Evangelia Chnari

20230072250, Mar 9, 2023

Nov 11, 2022

17/985183

- Edison NJ, US
Andrew Madans - Jersey City NJ, US
Abigail Phipps - East Brunswick NJ, US
Thomas Tylutki - Rahway NJ, US
Todd Nilsen - Howell NJ, US
Yen-Chen Huang - East Brunswick NJ, US
Evangelia Chnari - Scotch Plains NJ, US

A61L 27/38

Compositions including a first soft tissue-derived matrix and a second soft tissue-derived matrix are provided, as well as methods of making such compositions. In some embodiments, the composition comprises delipidated, decellularized adipose tissue-derived matrix and delipidated, decellularized fascial tissue-derived matrix, which may be combined in various proportions. Such adipose-fascia matrix compositions provide improved volume retention when implanted into a patient. The composition may further include exogenous cells or other substances, and/or a carrier. The composition is suitable for use in plastic surgery procedures, including reconstructive or cosmetic surgery procedures, as well as procedures for wound treatment and tissue regeneration. The methods for making the compositions may involve separation of first and second soft tissues from one another, followed by performing one or more treatments on the separated soft tissues, then combining the treated soft tissues and, optionally, performing one or more additional treatments on the combined soft tissues.

20230068127, Mar 2, 2023

Aug 23, 2022

17/893467

- Edison NJ, US
Evangelia Chnari - Scotch Plains NJ, US
Jeffrey Cartmell - Freehold NJ, US

A61F 2/12

Diversified grafts suitable for use in repair and reconstruction procedures are provided. Some diversified grafts comprise two or more heterogenous features which form regions having different preferred properties. A diversified graft useful for pre-pectoral breast reconstruction, meshing is provided on an upper pole of the diversified graft and a plurality of slits arranged in particular patterns is provided on a lower pole of the graft, whereby the upper pole has a greater expansion ability and the lower pole has lesser degree of expansion ability but maintains greater load bearing capacity which is necessary to support the lower pole of the breast undergoing reconstruction, while allowing for fluid egress. In other embodiments, the diversified graft comprises two or more components which are combined by attaching them to each other to form a larger graft of the required size. The components may be smaller pieces of the same material or different materials.

20230057906, Feb 23, 2023

Jan 14, 2021

17/792546

- Edison NJ, US
Eric J. Semler - Morganville NJ, US
Mat Citro - Matawan NJ, US
Evangelia Chnari - Scotch Plains NJ, US

A61L 27/36

Multiple component grafts are provided for treatment of tissue defects and comprise two or more components, each of which is a tissue-derived matrix and at least two of which are derived from different types of tissue. For example, a first component may be a matrix derived from cartilage tissue such as cartilage fibers with or without viable cells, cartilage particles with or without viable cells, or combinations of any two or more such cartilage-derived matrices. A second component may be a matrix derived from bone tissue such as mineralized or demineralized cortical bone fibers, viable cancellous bone matrix (e.g., cryopreserved or lyophilized chips, particulates, powder, sheets, putty, flowable fluid, etc.), demineralized or demineralized cancellous bone matrix (chips, particulates, powder, sheets, putty, flowable fluid, etc.), or combinations of any two or more of such bone-derived matrices. Also provided are methods for making and using such multiple component grafts.

20210106725, Apr 15, 2021

Dec 22, 2020

17/130137

- Edison NJ, US
Andrew Madans - Jersey City NJ, US
Abigail Phipps - East Brunswick NJ, US
Thomas Tylutki - Rahway NJ, US
Todd Nilsen - Howell NJ, US
Yen-Chen Huang - East Brunswick NJ, US
Evangelia Chnari - Scotch Plains NJ, US

A61L 27/38

Compositions including a first soft tissue-derived matrix and a second soft tissue-derived matrix are provided, as well as methods of making such compositions. In some embodiments, the composition comprises dilapidated, decellularized adipose tissue-derived matrix and dilapidated, decellularized fascial tissue-derived matrix, which may be combined in various proportions. Such adipose-fascia matrix compositions provide improved volume retention when implanted into a patient. The composition may further include exogenous cells or other substances, and/or a carrier. The composition is suitable for use inplastic surgery procedures, including reconstructive or cosmetic surgery procedures, as well as procedures for wound treatment and tissue regeneration. The methods for making the compositions may involve separation of first and second soft tissues from one another, followed by performing one or more treatments on the separated soft tissues, then combining the treated soft tissues and, optionally, performing one or more additional treatments on the combined soft tissues.

