Resumes
Resumes
Gregg Keaney Phones & Addresses
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34 Robbins Rd, Lexington, MA 02421 (203) 676-5545
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Belmont, MA
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Cambridge, MA
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120 Bishop St, New Haven, CT 06511 (203) 785-0310
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122 Bishop St, New Haven, CT 06511
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34 Daventry Ct, Lynnfield, MA 01940 (781) 334-4735
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Medford, MA
Publications
Us Patents
Compounds And Methods For Inhibiting The Interaction Of Bcl Proteins With Binding Partners
View pageUS Patent:
8178690, May 15, 2012
Filed:
Apr 19, 2011
Appl. No.:
13/089530
Inventors:
Alfredo C. Castro - Winchester MA, US
Kristopher M. Depew - Acton MA, US
Michael J. Grogan - Winchester MA, US
Charles W. Johannes - Newbury MA, US
Edward B. Holson - Newton Highlands MA, US
Brian T. Hopkins - Newton MA, US
Gregg F. Keaney - Belmont MA, US
Nii O. Koney - New York NY, US
Tao Liu - Ashland MA, US
David A. Mann - Madison WI, US
Marta Nevalainen - Quincy MA, US
Stephane Peluso - Somerville MA, US
Lawrence Blas Perez - Hopkinton MA, US
Daniel A. Snyder - Somerville MA, US
Thomas T. Tibbitts - Westford MA, US
Kristopher M. Depew - Acton MA, US
Michael J. Grogan - Winchester MA, US
Charles W. Johannes - Newbury MA, US
Edward B. Holson - Newton Highlands MA, US
Brian T. Hopkins - Newton MA, US
Gregg F. Keaney - Belmont MA, US
Nii O. Koney - New York NY, US
Tao Liu - Ashland MA, US
David A. Mann - Madison WI, US
Marta Nevalainen - Quincy MA, US
Stephane Peluso - Somerville MA, US
Lawrence Blas Perez - Hopkinton MA, US
Daniel A. Snyder - Somerville MA, US
Thomas T. Tibbitts - Westford MA, US
Assignee:
Infinity Pharmaceuticals, Inc. - Cambridge MA
International Classification:
C07D 261/02
A61K 31/42
A61K 31/42
US Classification:
548240, 514378
Abstract:
The invention relates to isoxazolidine containing compounds that bind to bcl proteins and inhibit Bcl function. The compounds may be used for treating and modulating disorders associated with hyperproliferation, such as cancer.
Triazoles As Inhibitors Of Fatty Acid Synthase
View pageUS Patent:
8450350, May 28, 2013
Filed:
May 5, 2011
Appl. No.:
13/101970
Inventors:
Adilah Bahadoor - Cambridge MA, US
Alfredo C. Castro - Winchester MA, US
Lawrence K. Chan - Brookline MA, US
Gregg F. Keaney - Lexington MA, US
Marta Nevalainen - Weymouth MA, US
Vesa Nevalainen - Weymouth MA, US
Stephane Peluso - Brookline MA, US
Thomas T. Tibbitts - Westford MA, US
Alfredo C. Castro - Winchester MA, US
Lawrence K. Chan - Brookline MA, US
Gregg F. Keaney - Lexington MA, US
Marta Nevalainen - Weymouth MA, US
Vesa Nevalainen - Weymouth MA, US
Stephane Peluso - Brookline MA, US
Thomas T. Tibbitts - Westford MA, US
Assignee:
Infinity Pharmaceuticals, Inc. - Cambridge MA
International Classification:
A61K 31/41
A61K 31/4192
C07D 249/00
C07D 249/06
A61K 31/4192
C07D 249/00
C07D 249/06
US Classification:
514359, 548255
Abstract:
Provided herein are triazole FASN inhibitors of the formula (I):Also provided herein are pharmaceutical compositions of the compounds provided herein as well as methods of their use for the treatment of various disorders such as hyperproliferative disorders, inflammatory disorders, obesity-related disorders and microbial infections.
Tetrazolones As Inhibitors Of Fatty Acid Synthase
View pageUS Patent:
8546432, Oct 1, 2013
Filed:
May 5, 2011
Appl. No.:
13/101978
Inventors:
Adilah Bahadoor - Cambridge MA, US
Alfredo C. Castro - Winchester MA, US
Lawrence K. Chan - Brookline MA, US
Gregg F. Keaney - Lexington MA, US
Marta Nevalainen - Weymouth MA, US
Vesa Nevalainen - Weymouth MA, US
Stephane Peluso - Brookline MA, US
Daniel A. Snyder - Somerville MA, US
Thomas T. Tibbitts - Westford MA, US
Alfredo C. Castro - Winchester MA, US
Lawrence K. Chan - Brookline MA, US
Gregg F. Keaney - Lexington MA, US
Marta Nevalainen - Weymouth MA, US
Vesa Nevalainen - Weymouth MA, US
Stephane Peluso - Brookline MA, US
Daniel A. Snyder - Somerville MA, US
Thomas T. Tibbitts - Westford MA, US
Assignee:
Infinity Pharmaceuticals, Inc. - Cambridge MA
International Classification:
A61K 31/41
C07D 249/00
C07D 249/00
US Classification:
514381, 548250
Abstract:
Provided herein are tetrazolone FASN inhibitors of the formula (I):Also provided herein are pharmaceutical compositions of the compounds provided herein as well as methods of their use for the treatment of various disorders such as hyperproliferative disorders, inflammatory disorders, obesity-related disorders and microbial infections.
