Inventors:
Jurgen Schmidt - Los Alamos NM, US
Anne Boyer - Atlanta GA, US
Suzanne Kalb - Atlanta GA, US
Hercules Moura - Tucker GA, US
John Barr - Suwannee GA, US
Adrian Woolfitt - Atlanta GA, US
International Classification:
G01N 33/53
Abstract:
The present invention is directed to a method for detecting the presence of clostridial neurotoxins in a sample by mixing a sample with a peptide that can serve as a substrate for proteolytic activity of a clostridial neurotoxin; and measuring for proteolytic activity of a clostridial neurotoxin by a mass spectroscopy technique. In one embodiment, the peptide can have an affinity tag attached at two or more sites.