Ganapathi R Revankar

49506471, Aug 21, 1990

Oct 4, 1988

7/253050

Roland K. Robins - Irvine CA
Brahma S. Sharma - Irvine CA
Ganapathi R. Revankar - Irvine CA

Nucleic Acid Research Institute - Costa Mesa CA

A61K 31395
A61K 3170
C07H 19123

514 45

##STR1## 6-Amino-1-(2-deoxy-. alpha. D-erythro-pentofuranosyl)imidazo [4,5-C]pyridin-4-one (also know as. alpha. -2'-deoxy-3-deazaguanosine) is non mitogenic to human peripheral blood lymphocytes; however, it displays a potent immunoenhancing activity on human T cells. This compound causes a marked increase in both phytohemagglutinin and Concanavalin A induced proliferation of T cells. When added during allogeneic mixed lymphocyte response, it also potentiates the proliferation of alloreative T cells. The compound shows no potentiating effect on B lymphocytes activated either with Staphylococcus aureus cowan or Pokeweed mitogen, suggesting that it is mainly a T cell function immunopotentiator. The compound overcomes induced immunosuppression and is able to restore depressed proliferative responses of T cells. Further it potentiates the generation of antigen-specific primary cytotoxic T lymphocytes.

47601370, Jul 26, 1988

Jan 15, 1987

7/008048

Roland K. Robins - Provo UT
Ganapathi R. Revankar - Orem UT

Brigham Young University - Provo UT

C07H 19173

536 26

A method that is direct and stereospecific is provided for the production of 2'-deoxyadenosine derivatives and related analogs. The method comprises glycosylation of the sodium salt of 2,6-dichloropurine or 6-chloropurine and ammonolysis of the glycosylate to obtain the corresponding 2-chloro-2'-deoxyadenosine or 2'-deoxyadenosine.

40937143, Jun 6, 1978

Mar 15, 1974

5/451639

Richard L. Tolman - Berkley Heights NJ
Robert W. Sidwell - Irvine CA
Ganapathi R. Revankar - Santa Ana CA

ICN Pharmaceuticals, Inc. - Irvine CA

A61K 3152
C07H 1920
A61K 3170

424180

9-. beta. -D-Arabinofuranosyl nucleotides of the following structure are disclosed: ##STR1## wherein AP is a 3' or 5' phosphorylated arabinofuranoside or the corresponding 3', 5' cyclic phosphate joined by a glycoside linkage to N. sup. 9 of the aglycon component of said nucleotide, and Z is H, C. sub. 1 -C. sub. 6 alkyl, C. sub. 7 -C. sub. 10 aralkoxy, or hydroxy. Compounds prepared according to the invention exhibit antiviral activity in vitro, while others are precursors useful in the synthesis of bioactive compounds.

54460450, Aug 29, 1995

Dec 20, 1993

8/170559

Ganapathi R. Revankar - The Woodlands TX
Arthur F. Lewis - The Woodlands TX
Birendra K. Bhattacharya - The Woodlands TX
Rodrigo V. Devivar - Spring TX
Robert F. Rando - The Woodlands TX
Susan M. Fennewald - The Woodlands TX

A61K 31505

514258

A series of guanine analogs having the basic structures of ##STR1## and physiological salts thereof. Also disclosed are a variety of the use of the compounds as a composition with a physiological carrier or in combination therapy with acyclovir, HBG and ganciclovir in the treatment of viral disease.

48618730, Aug 29, 1989

Dec 21, 1987

7/136407

Roland K. Robins - Irvine CA
Ganapathi R. Revankar - Irvine CA
Yu-an Chang - Costa Mesa CA

Nucleic Acid Research Institute - Costa Mesa CA

C07H 1920
C07H 1900

536 27

The compound 8-Chloroadenosine 3',5'-cyclic phosphate is used to treat malignant tumors in warm blooded animals. Two novel single step syntheses of 8-chloroadenosine 3',5'-cyclic phosphate and other related adenine and adenosine compounds from corresponding adenosine 3', 5'-cyclic phosphate and other respective related adenosine compounds are disclosed.

40936244, Jun 6, 1978

Jan 31, 1977

5/763913

Ganapathi R. Revankar - Santa Ana CA
Roland K. Robins - Santa Ana CA

ICN Pharmaceuticals, Inc. - Irvine CA

C07D28508

260302D

Compounds of the structure ##STR1## wherein Y is O, NH or NAc; X is H,. beta. -D-ribofuranosyl or 2,3,5-tri-O-Ac-. beta. -D-ribofuranosyl and Ac is acetyl; are useful as antimicrobal agent.

51752662, Dec 29, 1992

Apr 19, 1991

7/687807

Rajender S. Varma - The Woodlands TX
Michael E. Hogan - The Woodlands TX
Ganapathi R. Revankar - The Woodlands TX

Triplex Pharmaceutical Corporation - Houston TX
Baylor College of Medicine - Houston TX

C07H 1900
C07H 2100
C07D30702

536 22

Nucleoside derivatives which contain a nucleo-base, a sugar and an amino acid backbone of the structure: ##STR1## where R' refers to the various amino acid side chains or their blocked equivalent and R refers to a nucleo-base or its blocked equivalent. The synthesis of these nucleoside derivatives proceeds by a series of steps including oxidation of the 3'-azido nucleoside derivative, coupling to a benzylated ester of an amino acid to yield the amide and hydrogenation. The adenine, guanine, cytosine and thymine nucleosides with an amino acid at the 5' terminus are synthesized. From such monomers oligonucleotides can be synthesized which possess an amino acid backbone, using either solid state phase chemistry or liquid phase chemistry.

59943211, Nov 30, 1999

Jun 10, 1997

8/872251

Arthur F. Lewis - The Woodlands TX
Ganapathi R. Revankar - The Woodlands TX

Aronex Pharmaceuticals, Inc. - The Woodlands TX

A61K 3152
A61K 3170

514 45

A series of guanine analogs and physiological salts thereof, which are useful as virus inhibitors and as antiviral agents in the treatment of viral disease, having the basic structures of: ##STR1## wherein B is H, CH. sub. 3 or NH. sub. 2 ; C is NH. sub. 2 or SCH. sub. 3 ; D is N or CH; E is O, S or Se; and G is selected from a group consisting of alkanes, alkenes, ethers, esters, hydrocarbons, amines and heterocyclic compounds, is herein disclosed. In I and III, A is O, S or Se while in II, A is NH. sub. 2, OH, NHOH, OCH. sub. 3 or SCH. sub. 3. In I and II, F is 0, S or Se, while in III, F is F is 0, S, Se or NH. These compounds may be formulated with a physiological carrier, and used either alone or in combination with, for example, acyclovir or ganciclovir or another therapeutic agent, for the treatment of conditions resulting from viral infections.