Resumes
Resumes
Gert Kiss Phones & Addresses
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Santa Clara, CA
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San Jose, CA
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Palo Alto, CA
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Los Angeles, CA
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Asheville, NC
Publications
Us Patents
Rapamycin Analogs As Mtor Inhibitors
View pageUS Patent:
20230093861, Mar 30, 2023
Filed:
Mar 11, 2022
Appl. No.:
17/693225
Inventors:
- Redwood City CA, US
Arun P. THOTTUMKARA - Redwood City CA, US
G. Leslie BURNETT - Redwood City CA, US
Micah James Evans GLIEDT - Redwood City CA, US
Gert KISS - Redwood City CA, US
Walter WON - Redwood City CA, US
Julie Chu-Li LEE - Redwood City CA, US
Adrian Liam GILL - Redwood City CA, US
Christopher SEMKO - Redwood City CA, US
Jennifer PITZEN - Redwood City CA, US
Gang WANG - Redwood City CA, US
Nidhi TIBREWAL - Redwood City CA, US
Arun P. THOTTUMKARA - Redwood City CA, US
G. Leslie BURNETT - Redwood City CA, US
Micah James Evans GLIEDT - Redwood City CA, US
Gert KISS - Redwood City CA, US
Walter WON - Redwood City CA, US
Julie Chu-Li LEE - Redwood City CA, US
Adrian Liam GILL - Redwood City CA, US
Christopher SEMKO - Redwood City CA, US
Jennifer PITZEN - Redwood City CA, US
Gang WANG - Redwood City CA, US
Nidhi TIBREWAL - Redwood City CA, US
International Classification:
C07D 519/00
Abstract:
The present disclosure relates to mTOR inhibitors. Specifically, the embodiments are directed to compounds and compositions inhibiting mTOR, methods of treating diseases mediated by mTOR, and methods of synthesizing these compounds.
Covalent Ras Inhibitors And Uses Thereof
View pageUS Patent:
20230100838, Mar 30, 2023
Filed:
May 26, 2022
Appl. No.:
17/825875
Inventors:
- Redwood City CA, US
James AGGEN - Burlingame CA, US
G. Leslie BURNETT - Redwood City CA, US
Adrian L. GILL - Atherton CA, US
Christopher SEMKO - Fremont CA, US
Anne V. EDWARDS - San Mateo CA, US
Micah James GLIEDT - Fremont CA, US
Gert KISS - Palo Alto CA, US
Ashutosh JOGALEKAR - Menlo Park CA, US
John E. KNOX - Emerald Hills CA, US
Andreas BUCKL - San Francisco CA, US
Elena S. KOLTUN - Foster City CA, US
James AGGEN - Burlingame CA, US
G. Leslie BURNETT - Redwood City CA, US
Adrian L. GILL - Atherton CA, US
Christopher SEMKO - Fremont CA, US
Anne V. EDWARDS - San Mateo CA, US
Micah James GLIEDT - Fremont CA, US
Gert KISS - Palo Alto CA, US
Ashutosh JOGALEKAR - Menlo Park CA, US
John E. KNOX - Emerald Hills CA, US
Andreas BUCKL - San Francisco CA, US
Elena S. KOLTUN - Foster City CA, US
International Classification:
A61K 47/64
A61K 45/06
C07D 471/04
C07D 401/12
C07D 401/04
C07D 239/94
C07D 413/14
C07D 498/16
A61K 45/06
C07D 471/04
C07D 401/12
C07D 401/04
C07D 239/94
C07D 413/14
C07D 498/16
Abstract:
The disclosure features compounds, or pharmaceutically acceptable salts thereof, alone and in combination with other therapeutic agents, pharmaceutical compositions, and protein conjugates thereof, capable of modulating biological processes including Ras, and their uses in the treatment of cancers.