20200376163, Dec 3, 2020

Aug 19, 2020

16/997048

- Edison NJ, US
Abigail Phipps - East Brunswick NJ, US
Anouska Dasgupta - North Brunswick NJ, US
Evangelia Chnari - Scotch Plains NJ, US
Eric Semler - Morganville NJ, US

A61L 27/36
A61L 27/38

The present invention relates generally to tissue forms useful as grafts or implants and derived from membranous tissue. The tissue forms may contain viable endogenous cells. The tissue forms may be sheets or mini sheets, each having quadrilateral, circular, polygonal, or irregular shapes. The sheet tissue form may have a generally quadrilateral shape, with an average length of about 1 to about 20 centimeters and an average width of about 1 to about 20 centimeters. The mini sheet tissue form may have a generally quadrilateral shape, with an average length of about 0.5 to about 9 millimeters and an average width of about 0.5 to about 9 millimeters. A mixture of the mini sheet tissue form and a liquid, such as cryopreservation fluid, saline or buffer solution, is flowable, which means the mixture will pass through a luer-slip tip syringe, or a gauge needle.

20190298885, Oct 3, 2019

May 31, 2019

16/428505

- Edison NJ, US
Andrew Madans - Jersey City NJ, US
Abigail Phipps - East Brunswick NJ, US
Thomas Tylutki - Rahway NJ, US
Todd Nilsen - Howell NJ, US
Yen-Chen Huang - East Brunswick NJ, US
Evangelia Chnari - Scotch Plains NJ, US

A61L 27/38

Compositions including a first soft tissue-derived matrix and a second soft tissue-derived matrix are provided, as well as methods of making such compositions. In some embodiments, the composition comprises delipidated, decellularized adipose tissue-derived matrix and delipidated, decellularized fascial tissue-derived matrix, which may be combined in various proportions. Such adipose-fascia matrix compositions provide improved volume retention when implanted into a patient. The composition may further include exogenous cells or other substances, and/or a carrier. The composition is suitable for use inplastic surgery procedures, including reconstructive or cosmetic surgery procedures, as well as procedures for wound treatment and tissue regeneration. The methods for making the compositions may involve separation of first and second soft tissues from one another, followed by performing one or more treatments on the separated soft tissues, then combining the treated soft tissues and, optionally, performing one or more additional treatments on the combined soft tissues.

20170348088, Dec 7, 2017

Jun 3, 2016

15/173286

- Edison NJ, US
Todd J. Nilsen - Howell NJ, US
Evangelia Chnari - Scotch Plains NJ, US
Aldona J. Spiegel - Houston TX, US
Michael Locarno - Kinnelon NJ, US
Gregory P. Adams - Wall NJ, US

MUSCULOSKELETAL TRANSPLANT FOUNDATION - Edison NJ

A61F 2/12
A61F 2/10
A61F 2/00

A dermal tissue allograft includes a dermal matrix having a profile including first and second vertices, a first imaginary axis extending between the first and second vertices, a first peripheral edge extending along a continuous path from the first vertex to the second vertex on a first side of the first imaginary axis, and a second peripheral edge extending along a continuous path from the first vertex to the second vertex on a second side of the first imaginary axis. The first peripheral edge includes an apogee, a convex portion, and a concave portion. The convex and concave portions meet at a transition point located on the first peripheral edge between its apogee and the second vertex. The second peripheral edge includes an apogee and is convex. The second perpendicular distance is greater than the first perpendicular distance. The dermal matrix has a substantially uniform thickness across its profile.

20170021058, Jan 26, 2017

Jul 22, 2016

15/217409

- Edison NJ, US
Asia Ivery - Hammonds Plains, CA
Bryan Choi - San Marcos CA, US
Benjamin Schilling - Jersey City NJ, US
Manh-Dan Ngo - Matawan NJ, US
Evangelia Chnari - Scotch Plains NJ, US
Todd Nilsen - Howell NJ, US

MUSCULOSKELETAL TRANSPLANT FOUNDATION - Edison NJ

A61L 27/36
A61L 27/54
A61L 27/38
C12N 5/077
C12N 5/0775

A composition including delipidated, decellularized adipose tissue and delipidated, decellularized fascial tissue is provided. The composition may further include exogenous tissuegenic cells, an exogenous growth-inductive substance, and/or a carrier. The composition is suitable for implantation into a living body in plastic surgery procedures, including reconstructive or cosmetic surgery procedures, wound care procedures or other procedures of regenerative medicine. A method of preparing an acellular soft tissue-derived matrix from adipose tissue and fascial tissue is also provided. The method involves preparing a delipidated, decellularized adipose-derived matrix by delipidizing the adipose tissue and decellularizing the adipose tissue; preparing a delipidated, decellularized fascia-derived matrix by delipidizing the fascial tissue and decellularizing the fascial tissue; and combining the delipidated, decellularized adipose-derived matrix and the delipidated, decellularized fascia-derived matrix to produce said acellular soft tissue-derived matrix. The resulting Acellular soft tissue-derived matrix may be partially dried, substantially dried, or not dried.