US Patent:
20130090263, Apr 11, 2013
Inventors:
BP CORPORATION NORTH AMERICA INC. - Houston TX, US
Feiyu Zhang - Del Mar CA, US
Carl Abulencia - San Diego CA, US
Gerhard Frey - San Diego CA, US
Assignee:
BP CORPORATION NORTH AMERICA INC. - Houston TX
International Classification:
C07K 14/00
G01N 21/64
US Classification:
506 18, 536 231, 536 243, 536 2433, 435 912, 4353201, 4352523, 435325, 4352542, 43525411, 435348, 435419, 536 245, 435 691, 435 611, 436501, 530350, 5303879, 530395, 2504591
Abstract:
The invention is directed to polypeptides having a fluorescent activity, e.g., an auto-fluorescent activity, polynucleotides encoding the polypeptides, and methods for making and using these polynucleotides and polypeptides. The polypeptides of the invention can be used as noninvasive fluorescent markers in living cells and intact organs and animals. The polypeptides of the invention can be used as, e.g., in vivo markers/tracers of gene expression and protein localization, activity indicators, fluorescent resonance energy transfer (FRET) markers, cell lineage markers/tracers, reporters of gene expression and as markers/tracers in protein-protein interactions.