C40-, C28-, And C-32-Linked Rapamycin Analogs As Mtor Inhibitors
View pageUS Patent:
20230055672, Feb 23, 2023
Filed:
Apr 29, 2022
Appl. No.:
17/733755
Inventors:
- Redwood City CA, US
Micah James Evans Gliedt - Redwood City CA, US
G. Leslie Burnett - Redwood City CA, US
James Bradley Aggen - Redwood City CA, US
Gert Kiss - Redwood City CA, US
James Joseph Cregg - Redwood City CA, US
Christopher Michael Semko - Redwood City CA, US
Walter Won - Redwood City CA, US
Gang Wang - Redwood City CA, US
Julie Chu-Li Lee - Redwood City CA, US
Arun P. Thottumkara - Redwood City CA, US
Adrian Liam Gill - Redwood City CA, US
Kevin T. Mellem - Redwood City CA, US
Micah James Evans Gliedt - Redwood City CA, US
G. Leslie Burnett - Redwood City CA, US
James Bradley Aggen - Redwood City CA, US
Gert Kiss - Redwood City CA, US
James Joseph Cregg - Redwood City CA, US
Christopher Michael Semko - Redwood City CA, US
Walter Won - Redwood City CA, US
Gang Wang - Redwood City CA, US
Julie Chu-Li Lee - Redwood City CA, US
Arun P. Thottumkara - Redwood City CA, US
Adrian Liam Gill - Redwood City CA, US
Kevin T. Mellem - Redwood City CA, US
International Classification:
A61K 47/54
A61K 31/436
A61K 31/519
A61K 31/553
A61K 31/436
A61K 31/519
A61K 31/553
Abstract:
The present disclosure relates to mTOR inhibitors. Specifically, the embodiments are directed to compounds and compositions inhibiting mTOR, methods of treating diseases mediated by mTOR, and methods of synthesizing these compounds.
C40-, C28-, And C-32-Linked Rapamycin Analogs As Mtor Inhibitors
View pageUS Patent:
20210338824, Nov 4, 2021
Filed:
Oct 28, 2020
Appl. No.:
17/083172
Inventors:
- Redwood City CA, US
Micah James Evans Gliedt - Redwood City CA, US
G. Leslie Burnett - Redwood City CA, US
James Bradley Aggen - Redwood City CA, US
Gert Kiss - Redwood City CA, US
James Joseph Cregg - Redwood City CA, US
Christopher Michael Semko - Redwood City CA, US
Walter Won - Redwood City CA, US
Gang Wang - Redwood City CA, US
Julie Chu-Li Lee - Redwood City CA, US
Arun P. Thottumkara - Redwood City CA, US
Adrian Liam Gill - Redwood City CA, US
Kevin T. Mellem - Redwood City CA, US
Micah James Evans Gliedt - Redwood City CA, US
G. Leslie Burnett - Redwood City CA, US
James Bradley Aggen - Redwood City CA, US
Gert Kiss - Redwood City CA, US
James Joseph Cregg - Redwood City CA, US
Christopher Michael Semko - Redwood City CA, US
Walter Won - Redwood City CA, US
Gang Wang - Redwood City CA, US
Julie Chu-Li Lee - Redwood City CA, US
Arun P. Thottumkara - Redwood City CA, US
Adrian Liam Gill - Redwood City CA, US
Kevin T. Mellem - Redwood City CA, US
International Classification:
A61K 47/54
A61K 31/436
A61K 31/519
A61K 31/553
A61K 31/436
A61K 31/519
A61K 31/553
Abstract:
The present disclosure relates to mTOR inhibitors. Specifically, the embodiments are directed to compounds and compositions inhibiting mTOR, methods of treating diseases mediated by mTOR, and methods of synthesizing these compounds.
2,5-Disubstituted 3-Methyl Pyrazines And 2,5,6-Trisubstituted 3-Methyl Pyrazines As Allosteric Shp2 Inhibitors
View pageUS Patent:
20210101870, Apr 8, 2021
Filed:
Jun 18, 2020
Appl. No.:
16/905884
Inventors:
- Redwood City CA, US
Kevin MELLEM - Redwood City CA, US
Adrian GILL - Redwood City CA, US
Gert KISS - Redwood City CA, US
Christopher SEMKO - Redwood City CA, US
Naing AAY - Redwood City CA, US
Andreas BUCKL - Redwood City CA, US
Ashutosh JOGALEKAR - Redwood City CA, US
Walter WON - Redwood City CA, US
Kevin MELLEM - Redwood City CA, US
Adrian GILL - Redwood City CA, US
Gert KISS - Redwood City CA, US
Christopher SEMKO - Redwood City CA, US
Naing AAY - Redwood City CA, US
Andreas BUCKL - Redwood City CA, US
Ashutosh JOGALEKAR - Redwood City CA, US
Walter WON - Redwood City CA, US
International Classification:
C07D 241/20
C07D 403/12
C07D 403/04
C07D 241/18
A61P 35/02
A61P 35/04
C07D 401/04
C07D 477/26
C07D 487/04
C07D 403/12
C07D 403/04
C07D 241/18
A61P 35/02
A61P 35/04
C07D 401/04
C07D 477/26
C07D 487/04
Abstract:
The present disclosure is directed to inhibitors of SHP2, such as pyrazine compounds, and their use in the treatment of disease associated with SHP2 modulation, such as Noonan Syndrome, Leopard Syndrome, juvenile myelomonocytic leukemias, neuroblastoma, melanoma, acute myeloid leukemia and cancers of the breast, lung and colon. Also disclosed are pharmaceutical compositions comprising the same.
