial injury and one or more non-specific markers for myocardial injury. A variety of markers are disclosed for assembling a panel of markers for such diagnosis and evaluation. In various aspects, the invention provides methods for the early detection and differentiation of stable angina, unstable angina, and myocardial infarction. Invention methods provide rapid, sensitive and specific assays that can greatly increase the number of patients that can receive beneficial treatment and therapy, reduce the costs associated with incorrect diagnosis, and provide important information about the prognosis of the patient.

Diagnostic Markers Of Stroke And Cerebral Injury And Methods Of Use Thereof

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US Patent:
7427490, Sep 23, 2008
Filed:
Aug 20, 2002
Appl. No.:
10/225082
Inventors:
Gunars E. Valkirs - Escondido CA, US
Jeffrey R. Dahlen - San Diego CA, US
Howard J. Kirchick - San Diego CA, US
Kenneth F. Buechler - San Diego CA, US
Assignee:
Biosite Incorporated - San Diego CA
International Classification:
G01N 33/00
US Classification:
435 792, 435 71, 436501, 436811
Abstract:
The present invention relates to methods for the diagnosis and evaluation of stroke and transient ischemic attacks. In a particular aspect, patient samples are analyzed for the presence or amount of a panel of markers comprising one or more specific markers for cerebral injury and one or more non-specific markers for cerebral injury. In an alternative aspect, samples are analyzed for B-type natriuretic peptide. A variety of markers are disclosed for assembling a panel for such diagnosis and evaluation. In various aspects, the invention provides methods for early detection and differentiation of stroke types and transient ischemic attacks, for determining the prognosis of a patient presenting with stroke symptoms, and identifying a patient at risk for cerebral vasospasm. Invention methods provide rapid, sensitive and specific assays to greatly increase the number of patients that can receive beneficial stroke treatment and therapy, and reduce the costs associated with incorrect stroke diagnosis.

Diagnostic Markers Of Stroke And Cerebral Injury And Methods Of Use Thereof

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US Patent:
7608406, Oct 27, 2009
Filed:
Jun 23, 2004
Appl. No.:
10/875800
Inventors:
Gunars E. Valkirs - Escondido CA, US
Jeffrey R. Dahlen - San Diego CA, US
Howard J. Kirchick - San Diego CA, US
Kenneth F. Buechler - Rancho Santa Fe CA, US
Assignee:
Biosite, Inc. - Waltham MA
International Classification:
G01N 33/53
US Classification:
435 71, 435 721, 436501, 436518, 424 91
Abstract:
The present invention relates to methods for the diagnosis and evaluation of stroke and transient ischemic attacks. A variety of markers are disclosed for assembling a panel for such diagnosis and evaluation. In various aspects, the invention provides methods for early detection and differentiation of stroke types and transient ischemic attacks, for determining the prognosis of a patient presenting with stroke symptoms, and identifying a patient at risk for cerebral vasospasm. Invention methods provide rapid, sensitive and specific assays to greatly increase the number of patients that can receive beneficial stroke treatment and therapy, and reduce the costs associated with incorrect stroke diagnosis.

Diagnostic Markers Of Acute Coronary Syndrome And Methods Of Use Thereof

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US Patent:
7361473, Apr 22, 2008
Filed:
May 4, 2002
Appl. No.:
10/139086
Inventors:
Gunars Valkirs - Escondido CA, US
Jeffrey Dahlen - San Diego CA, US
Kenneth F. Buechler - San Diego CA, US
Howard Kirchick - San Diego CA, US
Assignee:
Biosite, Incorporated - San Diego CA
International Classification:
G01N 33/53
US Classification:
435 71
Abstract:
The present invention relates to methods for the diagnosis and evaluation of acute coronary syndromes. In particular, patient test samples are analyzed for the presence and amount of members of a panel of markers comprising one or more specific markers for myocardial injury and one or more non-specific markers for myocardial injury. A variety of markers are disclosed for assembling a panel of markers for such diagnosis and evaluation. In various aspects, the invention provides methods for the early detection and differentiation of stable angina, unstable angina, and myocardial infarction. Invention methods provide rapid, sensitive and specific assays that can greatly increase the number of patients that can receive beneficial treatment and therapy, reduce the costs associated with incorrect diagnosis, and provide important information about the prognosis of the patient.

