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Frederick W Quelle

from Coralville, IA
Age ~61
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Also known as:
Frederick E Quelle, Fred W Quelle, Federick Quelle, Fredrick Quelle
Phone and address:
355 Auburn Hills Dr, Iowa City, IA 52241
(319) 338-7353
Related to:
Caitlin E Quelle, 24Dawn E Quelle, 59Claudia J Quelle, 85Fred W Quelle, 90Liana Pai, 58Geoffrey W Quelle, 59Liana Quelle, 58Duncan E Beaton, 98
Connected to:
Ben W Quelle, 53Dale E Quelle, 72David O Quelle, 69Donna L Quelle, 66Manuel Quelle, 43Heather L Quellet, 42Jessica Quellhorst, 34John D Quellhorst, 69Sylvia K Quellmalz, 63Michael F Quemado, 90

Frederick Quelle Phones & Addresses

  • 355 Auburn Hills Dr, Coralville, IA 52241 (319) 338-7353
  • Cordova, TN
  • State College, PA
  • Cohasset, MA
  • Middlebury, VT

Publications

Us Patents

Jak Kinases And Regulation Of Cytokine Signal Transduction

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US Patent:
6969760, Nov 29, 2005
Filed:
Sep 17, 1999
Appl. No.:
09/397967
Inventors:
James Ihle - Memphis TN, US
Bruce A. Witthuhn - Memphis TN, US
Frederick W. Quelle - Memphis TN, US
Ollie Silvennoinen - Helsinki, FI
Assignee:
St. Jude Children's Research Hospital - Memphis TN
International Classification:
C07H021/04
C12N015/00
C12N015/63
C12N005/00
US Classification:
536 231, 4353201, 435455, 435325
Abstract:
The invention relates generally to the Jak family of kinases. This includes the DNA and amino acid sequences for Jak 3 kinases. Additionally, the invention concerns expression vectors comprising DNA sequences encoding a Jak 3 kinase and host cell containing such expression vectors.

Jak Kinases And Regulation Of Cytokine Signal Transduction

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US Patent:
62106546, Apr 3, 2001
Filed:
Oct 8, 1997
Appl. No.:
8/946994
Inventors:
James Ihle - Memphis TN
Bruce A. Witthuhn - Memphis TN
Frederick W. Quelle - Memphis TN
Ollie Silvennoinen - Helsinki, FI
Assignee:
St. Jude Children's Hospital - Memphis TN
International Classification:
A61K 4900
US Classification:
424 92
Abstract:
Provided are methods for regulating the cellular response to cytokines by inhibiting or enhancing of at least one Jak kinase activity which mediates the response; assays for identifying inhibitors of Jak kinase activity or cytokine-induced Jak kinase activation useful in the methods of the invention are also provided; antibodies raised against peptide fragments of at least one epitope specific for a Jak kinase without interfering with kinase activity; polypeptides for Jak kinases; and nucleic acid encoding therefor.

Jak Kinases And Regulation Of Cytokine Signal Transduction

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US Patent:
57285365, Mar 17, 1998
Filed:
Jul 29, 1994
Appl. No.:
8/097997
Inventors:
James N. Ihle - Memphis TN
Bruce A. Witthuhn - Memphis TN
Frederick W. Quelle - Cordova TN
Ollie Silvennoinen - New York NY
Assignee:
St. Jude Children's Research Hospital - Memphis TN
International Classification:
G01N 33567
G01N 33573
G01N 3353
G01N 33543
US Classification:
435 721
Abstract:
The present invention is based on the discovery that a critical step in the cellular response to several cytokines is the activation (i. e. tyrosine phosphorylation) of a member of the Jak kinase family. In particular, several cytokines whose activity is mediated by the activation of Jak2 kinase are identified. The present invention provides novel methods for regulating the cellular response to these cytokines by inhibiting or enhancing the Jak kinase activity which mediates the response. Assays for identifying inhibitors of Jak kinase activity or cytokine-induced Jak kinase activation useful in the methods of the invention are also provided. Antibodies raised against peptide fragments of Jak1, Jak2, and Tyk2 kinase capable of specifically binding to these Jak kinases without interfering with kinase activity are also provided. In addition, the complete DNA coding sequence and amino acid structure of Jak2 kinase is provided by the invention.
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Frederick W Quelle from Coralville, IA, age ~61 Get Report