Inventors:
Ranga Nathan - Danville CA
Henryk Cudny - Concord CA
Assignee:
Celtrix Pharmaceuticals, Inc. - Santa Clara CA
International Classification:
C07K 100
C07K 1400
C12N 1500
Abstract:
Methods are disclosed for increasing the yields of recombinant proteins. Addition of one or more protective agents, such as a sulfated compound (including heparin, heparin sulfate, sodium dodecyl sulfate, and the like), hyaluronic acid or deoxycholate, to recombinant protein production processes is disclosed. Addition of protective agents to the recombinant production process results in increased yields of recombinant proteins.