Diagnostic Markers Of Stroke And Cerebral Injury And Methods Of Use Thereof

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US Patent:
20030199000, Oct 23, 2003
Filed:
Feb 20, 2003
Appl. No.:
10/371149
Inventors:
Gunars Valkirs - Escondido CA, US
Jeffery Dahlen - San Diego CA, US
Howard Kirchick - San Diego CA, US
Kenneth Buechler - Rancho Santa Fe CA, US
International Classification:
G01N033/53
C12M001/34
US Classification:
435/007100, 435/287200
Abstract:
The present invention relates to methods for the diagnosis and evaluation of stroke and transient ischemic attacks. A variety of markers are disclosed for assembling a panel for such diagnosis and evaluation. In various aspects, the invention provides methods for early detection and differentiation of stroke types and transient ischemic attacks, for determining the prognosis of a patient presenting with stroke symptoms, and identifying a patient at risk for cerebral vasospasm. Invention methods provide rapid, sensitive and specific assays to greatly increase the number of patients that can receive beneficial stroke treatment and therapy, and reduce the costs associated with incorrect stroke diagnosis.

System And Method For Identifying A Panel Of Indicators

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US Patent:
20040121350, Jun 24, 2004
Filed:
Apr 8, 2003
Appl. No.:
10/410572
Inventors:
Joseph Anderberg - Encinitas CA, US
Kenneth Buechler - Rancho Santa Fe CA, US
Paul McPherson - Encinitas CA, US
Howard Kirchick - San Diego CA, US
Jeffrey Dahlen - San Diego CA, US
Assignee:
Biosite Incorporated
International Classification:
C12Q001/68
G01N033/53
G06F019/00
G01N033/48
G01N033/50
US Classification:
435/006000, 435/007100, 702/019000
Abstract:
The present invention relates to methods and system for the diagnosis diseases or conditions. In a particular aspect, a disclosed method for determining a panel includes calculating a panel response for each patient in a set of diseased patients and in a set of non-diseased patients. The panel response is a function of the value of each of a plurality of markers in a panel of markers. The method also includes calculating a value for an objective function. The objective function is indicative of the effectiveness of the panel. The steps of calculating a panel response for each patient and calculating a value for an objective function are iterated by varying at least one of the parameters relating to the panel response function and a sense of each marker to facilitate optimization of the objective function. The objective function may be a measure of an overlap of panel responses of diseased patients and panel responses of non-diseased patients. The contribution of each marker to the objective function may be determined, and the panel size may be reduced by removing the poorest markers. Thus, an optimum panel of markers and an optimal panel response function for the diagnosis of a disease or condition may be determined.

Method And System For Disease Detection Using Marker Combinations

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US Patent:
20040126767, Jul 1, 2004
Filed:
Dec 27, 2002
Appl. No.:
10/331127
Inventors:
Joseph Anderberg - Encinitas CA, US
Kenneth Buechler - Rancho Santa Fe CA, US
Paul McPherson - Encinitas CA, US
Howard Kirchick - San Diego CA, US
Jeffrey Dahlen - San Diego CA, US
Assignee:
Biosite Incorporated
International Classification:
C12Q001/68
G06F019/00
G01N033/48
G01N033/50
US Classification:
435/006000, 702/020000
Abstract:
The present invention relates to methods and system for the diagnosis diseases or conditions. In a particular aspect, a disclosed method for determining a panel includes calculating a panel response for each patient in a set of diseased patients and in a set of non-diseased patients. The panel response is a function of the value of each of a plurality of markers in a panel of markers. The method also includes calculating a value for an objective function. The objective function is indicative of the effectiveness of the panel. The steps of calculating a panel response for each patient and calculating a value for an objective function are iterated by varying at least one of the parameters relating to the panel response function and a sense of each marker to facilitate optimization of the objective function. The objective function may be a measure of an overlap of panel responses of diseased patients and panel responses of non-diseased patients. The contribution of each marker to the objective function may be determined, and the panel size may be reduced by removing the poorest markers. Thus, an optimum panel of markers and an optimal panel response function for the diagnosis of a disease or condition may be determined.

Diagnostic Markers Of Stroke And Cerebral Injury And Methods Of Use Thereof

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US Patent:
20040209307, Oct 21, 2004
Filed:
Sep 26, 2003
Appl. No.:
10/673077
Inventors:
Gunars Valkirs - Escondido CA, US
Jeffrey Dahlen - San Diego CA, US
Howard Kirchick - San Diego CA, US
Kenneth Buechler - San Diego CA, US
Assignee:
Biosite Incorporated
International Classification:
G01N033/53
US Classification:
435/007100
Abstract:
The present invention relates to methods for the diagnosis and evaluation of stroke and transient ischemic attacks. A variety of markers are disclosed for assembling a panel for such diagnosis and evaluation. In various aspects, the invention provides methods for early detection and differentiation of stroke types and transient ischemic attacks, for determining the prognosis of a patient presenting with stroke symptoms, and identifying a patient at risk for cerebral vasospasm. Invention methods provide rapid, sensitive and specific assays to greatly increase the number of patients that can receive beneficial stroke treatment and therapy, and reduce the costs associated with incorrect stroke diagnosis.
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Howard J Kirchick from Northville, MI, age ~75 Get Report