Gilles Y Genain

59227036, Jul 13, 1999

Sep 24, 1993

8/126293

Chia-Nien Yu - Norwich NY
Gilles Yves Genain - Wyoming OH
Rachel Boujo - Paris, FR

The Procter & Gamble Company - Cincinnati OH

A61K 3156
C07J 4100

514182

Urethane-containing amino steroids having the general chemical formula: ##STR1## wherein a, b, R. sub. 1, R. sub. 2, R. sub. 3, R. sub. 4, R. sub. 14 and Z are as defined in the specification. Also disclosed are pharmaceutical composition and the use of the compounds/composition in the treatment of congestive heart failure.

57212171, Feb 24, 1998

Jun 2, 1995

8/460348

Song Liu - Norwich NY
David Edward Portlock - Norwich NY
Gilles Yves Genain - Wyoming OH
Jean-Jacques Koenig - Maisons Lafitte, FR
Jacques de Rostolan - Gif Sur Yvette, FR

The Procter & Gamble Company - Cincinnati OH

A61K 31705
C07H 1524

514 26

Disclosed are 14-aminosteroid compounds, including pharmaceutically acceptable acid salts and esters thereof, useful in treating individuals afflicted with congestive heart failure, which compounds have the general formula: ##STR1## wherein R. sub. 3 is a deoxy or oxygen-substituted monosaccharide sugar residue and R. sub. 1, R. sub. 2 and R. sub. 4 are various other substituents as defined herein.

57836779, Jul 21, 1998

Jun 5, 1995

8/463393

Song Liu - Norwich NY
David Edward Portlock - Norwich NY
Gilles Yves Genain - Wyoming OH
Jean-Jacques Koenig - Maisons Lafitte, FR
Jacques de Rostolan - Gif Sur Yvette, FR
Randy Stuart Muth - Poolville NY

Procter & Gamble Pharmaceuticals, Inc.

C07H 1308
C07H 100

536 41

The present invention relates to a method for making a compound of the structure: ##STR1## comprising the steps: (a) adding 6-deoxy-. alpha. -L-mannopyranosyl bromide, 2,3,4-tri-O-benzoate; DMSO; a base, selected from the group including tertiary amines, amidines, bicarbonates, carbonates, heteroaryl amine, and a solvent, hydrocarbons, esters, and ethers, in a slurry heated to 50. degree. -150. degree. C. ; (b) stirring the reaction mixture at 50. degree. -150. degree. C. for 5 minutes to 30 minutes, (c) pouring the reaction mixture over ice water; and (d) extracting the product with a solvent selected from the group consisting of chlorinated solvents, aromatic hydrocarbons, esters, ethers, and evaporating said layer to give a solid.