Inventors:
O John Semmes - Newport News VA, US
Gunjan Malik - Helotes TX, US
Michael D. Ward - Chesapeake VA, US
Assignee:
Eastern Virginia Medical School - Norfolk VA
International Classification:
G01N 33/574
C07K 7/00
Abstract:
The present invention provides a protein-based biomarker, ApoA-II isoform, that is useful in determining prostate cancer status in a patient. In particular, the biomarker of this invention is useful to classify a biological sample as prostate cancer or non-prostate cancer. The ability of ApoA-II to detect disease in patients with a normal prostate-specific antigen (PSA) makes the biomarker of this invention useful in identifying indolent disease. The biomarker can be detected by SELDI mass spectrometry, HPLC, PAGE and Western blotting.
