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Garth A Powis

from La Jolla, CA
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Also known as:
Garth Powers, G Powers, G Powis, L Powis
Phone and address:
6019 Folsom Dr, La Jolla, CA 92037
Related to:
Aaron M Brown, 60Bethany Kirkpatrick, 67Margareta M Berggren, 78Pauline E Morris, 78D Lynn Kirkpatrick, 67Zoe V Powis, 49Lynn Powis
Connected to:
Lynn M Powis, 60Omari S Powis, 37Michelle Powitchko, 56Sarah Powitzky, 34Andrew R Powl, 37Mark S Powlen, 38Jill N Powles, 41Joanne M Powles, 88Linda L Powles, 83Marie A Powles, 104

Garth Powis Phones & Addresses

  • 6019 Folsom Dr, La Jolla, CA 92037
  • 326 Cowan Dr, Houston, TX 77007 (713) 864-7512
  • 6019 Folsom Dr, La Jolla, CA 92037 (713) 864-7512

Work

Position: Administration/Managerial

Education

Degree: Associate degree or higher

Business Records

Name / Title
Company / Classification
Phones & Addresses
Garth Powis
Director
Phusis Therapeutics, Inc
Mfg Medicinal/Botanical Products
7000 Fannin St, Houston, TX 77030
Garth Powis
Director
PHUSIS THERAPEUTICS, INC
3210 Merryfield Row, San Diego, CA 92121
7000 Fannin SUITE 2115, Houston, TX 77070

Publications

Isbn (Books And Publications)

The Toxicity of Anticancer Drugs

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Author

Garth Powis

ISBN #

0071053050

The Toxicity of Anticancer Drugs

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Author

Garth Powis

ISBN #

0080403026

Anticancer Drugs: Antimetabolite Metabolism and Natural Anticancer Agents

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Author

Garth Powis

ISBN #

0080423345

Anticancer Drugs: Reactive Metabolism and Drug Interactions

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Author

Garth Powis

ISBN #

0080423353

Pharmacokinetics of Anticancer Agents in Humans

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Author

Garth Powis

ISBN #

0444805184

Metabolism and Action of Anti-Cancer Drugs

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Author

Garth Powis

ISBN #

0850663695

Us Patents

Wortmannin Analogs And Methods Of Using Same

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US Patent:
7335679, Feb 26, 2008
Filed:
Apr 7, 2006
Appl. No.:
11/279000
Inventors:
Garth Powis - Houston TX, US
Peter Wipf - Pittsburgh PA, US
Assignee:
Arizona Board of Regents on behalf of the University of Arizona - Tucson AZ
University of Pittsburgh - Pittsburgh PA
International Classification:
A61K 31/4025
C07D 405/06
US Classification:
514422, 548525
Abstract:
Novel Wortmannin analogs and their use in inhibiting inhibiting PI-3-kinase activity in mammals as well as tumor formation in a subject are described herein.

Metabolites Of Wortmannin Analogs And Methods Of Using The Same

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US Patent:
7723375, May 25, 2010
Filed:
Dec 29, 2006
Appl. No.:
11/618036
Inventors:
Garth Powis - Houston TX, US
Assignee:
Arizona Board of Regents, acting on behalf of The University of Arizona - Tucson AZ
International Classification:
A61K 31/352
A61K 31/407
C07D 311/78
C07D 405/02
US Classification:
514422, 514453, 548525, 549383
Abstract:
Novel metabolites of wortmannin and wortmannin analogs and their use in inhibiting PI-3 kinase activity in mammals and the treatment and prevention of cancer or tumor formation in a subject are described herein.

Wortmannin Analogs And Methods Of Using Same

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US Patent:
7776908, Aug 17, 2010
Filed:
Sep 20, 2007
Appl. No.:
11/858508
Inventors:
Garth Powis - Houston TX, US
Peter Wipf - Pittsburgh PA, US
Assignee:
Arizona Board of Regents - Tucson AZ
The University of Pittsburgh - Pittsburgh PA
International Classification:
A61K 31/352
A61K 31/407
US Classification:
514422, 514453
Abstract:
Novel Wortmannin analogs and their use in inhibiting inhibiting PI-3-kinase activity in mammals as well, as tumor formation in a subject are described herein.

