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Frauke H Rininsland

from Baldwin City, KS
Age ~61
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Also known as:
Frauke D
Connected to:
Adela S Rink, 64Emma K Rink, 29Jillian Rink, 28Kevin J Rink, 58Lara M Rink, 43Monte A Rink, 58Nathaniel B Rink, 48Patricia S Rink, 49Shannon L Rink, 55Tara A Rink, 42

Frauke Rininsland Phones & Addresses

  • Baldwin City, KS
  • 720 Arkansas St, Laurence, KS 66044 (785) 856-1547
  • Lawrence, KS
  • 2357 Botulph Rd, Santa Fe, NM 87505 (505) 438-1851
  • 2556 Camino San Patricio, Santa Fe, NM 87505 (505) 438-1851 (505) 474-4263
  • 2741 Euclid Heights Blvd, Cleveland, OH 44106
  • 2928 Somerton Rd, Cleveland, OH 44118
  • Clearwater Beach, FL

Work

Company: Gyrasol technologies Feb 2007 Position: Chief scientific officer

Education

School / High School: Georg-August-Universität Göttingen 1988 to 1993

Skills

Biotechnology • Biomarkers • Antibodies • Biology • Drug Discovery • Technology Transfer • Biochemistry • Cell Biology • Lifesciences • Assay Development • Cancer • Infectious Diseases • Immunology • Genomics • Molecular Biology • Protein Chemistry • Drug Development • Stem Cells • High Throughput Screening • Cell • Monoclonal Antibodies • Biopharmaceuticals • Gene Therapy • Cell Culture • Protein Expression • Signal Transduction • In Vitro • Immunoassays • Purification • Elisa • Translational Research • Laboratory • Dna Sequencing • Virology • Laboratory Automation • Translational Medicine • Proteomics • In Vivo • Computational Biology • Drug Delivery • Microarray • Personalized Medicine • Bioinformatics • Pcr • Inflammation • Life Sciences • Sequencing • Chromatography • Hplc • Microbiology

Languages

English • German

Interests

Biology • New Technology • Drug Discovery

Industries

Translation And Localization

Public records

Vehicle Records

Frauke Rininsland

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Address:
982 N 640 Rd, Baldwin City, KS 66006
Phone:
(785) 304-3968
VIN:
3VW3L7AJ8BM132974
Make:
VOLKSWAGEN
Model:
JETTA
Year:
2011

Resumes

Resumes

Frauke Rininsland Photo 1

Principal Research And Operations Scientist

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Location:
2357 Botulph Rd, Santa Fe, NM 87505
Industry:
Translation And Localization
Work:
Gyrasol Technologies since Feb 2007
Chief Scientific Officer
QTL Biosystems - Santa Fe, NM 2000 - 2007
Director of Drug Discovery
Case Western Reserve University 1994 - 2000
Research Fellow Immunology and Cancer Gene Therapy
Education:
Georg-August-Universität Göttingen 1988 - 1993
Skills:
Biotechnology
Biomarkers
Antibodies
Biology
Drug Discovery
Technology Transfer
Biochemistry
Cell Biology
Lifesciences
Assay Development
Cancer
Infectious Diseases
Immunology
Genomics
Molecular Biology
Protein Chemistry
Drug Development
Stem Cells
High Throughput Screening
Cell
Monoclonal Antibodies
Biopharmaceuticals
Gene Therapy
Cell Culture
Protein Expression
Signal Transduction
In Vitro
Immunoassays
Purification
Elisa
Translational Research
Laboratory
Dna Sequencing
Virology
Laboratory Automation
Translational Medicine
Proteomics
In Vivo
Computational Biology
Drug Delivery
Microarray
Personalized Medicine
Bioinformatics
Pcr
Inflammation
Life Sciences
Sequencing
Chromatography
Hplc
Microbiology
Interests:
Biology
New Technology
Drug Discovery
Languages:
English
German

Business Records

Name / Title
Company / Classification
Phones & Addresses
Frauke Rininsland
Principal
Gyrasol Technologies
Commercial Physical Research, Nsk · Mfg Diagnostic Substances
2029 Becker Dr, Lawrence, KS 66047
1800 Old Pecos Trl, Santa Fe, NM 87505
(505) 310-3659

Publications

Us Patents

Fluorescent Polymer Superquenching-Based Bioassays

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US Patent:
20020150759, Oct 17, 2002
Filed:
Mar 18, 2002
Appl. No.:
10/098387
Inventors:
Robert Jones - Albuquerque NM, US
Sriram Kumaraswamy - Santa Fe NM, US
Liangde Lu - Mesa AZ, US
Frauke Rininsland - Santa Fe NM, US
Kevin Ley - Santa Fe NM, US
Wensheng Xia - Santa Fe NM, US
Duncan McBranch - Santa Fe NM, US
David Whitten - Santa Fe NM, US
International Classification:
B32B005/16
US Classification:
428/403000
Abstract:
A chemical composition including a fluorescent polymer and a receptor that is specific for both a target biological agent and a chemical moiety including (a) a recognition element, (b) a tethering element, and (c) a property-altering element is disclosed. Both the fluorescent polymer and the receptor are co-located on a support. When the chemical moiety is bound to the receptor, the property-altering element is sufficiently close to the fluorescent polymer to alter the fluorescence emitted by the polymer. When an analyte sample is introduced, the target biological agent, if present, binds to the receptor, thereby displacing the chemical moiety from the receptor, resulting in an increase of detected fluorescence. Assays for detecting the presence of a target biological agent are also disclosed.