Compounds And Methods For Inhibiting The Interaction Of Bcl Proteins With Binding Partners
View pageUS Patent:
8609706, Dec 17, 2013
Filed:
May 15, 2012
Appl. No.:
13/472136
Inventors:
Alfredo C. Castro - Winchester MA, US
Kristopher M. Depew - Acton MA, US
Michael J. Grogan - Winchester MA, US
Charles W. Johannes - Newbury MA, US
Edward B. Holson - Newton Highlands MA, US
Brian T. Hopkins - Newton MA, US
Gregg F. Keaney - Belmont MA, US
Nii O. Koney - New York NY, US
Tao Liu - Ashland MA, US
David A. Mann - Madison WI, US
Marta Nevalainen - Quincy MA, US
Stephane Peluso - Somerville MA, US
Lawrence Blas Perez - Hopkinton MA, US
Daniel A. Snyder - Somerville MA, US
Thomas T. Tibbitts - Westford MA, US
Kristopher M. Depew - Acton MA, US
Michael J. Grogan - Winchester MA, US
Charles W. Johannes - Newbury MA, US
Edward B. Holson - Newton Highlands MA, US
Brian T. Hopkins - Newton MA, US
Gregg F. Keaney - Belmont MA, US
Nii O. Koney - New York NY, US
Tao Liu - Ashland MA, US
David A. Mann - Madison WI, US
Marta Nevalainen - Quincy MA, US
Stephane Peluso - Somerville MA, US
Lawrence Blas Perez - Hopkinton MA, US
Daniel A. Snyder - Somerville MA, US
Thomas T. Tibbitts - Westford MA, US
Assignee:
Infinity Discovery, Inc. - Cambridge MA
International Classification:
A61K 31/42
C07D 261/02
C07D 261/02
US Classification:
514378, 548240
Abstract:
The invention relates to isoxazolidine containing compounds that bind to bcl proteins and inhibit Bcl function. The compounds may be used for treating and modulating disorders associated with hyperproliferation, such as cancer.
Enzymatic Transamination Of Cyclopamine Analogs
View pageUS Patent:
20120083607, Apr 5, 2012
Filed:
Jul 1, 2011
Appl. No.:
13/175053
Inventors:
Brian c. Austad - Tewksbury MA, US
Adilah Bahadoor - Stittsville, CA
Jitendra D. Belani - Newtonville MA, US
Charles W. Johannes - Singapore, SG
Gregg F. Keaney - Lexington MA, US
Priscilla L. White - Malden MA, US
Sheldon L. Wallerstein - Chesterfield MO, US
Adilah Bahadoor - Stittsville, CA
Jitendra D. Belani - Newtonville MA, US
Charles W. Johannes - Singapore, SG
Gregg F. Keaney - Lexington MA, US
Priscilla L. White - Malden MA, US
Sheldon L. Wallerstein - Chesterfield MO, US
Assignee:
Infinity Pharmaceuticals, Inc. - Cambridge MA
International Classification:
C07D 491/048
C12P 17/18
C12P 17/18
US Classification:
546 15, 435119
Abstract:
Provided are processes for the synthesis of amino analogues from ketone starting materials.
Triazoles As Inhibitors Of Fatty Acid Synthase
View pageUS Patent:
20130243727, Sep 19, 2013
Filed:
Apr 29, 2013
Appl. No.:
13/872999
Inventors:
Alfredo C. CASTRO - Winchester MA, US
Lawrence K. CHAN - Brookline MA, US
Gregg F. KEANEY - Lexington MA, US
Marta NEVALAINEN - Weymouth MA, US
Vesa NEVALAINEN - Weymouth MA, US
Stephane PELUSO - Brookline MA, US
Thomas T. TIBBITTS - Westford MA, US
Lawrence K. CHAN - Brookline MA, US
Gregg F. KEANEY - Lexington MA, US
Marta NEVALAINEN - Weymouth MA, US
Vesa NEVALAINEN - Weymouth MA, US
Stephane PELUSO - Brookline MA, US
Thomas T. TIBBITTS - Westford MA, US
Assignee:
INFINITY PHARMACEUTICALS, INC. - Cambridge MA
International Classification:
A61K 31/4192
A61K 31/454
C07D 401/12
C07D 401/06
C07D 249/04
A61K 31/4709
A61K 45/06
A61K 31/454
C07D 401/12
C07D 401/06
C07D 249/04
A61K 31/4709
A61K 45/06
US Classification:
424 855, 424 854, 424 857, 514314, 514359, 514326, 514 43
Abstract:
Provided herein are triazole FASN inhibitors of the formula (I):or a pharmaceutically acceptable form thereof; wherein the variables R, X, R, and Rare defined herein.Also provided herein are pharmaceutical compositions of the compounds provided herein as well as methods of their use for the treatment of various disorders such as hyperproliferative disorders, inflammatory disorders, obesity-related disorders and microbial infections.