Wortmannin Analogs And Methods Of Using Same In Combination With Chemotherapeutic Agents

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US Patent:
7858657, Dec 28, 2010
Filed:
Sep 23, 2008
Appl. No.:
12/235730
Inventors:
Lynn D. Kirkpatrick - Houston TX, US
Garth Powis - Houston TX, US
Peter Wipf - Pittsburgh PA, US
Assignee:
Proix Pharmaceutical Corp. - Seattle WA
Arizona Board of Regents, Acting on Behalf of The University of Arizona - Tucson AZ
University of Pittsburgh - Of the Commonwealth System of Higher Education - Pittsburgh PA
International Classification:
A61K 31/352
A61K 31/4025
C07D 311/78
C07D 405/14
US Classification:
514422, 514453, 548525, 549276
Abstract:
Novel wortmannin analogs and their use in inhibiting PI-3-kinase activity in mammals and the treatment or prevention of cancer and tumor formation in a subject are described herein. Preferably, the wortmannin analogs may be administered with other chemotherapeutic agents in the treatment of cancer.

Palmarumycin Based Inhibitors Of Thioredoxin And Methods Of Using Same

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US Patent:
8124651, Feb 28, 2012
Filed:
Sep 15, 2006
Appl. No.:
12/066426
Inventors:
Garth Powis - Houston TX, US
Peter Wipf - Pittsburg PA, US
Assignee:
The University of Pittsburgh Office of Technology Transfer - Pittsburgh PA
Arizona Board of Regents - Tucson AZ
International Classification:
A61K 31/357
C07D 319/08
US Classification:
514452, 549358, 549359
Abstract:
Embodiments of the present invention relate to inhibitors of thioredoxin. Certain embodiments relate to palmarumycin based compounds and methods of using the same. Such compounds may be useful in inhibiting the overexpression of thioredoxin, inhibiting tumor growth and treating cancer.

Small Molecule Inhibitors Of The Pleckstrin Homology Domain And Methods For Using Same

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US Patent:
8420678, Apr 16, 2013
Filed:
Apr 14, 2009
Appl. No.:
12/937898
Inventors:
Daruka Mahadevan - Tucson AZ, US
Emmanuelle J. Meuillet - Oro Valley AZ, US
Garth Powis - Houston TX, US
Shuxing Zhang - Pearland TX, US
Assignee:
Board of Regents, The University of Texas System - Austin TX
Arizona Board of Regents on Behalf of the University of Arizona - Tucson AZ
International Classification:
A61K 31/433
C07D 285/135
US Classification:
514363, 548138
Abstract:
Pleckstrin homology domain binding compounds, pharmaceutical compositions including such compounds, and methods for their use are described herein.

Metabolites Of Wortmannin Analogs And Methods Of Using The Same

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US Patent:
8586626, Nov 19, 2013
Filed:
Jun 10, 2011
Appl. No.:
13/158260
Inventors:
Garth Powis - Houston TX, US
Assignee:
Arizona Board of Regents, Acting on Behalf of the University of Arizona - Tucson AZ
International Classification:
A61K 31/352
C07D 311/78
US Classification:
514453, 549383
Abstract:
Novel metabolites of wortmannin and wortmannin analogs and their use in inhibiting PI-3 kinase activity in mammals and the treatment and prevention of cancer or tumor formation in a subject are described herein.

Method Of Preselection Patients For Anti-Vegf, Anti-Hif-1 Or Anti-Thioredoxin Therapy

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US Patent:
20060104902, May 18, 2006
Filed:
Aug 17, 2005
Appl. No.:
11/206526
Inventors:
Garth Powis - Houston TX, US
Lynn Kirkpatrick - Houston TX, US
Robert Gillies - Tucson AZ, US
Benedicte Jordan - Brussels, BE
International Classification:
A61K 49/00
A61K 39/395
A61K 31/4166
US Classification:
424009100, 424145100, 514398000
Abstract:
The present invention generally relates to methods of preselecting patients for treatment with an anti-VEGF therapy, anti-HIF-1 therapy or anti-thioredoxin therapy. Aspects of the invention combine methods of dynamic contrast enhanced-MRI and diffusion weighted-MRI for the detection of tumor histology. The methodology disclosed herein detects tissue blood volume, tumor vascularity, and abnormal capillary permeability, thereby determining tumor vascularity to determine whether a patient should be administered such therapy.
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Garth A Powis from La Jolla, CA Get Report