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Ethan C Settembre

from Lexington, MA
Age ~48
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Also known as:
Settembre Settembre
Phone and address:
1430 Massachusetts Ave, Lexington, MA 02420
Related to:
Marjorie B SettembreJohn SettembreAmelia SettembreJonathan Baker, 41Norman Barrier
Connected to:
Nidia E Settembre, 31Rose M Settembre, 63Scott A Settembro, 38Adriana S Settenhofer, 56Denice E Settepani, 73Aimee L Setter, 38Charles Setter, 101Dana C Setter, 63Dolores L Settera, 91Glenn B Setterberg, 93

Ethan Settembre Phones & Addresses

  • 1430 Massachusetts Ave, Lexington, MA 02420
  • 85 Grafton St, Arlington, MA 02474
  • 405 Lake St, Ithaca, NY 14850 (607) 269-0542
  • Monroe, NY

Publications

Us Patents

Method For Generating A Parvovirus B19 Virus-Like Particle

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US Patent:
20130273109, Oct 17, 2013
Filed:
Apr 7, 2011
Appl. No.:
13/639820
Inventors:
Ethan Settembre - Lexington MA, US
Doris Coit - Petaluma CA, US
Philip R. Dormitzer - Weston MA, US
Assignee:
NOVARTIS AG - Basel
International Classification:
A61K 39/23
US Classification:
4242331, 435 691, 4353201, 4352542, 435348, 435325, 435349, 4352523, 4352581, 435 5
Abstract:
The invention provides a process for generating parvovirus VP1/VP2 virus like particles (VLPs). The invention further provides methods for purification of the parvovirus VLPs and immunogenic compositions that contain the VLPs. The invention also includes recombinant nucleic acid molecules that encode parvovirus VP1 and VP2, and host cells that contain the recombinant nucleic acids.

Norovirus Derived Immunogenic Compositions And Methods

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US Patent:
20130171185, Jul 4, 2013
Filed:
Jul 5, 2011
Appl. No.:
13/808157
Inventors:
Ethan Settembre - Lexington MA, US
Doris Coit - Petaluma CA, US
Philip R. Dormitzer - Weston MA, US
International Classification:
C07K 14/08
A61K 39/295
US Classification:
4241921, 530350, 536 234, 4353201, 435348, 435325, 435349, 4352523, 4352542, 4352581, 435 693
Abstract:
The invention relates to chimeric norovirus VP1 proteins containing the S-domain of VP1 of a first norovirus strain and a P-domain that contains at least a portion of the P-domain of VP1 of a second norovirus strain. The invention also relates to nucleic acids that encode the chimeric VP1 proteins, virus-like particles that contain a chimeric norovirus VP1 protein, and to immunogenic compositions.

Influenza Potency Assays

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US Patent:
20200200764, Jun 25, 2020
Filed:
Jul 29, 2019
Appl. No.:
16/524280
Inventors:
- Berkshire, GB
Ethan SETTEMBRE - Cambridge MA, US
Zihao WANG - Cambridge MA, US
International Classification:
G01N 33/68
C12N 7/00
A61K 39/145
G01N 33/569
Abstract:
The present application discloses stability-indicating potency assays for influenza vaccines.

Cytomegalovirus Antigens

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US Patent:
20180265551, Sep 20, 2018
Filed:
Dec 7, 2015
Appl. No.:
15/533483
Inventors:
- Rixensart, BE
Sumana CHANDRAMOULI - Cambridge MA, US
Ethan C. SETTEMBRE - Cambridge MA, US
Assignee:
GLAXOSMITHKLINE BIOLOGICALS SA - Rixensart
International Classification:
C07K 14/005
Abstract:
The invention generally relates to recombinant human cytomegalovirus (CMV) gB proteins and immunogenic fragments thereof, which do not comprise a transmembrane (TM) domain; and comprise one or more mutations that reduce the aggregation between the monomeric trimers of gB, and/or adhesion of the monomeric trimer of gB to the host cell.

Influenza Potency Assays

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US Patent:
20180196061, Jul 12, 2018
Filed:
Jul 7, 2016
Appl. No.:
15/741816
Inventors:
- Berkshire, GB
Ethan SETTEMBRE - Cambridge MA, US
Zihao WANG - Cambridge MA, US
International Classification:
G01N 33/68
G01N 33/569
A61K 39/145
C12N 7/00
Abstract:
The present application discloses stability-indicating potency assays for influenza vaccines.

Rotavirus Particles With Chimeric Surface Proteins

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US Patent:
20160188790, Jun 30, 2016
Filed:
Jul 8, 2014
Appl. No.:
14/900829
Inventors:
- Basel, CH
- Boston MA, US
- Waltham MA, US
Junhua Pan - Brookline MA, US
Ethan Settembre - Cambridge MA, US
International Classification:
G06F 19/16
G06F 19/12
C12Q 1/02
C07K 14/005
C12N 7/00
Abstract:
The present invention relates to the use of rotavirus particles for displaying a heterologous protein, alone or in complex with another molecule. The invention further relates to methods that employ these modified rotavirus particles to rapidly determine the structure of the heterologous protein or the complex using cryo-electron microscopy (cryo-EM). The invention also relates to a method of immunising a patient, wherein said method comprises administering to the patient the modified rotavirus particles of the invention.

Immunogenic Combination Compositions And Uses Thereof

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US Patent:
20140227346, Aug 14, 2014
Filed:
Jul 6, 2012
Appl. No.:
14/130899
Inventors:
Andrew Geall - Littleton MA, US
Ethan Settembre - Lexington MA, US
International Classification:
A61K 35/76
US Classification:
424450, 424451, 424489, 4241861
Abstract:
This invention generally relates to immunogenic compositions that comprise an RNA component and a polypeptide component. Immunogenic compositions that deliver antigens in two different forms—a first antigen from a pathogen, in RNA-coded form; and a second antigen from a different pathogen, in polypeptide form—are effective in inducing immune response to both pathogens.

Compositions And Methods For Assessing Functional Immunogenicity Of Parvovirus Vaccines

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US Patent:
20140170187, Jun 19, 2014
Filed:
Jul 25, 2012
Appl. No.:
14/234648
Inventors:
Ethan Settembre - Lexington MA, US
Sumana Chandramouli - Winchester MA, US
International Classification:
C07K 14/005
G01N 33/569
A61K 39/23
US Classification:
4242331, 530350, 536 2372, 435 792
Abstract:
The present invention is directed to mutant parvovirus VP1 unique region polypeptides, compositions comprising such polypeptides, methods of making such compositions, as well as methods for identifying the likely presence of parvovirus-neutralizing antibodies, and methods for assessing the functional immunogenicity of parvovirus vaccines and measuring a correlate of efficacy to assess a treatment for parvovirus infection.
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Ethan C Settembre from Lexington, MA, age ~48 Get Report