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Francois D Nicol

from Carlsbad, CA
Age ~53
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Also known as:
Francois Elizabeth Nicol, Frencois D Nicol, Fancois Nicol, Nicol Francois
Phone and address:
3461 Camino Corte, Carlsbad, CA 92009
(760) 943-8104
Related to:
Elizabeth M Nicol, 54
Connected to:
Amy M Nicol, 60Arturo J Nicol, 59Ashley Nicol, 37Cathleen M Nicol, 58Debbie Nicol, 42Dewayne I Nicol, 46Duncan J Nicol, 76Emily Nicol, 48Ginger E Nicol, 48Holly M Nicol, 40

Francois Nicol Phones & Addresses

  • 3461 Camino Corte, Carlsbad, CA 92009 (760) 943-8104
  • 7638 Reposado Dr, Carlsbad, CA 92009 (650) 255-4054
  • San Diego, CA
  • Belmont, MA
  • 1755 Willowhaven Rd, Encinitas, CA 92024 (760) 943-8104
  • 43 Walnut St, Atherton, CA 94027 (650) 329-0325
  • Menlo Park, CA
  • Spring, TX

Resumes

Resumes

Francois Nicol Photo 1

Scientific Director, Pharmaceutical Sciences Project Leadership And Operations

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Location:
7638 Reposado Dr, Carlsbad, CA 92009
Industry:
Pharmaceuticals
Work:
Halozyme Therapeutics since Jun 2008
Associate Director, Pharmaceutical Sciences
ALZA Corporation Feb 2002 - Feb 2008
Associate Director / Sr Scientist
Transgene SA Aug 2000 - Dec 2001
Group Leader / Research Scientist
Valentis, Inc Feb 1999 - Jul 2000
Senior Scientist I
University of California, San Francisco 1994 - 1998
PhD student
Education:
Université Bordeaux I 1994 - 1998
PhD, Physical Chemistry- Joint program with the University of California, San Francisco (UCSF). Lab experience entirely at UCSF (PI: Dr. F.C. Szoka Jr.) - Elucidated in details molecular mechanisms used by model alpha-helical peptides to permeabilize biological membranes (authored 6 peer-reviewed articles, including 3 lead author publications in Biophysical Journal) - Received oral congratulations from the Jury at University of Bordeaux I (reserved to top students) Ecole nationale supérieure de Chimie et de Physique de Bordeaux 1991 - 1994
Engineering, Physics and ChemistryMS equivalence
Skills:
Protein Chemistry
Drug Delivery
Clinical Development
Gmp
Hplc
Assay Development
Formulation
Life Sciences
Purification
Cro
Cancer
Pharmaceutical Industry
Uv/Vis
Oncology
In Vivo
Validation
High Performance Liquid Chromatography
In Vitro
Cmc
Stability Testing
Regulatory Filings
Drug Development
Regulatory Submissions
Method Development
Biologics
Biotechnology Industry
Strategy
Biotechnology
Cmc Development
Project Management
New Drug Application
U.s. Food and Drug Administration
Analytical Method Validation
Languages:
French
English
Francois Nicol Photo 2

Francois Nicol

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Publications

Us Patents

Nucleic Acid Formulations For Gene Delivery And Methods Of Use

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US Patent:
7491537, Feb 17, 2009
Filed:
Nov 20, 2006
Appl. No.:
11/561847
Inventors:
Jason G Fewell - The Woodlands TX, US
Fiona MacLaughlin - Houston TX, US
Louis C Smith - Houston TX, US
Francois Nicol - Menlo Park CA, US
Alain Rolland - The Woodlands TX, US
Assignee:
Genetronics Biomedical Corporation - San Diego CA
International Classification:
C12N 15/00
C12N 15/87
A61K 31/715
C07K 1/00
US Classification:
435455, 435461, 435 691, 4353201, 544 44, 530300, 530350
Abstract:
A nucleic acid formulation for use in gene delivery comprising a nucleic acid and an anionic polymer is disclosed. Examples of the anionic polymer includes anionic amino acid polymer or poly-amino acid (such as poly-L-glutamic acid, poly-D-glutamic acid, poly-L-aspartic acid, poly-D-aspartic acid), poly-acrylic acid, polynucleotides, poly galacturonic acid, and poly vinyl sulfate.

Poloxamer And Poloxamine Compositions For Nucleic Acid Delivery

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US Patent:
20030206910, Nov 6, 2003
Filed:
Sep 3, 2002
Appl. No.:
10/234405
Inventors:
Francois Nicol - Menlo Park CA, US
Jijun Wang - Pearland TX, US
Michael Coleman - The Woodlands TX, US
Fiona MacLaughlin - Belfast, GB
Alain Rolland - San Diego CA, US
International Classification:
A61K048/00
US Classification:
424/178100, 514/044000
Abstract:
The invention features selected polymers such as poloxamer 188 (Pluronic F68), poloxamer 237 (Pluronic F87), poloxamer 401 (Pluronic L121), poloxamer 338 (Pluronic F108), Poloxamer 124 (Pluronic L44), Poloxamer 184 (L-64), and poloxamines (Tetronics 904, 908, 1107, and 90R4) that enhance expression from nucleic acids when administered into an organism, in particular to muscle, and further provides selected poloxamer formulations for delivery of nucleic acids to the liver.