Rapamycin Analogs As Mtor Inhibitors
View pageUS Patent:
20210094975, Apr 1, 2021
Filed:
Oct 30, 2019
Appl. No.:
16/669319
Inventors:
- Redwood City CA, US
Arun P. THOTTUMKARA - Redwood City CA, US
G. Leslie BURNETT - Redwood City CA, US
Micah James Evans GLIEDT - Redwood City CA, US
Gert KISS - Redwood City CA, US
Walter WON - Redwood City CA, US
Julie Chu-Li LEE - Redwood City CA, US
Adrian Liam GILL - Redwood City CA, US
Christopher SEMKO - Redwood City CA, US
Jennifer PITZEN - Redwood City CA, US
Gang WANG - Redwood City CA, US
Nidhi TIBREWAL - Redwood City CA, US
Arun P. THOTTUMKARA - Redwood City CA, US
G. Leslie BURNETT - Redwood City CA, US
Micah James Evans GLIEDT - Redwood City CA, US
Gert KISS - Redwood City CA, US
Walter WON - Redwood City CA, US
Julie Chu-Li LEE - Redwood City CA, US
Adrian Liam GILL - Redwood City CA, US
Christopher SEMKO - Redwood City CA, US
Jennifer PITZEN - Redwood City CA, US
Gang WANG - Redwood City CA, US
Nidhi TIBREWAL - Redwood City CA, US
International Classification:
C07D 519/00
Abstract:
The present disclosure relates to mTOR inhibitors. Specifically, the embodiments are directed to compounds and compositions inhibiting mTOR, methods of treating diseases mediated by mTOR, and methods of synthesizing these compounds.
Bicyclic Compounds As Allosteric Shp2 Inhibitors
View pageUS Patent:
20200017511, Jan 16, 2020
Filed:
Jul 22, 2019
Appl. No.:
16/518798
Inventors:
- Redwood City CA, US
Jennifer PITZEN - Redwood City CA, US
Gang WANG - Redwood City CA, US
Walter S. WON - Redwood City CA, US
Jie Jack LI - Redwood City CA, US
Elena S. KOLTUN - Redwood City CA, US
Naing AAY - Redwood City CA, US
Andreas BUCKL - Redwood City CA, US
Kevin MELLEM - Redwood City CA, US
Christopher SEMKO - Redwood City CA, US
Ash JOGALEKAR - Redwood City CA, US
Gert KISS - Redwood City CA, US
Adrian GILL - Redwood City CA, US
Jennifer PITZEN - Redwood City CA, US
Gang WANG - Redwood City CA, US
Walter S. WON - Redwood City CA, US
Jie Jack LI - Redwood City CA, US
Elena S. KOLTUN - Redwood City CA, US
Naing AAY - Redwood City CA, US
Andreas BUCKL - Redwood City CA, US
Kevin MELLEM - Redwood City CA, US
Christopher SEMKO - Redwood City CA, US
Ash JOGALEKAR - Redwood City CA, US
Gert KISS - Redwood City CA, US
Adrian GILL - Redwood City CA, US
International Classification:
C07D 487/04
C07D 519/00
C07D 513/04
C07D 471/04
C07D 519/00
C07D 513/04
C07D 471/04
Abstract:
The present disclosure is directed to inhibitors of SHP2 and their use in the treatment of disease. Also disclosed are pharmaceutical compositions comprising the same.
Pyridine Compounds As Allosteric Shp2 Inhibitors
View pageUS Patent:
20200017517, Jan 16, 2020
Filed:
Jul 22, 2019
Appl. No.:
16/518796
Inventors:
- Redwood City CA, US
Naing AAY - Redwood City CA, US
Kevin MELLEM - Redwood City CA, US
Andreas BUCKL - Redwood City CA, US
Elena S. KOLTUN - Redwood City CA, US
Christopher SEMKO - Redwood City CA, US
Gert KISS - Redwood City CA, US
Naing AAY - Redwood City CA, US
Kevin MELLEM - Redwood City CA, US
Andreas BUCKL - Redwood City CA, US
Elena S. KOLTUN - Redwood City CA, US
Christopher SEMKO - Redwood City CA, US
Gert KISS - Redwood City CA, US
International Classification:
C07D 491/107
C07D 401/04
C07D 401/14
C07D 401/04
C07D 401/14
Abstract:
The present disclosure is directed to inhibitors of SHP2 and their use in the treatment of disease. Also disclosed are pharmaceutical compositions comprising the same.