Frederick D Cazer

6410520, Jun 25, 2002

Jan 29, 2001

09/771825

Frederick Dana Cazer - Earlville NY
Gregory Eugene Parry - Lawrenceville NJ
Dennis Michael Billings - Norwich NY
Nancy Lee Redman-Furey - Smyrna NY

The Procter Gamble Company - Cincinnati OH

A61K 31663

514 89, 546 22

The present invention discloses 3-pyridyl-1-hydroxyethylidene-1,1-bisphosphonic acid sodium hemipentahydrate and monohydrate, methods of preparing the hemipentahydrate or monohydrate through control of the nucleation temperature and rate of crystallization and pharmaceutical compositions containing one or both of the hydrate forms.

6562974, May 13, 2003

Jan 29, 2001

09/771899

Frederick Dana Cazer - Earlville NY
William Douglas Cramer - Cincinnati OH
Dennis Michael Billings - Norwich NY
Gregory Eugene Parry - Lawrenceville NJ

The Procter Gamble Company - Cincinnati OH

C07F 958

546 25, 562 13

The present invention relates to a novel process for making geminal bisphosphonates. The process provides for bisphosphorylation using phosphorus trihalide, phosphorous acid as a reactant/solvent, and a base as an acid acceptor/solvent. The present invention is directed to a process for making geminal bisphosphonates of the general formula: wherein Q is oxygen, âNR4â, sulfur, selenium, or a single bond; m+n is an integer from 0 to about 5, Z is a ring selected from the group consisting of pyridine, pyridazine, pyrimidine, and pyrazine; R is hydrogen, substituted or unsubstituted amino, amido, hydroxy, alkoxy, halogen, carboxylate, substituted or unsubstituted alkyl (saturated or unsaturated) having from 1 to about 6 carbon atoms, substituted or unsubstituted aryl, or substituted or unsubstituted benzyl; each R is independently, hydrogen, or substituted or unsubstituted alkyl (saturated or unsaturated) having from 1 to about 4 carbon atoms; R is one or more substituents selected from the group consisting of hydrogen, substituted or unsubstituted alkyl (saturated or unsaturated) having from 1 to about 6 carbon atoms, substituted and unsubstituted aryl, substituted and unsubstituted benzyl, hydroxy, halogen, carbonyl, alkoxy, nitro, amido, amino, substituted amino, carboxylate, and combinations thereof; R is hydrogen, substituted alkyl (saturated or unsaturated) having from 1 to about 4 carbon atoms, or acyl.

53328329, Jul 26, 1994

Aug 11, 1992

7/928140

Frederick D. Cazer - Earlville NY
Michael J. Kane - Norwich NY
Barry L. Scott - Norwich NY
Vijay Shahi - New Bombay, IN

Procter & Gamble Pharmaceuticals, Inc. - Norwich NY

C07D23340
A61K 952
A61K 31415

5483161

Nitrofurantoin particulates comprising discrete particulates of nitrofurantoin wherein: (a) said particulates are larger than about 200 mesh size; and (b) the BET surface area of said particulates is at least about 0. 2 M. sup. 2 /g. Preferably, the surface of said particulates consists essentially of nitrofurantoin monohydrate. Also preferably, said particulates comprise at least about 5%, more preferably at least about 50% of nitrofurantoin monohydrate. Preferred compositions of this invention comprise these nitrofurantoin particulates in an aqueous suspension. The nitrofurantoin particulates of this invention are highly efficacious for the delivery of nitrofurantoin in oral dosage forms.

50715470, Dec 10, 1991

Mar 23, 1990

7/498112

Frederick D. Cazer - Earlville NY
Barry L. Scott - Norwich NY
Garth E. Strobel - Smyrna NY

Separations Technology, Inc. - Wakefield RI

B01D 1508

2101982

The present invention involves a dual column chromatographic apparatus with column switching capability that is useful in any pressurized fluid chromatography system. The apparatus has at least a first and second chromatographic column, a detector, a fluid conveyance system having a multivalve arrangement, pressurizable fluid conduit assembly, and a controller. The columns are adapted for containing stationary phase or packing for separation of a multicomponent sample into one or more components. The multi-valve arrangement has a plurality of multi-port, multi-modal valves and can include an ingress-egress valve; a guard pre-column valve; detector isolation valve; a set of four, four-port, multi-modal valves; or a set of two four-port, multi-modal valves and one six-port, multi-modal valve or a first valve set and a second valve set. The two chromatographic columns, multi-valve arrangement, and detector are linked for pressurized fluid communication by the pressurized fluid conduit assembly. This conduit assembly with pressurization enables the passage of the fluid mobile phase with or without a sample into the multivalve arrangement, between the valves of the multi-valve arrangement, from and to the multi-valve arrangement and the first column, from and to the multi-valve arrangement and the detector, from and to the multi-valve arrangement and the second column, and out of the multi-valve arrangement.