Tetrazolones As Inhibitors Of Fatty Acid Synthase
View pageUS Patent:
20140079667, Mar 20, 2014
Filed:
Aug 23, 2013
Appl. No.:
13/975236
Inventors:
Alfredo C. Castro - Winchester MA, US
Lawrence K. Chan - Brookline MA, US
Gregg F. Keaney - Lexington MA, US
Marta Nevalainen - Weymouth MA, US
Vesa Nevalainen - Weymouth MA, US
Stephane Peluso - Brookline MA, US
Daniel A. Snyder - Somerville MA, US
Thomas T. Tibbitts - Westford MA, US
Lawrence K. Chan - Brookline MA, US
Gregg F. Keaney - Lexington MA, US
Marta Nevalainen - Weymouth MA, US
Vesa Nevalainen - Weymouth MA, US
Stephane Peluso - Brookline MA, US
Daniel A. Snyder - Somerville MA, US
Thomas T. Tibbitts - Westford MA, US
Assignee:
Infinity Pharmaceuticals, Inc. - Cambridge MA
International Classification:
C07D 257/04
A61K 31/7056
A61K 38/21
A61K 45/06
C07D 403/12
A61K 31/497
A61K 31/5377
C07D 405/12
A61K 31/4439
C07D 401/12
A61K 31/454
C07D 417/04
A61K 31/428
A61K 31/4184
C07D 403/04
C07D 401/14
A61K 31/4709
A61K 31/5415
A61K 31/55
C07D 295/185
C07D 295/205
A61K 31/41
A61K 31/7056
A61K 38/21
A61K 45/06
C07D 403/12
A61K 31/497
A61K 31/5377
C07D 405/12
A61K 31/4439
C07D 401/12
A61K 31/454
C07D 417/04
A61K 31/428
A61K 31/4184
C07D 403/04
C07D 401/14
A61K 31/4709
A61K 31/5415
A61K 31/55
C07D 295/185
C07D 295/205
A61K 31/41
US Classification:
424 855, 514381, 514 43, 424 857, 424 854, 51425405, 5142362, 514382, 514340, 514326, 514362, 514314, 5142258, 514217, 51421301
Abstract:
Provided herein are tetrazolone FASN inhibitors of the formula (I):or a pharmaceutically acceptable form thereof; wherein the variables R, Rand Rare defined herein.Also provided herein are pharmaceutical compositions of the compounds provided herein as well as methods of their use for the treatment of various disorders such as hyperproliferative disorders, inflammatory disorders, obesity-related disorders and microbial infections.
Compounds And Methods For Inhibiting The Interaction Of Bcl Proteins With Binding Partners
View pageUS Patent:
7928244, Apr 19, 2011
Filed:
Aug 21, 2007
Appl. No.:
11/842581
Inventors:
Alfredo C. Castro - Winchester MA, US
Kristopher M. Depew - Acton MA, US
Michael J. Grogan - Winchester MA, US
Charles W. Johannes - Newbury MA, US
Edward B. Holson - Newton Highlands MA, US
Brian T. Hopkins - Newton MA, US
Gregg F. Keaney - Belmont MA, US
Nii O. Koney - Brighton MA, US
Tao Liu - Ashland MA, US
David A. Mann - Swampscott MA, US
Marta Nevalainen - Quincy MA, US
Stephane Peluso - Somerville MA, US
Lawrence B. Perez - Hopkinton MA, US
Daniel A. Snyder - Somerville MA, US
Thomas T. Tibbitts - Westford MA, US
Kristopher M. Depew - Acton MA, US
Michael J. Grogan - Winchester MA, US
Charles W. Johannes - Newbury MA, US
Edward B. Holson - Newton Highlands MA, US
Brian T. Hopkins - Newton MA, US
Gregg F. Keaney - Belmont MA, US
Nii O. Koney - Brighton MA, US
Tao Liu - Ashland MA, US
David A. Mann - Swampscott MA, US
Marta Nevalainen - Quincy MA, US
Stephane Peluso - Somerville MA, US
Lawrence B. Perez - Hopkinton MA, US
Daniel A. Snyder - Somerville MA, US
Thomas T. Tibbitts - Westford MA, US
Assignee:
Infinity Discovery, Inc. - Cambridge MA
International Classification:
C07D 261/02
A61K 31/42
A61K 31/42
US Classification:
548240, 514378
Abstract:
The invention relates to isoxazolidine containing compounds that bind to bcl proteins and inhibit Bcl function. The compounds may be used for treating and modulating disorders associated with hyperproliferation, such as cancer.