Poloxamer And Poloxamine Compositions For Nucleic Acid Delivery

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US Patent:
20060013883, Jan 19, 2006
Filed:
Sep 1, 2005
Appl. No.:
11/217266
Inventors:
Francois Nicol - Menlo Park CA, US
Jijun Wang - Pearland TX, US
Michael Coleman - The Woodlands TX, US
Fiona MacLaughlin - Belfast, GB
Alain Rolland - San Diego CA, US
International Classification:
A61K 48/00
A61K 9/14
US Classification:
424486000, 514044000
Abstract:
The invention features selected polymers such as poloxamer 188 (Pluronic F68), poloxamer 237 (Pluronic F87), poloxamer 401 (Pluronic L121), poloxamer 338 (Pluronic F108), Poloxamer 124 (Pluronic L44), Poloxamer 184 (L-64), and poloxamines (Tetronics 904, 908, 1107, and 90R4) that enhance expression from nucleic acids when administered into an organism, in particular to muscle, and further provides selected poloxamer formulations for delivery of nucleic acids to the liver.

Liposome Composition For Targeting Egfr Receptor

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US Patent:
20120213844, Aug 23, 2012
Filed:
Dec 20, 2007
Appl. No.:
12/513383
Inventors:
Ken Shi Kun Huang - Castro Valley CA, US
Weiming Zhang - San Francisco CA, US
Guoyang Zhang - San Jose CA, US
Francois Nicol - Carlsbad CA, US
Anthony Huang - Saratoga CA, US
International Classification:
A61K 9/127
A61P 35/00
A61K 31/351
US Classification:
424450, 514459
Abstract:
Short oligopeptides are provide which are capable of binding to the epidermal growth factor receptor on the surface of human tumor cells. Methods for using the peptides as targeting moieties in more complex compositions, such as conjugates of cytoxins, and/or structures, such as liposomal structures, for the purposes of drug delivery are also provided.

Stable Formulations Of A Hyaluronan-Degrading Enzyme

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US Patent:
20130011378, Jan 10, 2013
Filed:
Jun 15, 2012
Appl. No.:
13/507263
Inventors:
Daniel Edward Vaughn - Encinitas CA, US
Michael James Labarre - San Diego CA, US
Christopher L. Caster - Del Mar CA, US
Francois Nicol - Carlsbad CA, US
Donghyun Kim - San Diego CA, US
International Classification:
A61K 38/47
A61P 3/10
US Classification:
424 943
Abstract:
Provided are compositions that are stable formulations of a hyaluronan-degrading enzyme or are stable co-formulations of a fast-acting insulin and a hyaluronan degrading enzyme, including a recombinant human PH20 (rHuPH20).

Stable Formulations Of A Hyaluronan-Degrading Enzyme Related Applications

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US Patent:
20130022588, Jan 24, 2013
Filed:
Jun 15, 2012
Appl. No.:
13/507262
Inventors:
Daniel Edward Vaughn - Encinitas CA, US
Michael James Labarre - San Diego CA, US
Christopher L. Caster - Del Mar CA, US
Francois Nicol - Carlsbad CA, US
Donghyun Kim - San Diego CA, US
International Classification:
A61K 38/47
A61P 3/10
US Classification:
424 943
Abstract:
Provided are compositions that are stable formulations of a hyaluronan-degrading enzyme or are stable co-formulations of a fast-acting insulin and a hyaluronan degrading enzyme, including a recombinant human PH20 (rHuPH20).

Nucleic Acid Formulations For Gene Delivery And Methods Of Use

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US Patent:
7173116, Feb 6, 2007
Filed:
Sep 3, 2002
Appl. No.:
10/234406
Inventors:
Jason Fewell - The Woodlands TX, US
Fiona MacLaughlin - Houston TX, US
Louis C. Smith - Houston TX, US
Francois Nicol - Menlo Park CA, US
Alain Rolland - The Woodlands TX, US
Assignee:
Genetronics Biomedical Corporation - San Diego CA
International Classification:
C07H 21/02
A61K 38/00
C07K 1/00
C12N 15/00
US Classification:
536 231, 536 232, 536 235, 536 2351, 536 2352, 530300, 530350, 4353201, 514 54
Abstract:
A nucleic acid formulation for use in gene delivery comprising a nucleic acid and an anionic polymer is disclosed. Examples of the anionic polymer includes aniionic amino acid polymer or poly-amino acid (such as poly-L-glutamic acid, poly-D-glutamic acid, poly-L-aspartic acid, poly-D-aspartic acid), poly-acrylic acid, polynucleotides, poly galacturonic acid, and poly vinyl sulfate.
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Francois D Nicol from Carlsbad, CA, age ~53 Get Report