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Gurkan Guntas

from Newton, MA
Age ~47
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Also known as:
Gurkan Gurkan
Related to:
Demet Guntas, 48
Connected to:
Alice P Gunter, 75Amanda Gunter, 42Arthur R Gunter, 48Billie J Gunter, 60Carma L Gunter, 57Carol L Gunter, 55Casandra A Gunter, 36Charlotte Gunter, 88Claire E Gunter, 48Colleen M Gunter, 90

Gurkan Guntas Phones & Addresses

  • Newton, MA
  • 8 Poor Farm Rd, Harvard, MA 01451
  • Arlington, MA
    • s
  • 101 Hanford Rd, Chapel Hill, NC 27516
  • Carrboro, NC
  • Baltimore, MD

Publications

Us Patents

Methods For Making And Using Molecular Switches Involving Circular Permutation

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US Patent:
20130149785, Jun 13, 2013
Filed:
Nov 19, 2012
Appl. No.:
13/680751
Inventors:
The Johns Hopkins University - Baltimore MD, US
Gurkan Guntas - Carrboro NC, US
Assignee:
THE JOHNS HOPKINS UNIVERSITY - Baltimore MD
International Classification:
C12N 15/62
C12N 15/65
US Classification:
435455, 435 9141, 435485, 435488, 435476, 435483, 435468, 435375
Abstract:
The invention provides molecular switches which couple external signals to functionality, and combinatorial methods of making and using the same involving circular permutation of nucleic acid and amino acid sequences. The switches according to the invention can be used, for example, to regulate gene transcription, target drug delivery to specific cells, transport drugs intracellularly, control drug release, provide conditionally active proteins, perform metabolic engineering, and modulate cell signaling pathways. Libraries comprising the switches, expression vectors and host cells for expressing the switches are also provided.

Multifunctional Molecules That Bind To Cd33 And Uses Thereof

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US Patent:
20230102344, Mar 30, 2023
Filed:
Jun 30, 2022
Appl. No.:
17/855335
Inventors:
- Cambridge MA, US
Gurkan Guntas - Newton MA, US
Peter Marek - Hudson MA, US
Andreas Loew - Boston MA, US
International Classification:
C07K 16/28
C12N 15/62
C07K 14/55
C07K 14/54
C07K 14/57
A61K 39/395
A61K 45/06
A61P 35/00
Abstract:
Multifunctional molecules that include i) an antigen binding domain that binds to CD33; and one or both of: an immune cell engager (e.g., chosen from a T cell engager, an NK cell engager, a B cell engager, a dendritic cell engager, or a macrophage cell engager) or a cytokine molecule. Additionally disclosed are nucleic acids encoding the same, methods of producing the aforesaid molecules, and methods of treating a cancer using the aforesaid molecules.

Multifunctional Molecules That Bind To T Cell Related Cancer Cells And Uses Thereof

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US Patent:
20210380682, Dec 9, 2021
Filed:
Aug 13, 2021
Appl. No.:
17/402325
Inventors:
- Cambridge MA, US
Nidhi Malhotra - Boston MA, US
Madan Katragadda - Acton MA, US
Seng-Lai Tan - Sudbury MA, US
Jonathan Hsu - Waltham MA, US
Brian Edward Vash - Cambridge MA, US
Stephanie J. Maiocco - Arlington MA, US
Peter Marek - Hudson MA, US
Gurkan Guntas - Newton MA, US
International Classification:
C07K 16/28
A61P 35/00
Abstract:
Multifunctional molecules that include i) an antigen binding domain that binds to a T cell receptor beta chain constant domain 1 or T cell receptor beta chain constant domain 2; and one, two or all of: (ii) an immune cell engager (e.g., chosen from an NK cell engager, a T cell engager, a B cell engager, a dendritic cell engager, or a macrophage cell engager); (iii) a cytokine molecule or cytokine inhibitor molecule; (iv) a death receptor signal enhancer; and/or (v) a stromal modifying moiety are disclosed. Additionally disclosed are nucleic acids encoding the same, methods of producing the aforesaid molecules, and methods of treating a cancer using the aforesaid molecules.

Antibodies Specific For Gucy2C And Uses Thereof

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US Patent:
20200010566, Jan 9, 2020
Filed:
May 21, 2019
Appl. No.:
16/417863
Inventors:
- New York NY, US
Gurkan Guntas - Harvard MA, US
Madan Katragadda - Acton MA, US
Divya Mathur - Scarsdale NY, US
Adam Reid Root - Byfield MA, US
Lidia Mosyak - Newton MA, US
Edward Roland LaVallie - Harvard MA, US
Assignee:
Pfizer Inc. - New York NY
International Classification:
C07K 16/40
A61P 35/00
Abstract:
The present invention provides novel antibodies that specifically bind to GUCY2c and uses thereof in the treatment of cancer. The present invention further provides novel bispecific antibodies comprising such antibodies and uses thereof in the treatment of cancer.

Methods For Making And Using Molecular Switches Involving Circular Permutation

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US Patent:
20140249302, Sep 4, 2014
Filed:
Jan 27, 2014
Appl. No.:
14/165064
Inventors:
- Baltimore MD, US
Gurkan Guntas - Carrboro NC, US
Assignee:
THE JOHNS HOPKINS UNIVERSITY - Baltimore MD
International Classification:
C07K 14/00
US Classification:
536 234
Abstract:
The invention provides molecular switches which couple external signals to functionality, and combinatorial methods of making and using the same involving circular permutation of nucleic acid and amino acid sequences. The switches according to the invention can be used, for example, to regulate gene transcription, target drug delivery to specific cells, transport drugs intracellularly, control drug release, provide conditionally active proteins, perform metabolic engineering, and modulate cell signaling pathways. Libraries comprising the switches, expression vectors and host cells for expressing the switches are also provided.
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Gurkan Guntas from Newton, MA, age ~47 Get Report