Bio-Sensing Platforms For Detection And Quantitation Of Biological Molecules

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US Patent:
20030054413, Mar 20, 2003
Filed:
Aug 23, 2002
Appl. No.:
10/226300
Inventors:
Sriram Kumaraswamy - Santa Fe NM, US
David Whitten - Santa Fe NM, US
Duncan McBranch - Santa Fe NM, US
Frauke Rininsland - Santa Fe NM, US
Brent Burdick - Placitas NM, US
International Classification:
G01N033/53
C08B037/00
US Classification:
435/007500, 536/018700, 525/256000
Abstract:
A bioconjugate comprising a fluorescer (P) linked to a quencher (Q) by a tether (T) is provided. The tether (T) includes a segment that can recognize and interact with a target biomolecule. In the absence of a specific interaction of the bioconjugate with an enzyme or other target biomolecule recognizing the bioconjugate, the fluorescence of the polymer (P) is attenuated or modified by the relatively close proximity thereto of the quencher (Q). As a consequence of the association of the bioconjugate with the target biomolecule, a reaction can occur which results in a cleavage of the bioconjugate tether and a release of the fluorescent polymer and/or quencher. This sequence of events can be followed by an enhancement or amplification of the polymer fluorescence.

Assays For Protease Enzyme Activity

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US Patent:
20050014160, Jan 20, 2005
Filed:
Jul 18, 2003
Appl. No.:
10/621311
Inventors:
Sriram Kumaraswamy - Santa Fe NM, US
Komandoor Achyuthan - Santa Fe NM, US
Xiaobo Shi - Los Alamos NM, US
Troy Bergstedt - Cochiti NM, US
Frauke Rininsland - Santa Fe NM, US
Duncan McBranch - Santa Fe NM, US
David Whitten - Albuquerque NM, US
International Classification:
C12Q001/68
G01N033/53
C07H021/04
US Classification:
435006000, 435007500, 530391100, 536025320
Abstract:
Bioconjugates, kits and assays for detecting the activity of protease enzymes such as β-secretase and caspase enzymes are described. The bioconjugates include a tether having a segment capable of recognizing and interacting with (e.g., being cleaved by) the enzyme, a fluorescer including a plurality of fluorescent species conjugated to a first location on the tether, and a quencher conjugated to a second location on the tether. The segment capable of recognizing and interacting with the protease enzyme (e.g., β-secretase or caspase) is located between the first and second locations on the tether. The plurality of fluorescent species are associated with one another such that the quencher is capable of amplified super-quenching of the fluorescer. The assay is suitable for screening potential drugs for their efficiency in inhibiting the activity of protease enzymes such as β-secretase in a high throughput format where the potential drugs are evaluated.

Light-Activated Biocidal Polyelectrolytes

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US Patent:
20050148254, Jul 7, 2005
Filed:
Dec 16, 2004
Appl. No.:
11/012187
Inventors:
Liangde Lu - Albuquerque NM, US
Frauke Rininsland - Santa Fe NM, US
Shannon Wittenburg - Santa Fe NM, US
Komandoor Achyuthan - Santa Fe NM, US
Duncan McBranch - Santa Fe NM, US
David Whitten - Albuquerque NM, US
International Classification:
B32B005/02
US Classification:
442123000
Abstract:
Compositions including biocidal reagents and articles treated or coated therewith are described. The compositions can be used to make passive biocidal surfaces. Exemplary biocidal reagents include visible light-absorbing polyelectrolytes which act as passive biocides upon exposure to radiation, including relatively weak “background” radiation such as natural light sources (e.g., indirect sunlight) and artificial light sources. Methods of treating or coating surfaces with the compositions are also described.

Metal Mediated Fluorescence Superquenching Assays For Detection Of Phosphorylation And Dephosphorylation Of Quencher-Labeled Substrates

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US Patent:
20060292653, Dec 28, 2006
Filed:
Mar 20, 2006
Appl. No.:
11/378470
Inventors:
Frauke Rininsland - Santa Fe NM, US
Casey Stankewicz - Madison WI, US
International Classification:
C12Q 1/48
C12Q 1/42
US Classification:
435015000, 435021000
Abstract:
A method includes contacting an analyte; a phosphorylatable or dephosphorylatable substrate bound to a quencher; and a sensor that includes at least one fluorescent polymer complexed to one or more metal species; to form a composition; and determining the fluorescence of the composition, if any; wherein when the substrate is phosphorylated, an association occurs between the substrate and the sensor such that fluorescent superquenching occurs between the fluorescent polymer and the quencher.

Metal Ion Mediated Fluorescence Superquenching Assays, Kits And Reagents

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US Patent:
20070238143, Oct 11, 2007
Filed:
Sep 7, 2005
Appl. No.:
11/219673
Inventors:
Wensheng Xia - Santa Fe NM, US
Frauke Rininsland - Santa Fe NM, US
Sriram Kumaraswamy - Santa Fe NM, US
Stuart Kushon - Santa Fe NM, US
Liangde Lu - Albuquerque NM, US
Xiaobo Shi - Los Alamos NM, US
Casey Stankewicz - Santa Fe NM, US
Shannon Wittenburg - Santa Fe NM, US
Komandoor Achyuthan - Santa Fe NM, US
Duncan McBranch - Santa Fe NM, US
David Whitten - Albuquerque NM, US
International Classification:
C12Q 1/48
C12Q 1/42
C07K 14/47
US Classification:
435015000, 435021000, 530409000
Abstract:
Reagents and assays for kinase, phosphatase and protease enzyme activity which employ metal ion-phosphate ligand specific binding and fluorescent polymer superquenching are described. The assays provide a general platform for the measurement of kinase, phosphatase and protease enzyme activity using peptide and protein substrates. Reagents and assays based on DNA hybridization and reagents and assays for proteins which employ aptamers, antibodies and other ligands are also described.

Fluorescent Polymer Superquenching-Based Bioassays

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US Patent:
20080213747, Sep 4, 2008
Filed:
Sep 19, 2006
Appl. No.:
11/533193
Inventors:
Robert M. JONES - Albuquerque NM, US
Sriram KUMARASWAMY - Santa Fe NM, US
Liangde LU - Mesa AZ, US
Frauke RININSLAND - Santa Fe NM, US
Kevin LEY - Santa Fe NM, US
Wensheng XIA - Santa Fe NM, US
Duncan MCBRANCH - Santa Fe NM, US
David G. WHITTEN - Santa Fe NM, US
Assignee:
QTL BIOSYSTEMS, LLC - Santa Fe NM
International Classification:
C12Q 1/70
G01N 33/543
C12Q 1/68
G01N 33/53
G01N 33/552
US Classification:
435 5, 436518, 435 6, 436527, 436501, 436528
Abstract:
A chemical composition including a fluorescent polymer and a receptor that is specific for both a target biological agent and a chemical moiety including (a) a recognition element, (b) a tethering element, and (c) a property-altering element is disclosed. Both the fluorescent polymer and the receptor are co-located on a support. When the chemical moiety is bound to the receptor, the property-altering element is sufficiently close to the fluorescent polymer to alter the fluorescence emitted by the polymer. When an analyte sample is introduced, the target biological agent, if present, binds to the receptor, thereby displacing the chemical moiety from the receptor, resulting in an increase of detected fluorescence. Assays for detecting the presence of a target biological agent are also disclosed.

Small Molecule Fluorescent Sensors For Detection Of Post-Translationalmodifications And Protein Interactions In Bioassays

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US Patent:
20110165603, Jul 7, 2011
Filed:
Aug 26, 2009
Appl. No.:
13/061412
Inventors:
Frauke H. Rininsland - Santa Fe NM, US
Shannon Keeley Wittenburg - Santa Fe NM, US
Wendy L. Weatherford - Santa Fe NM, US
Assignee:
Gyrasol Technologies Inc. - Santa Fe
International Classification:
C12Q 1/48
C07K 7/06
C07K 7/08
C07F 9/40
C07J 51/00
C07H 23/00
C07F 9/655
C07F 5/02
C12Q 1/42
C12Q 1/37
US Classification:
435 15, 530329, 530326, 530327, 530328, 558155, 536 171, 552506, 536121, 549220, 548405, 435 21, 435 23
Abstract:
The present invention relates to novel compounds which are capable as acting as fluorescent sensors or which are precursors for these and for the use of these for the assay of biological processes such as posttranslational modifications of biological molecules such as phosphorylation, de-phosphorylation, proteolytic cleavage, phosphodiesterase mediated hydrolysis of cyclic nucleotides, methylation, acetylation of proteins peptides, DNA, lipids and the detection of biomolecule interactions (e.g., protein-protein interactions). A small molecule sensor is described which can associate to phosphorylated biological targets via metal ion—phosphate association. The association event can be monitored as fluorescence quench, sensitized emission, fluorescence polarization or a combination thereof. The sensor is useful for determining enzyme
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Frauke H Rininsland from Baldwin City, KS, age ~61 Get Report