Inventors:
Patrick W. Gray - San Francisco CA
Ernst H. Rinderknecht - San Carlos CA
Assignee:
Genentech, Inc. - South San Francisco CA
International Classification:
A61K 3821
US Classification:
424 855, 514 12, 530351, 435 6951, 536 2352
Abstract:
The present invention relates to novel, stable recombinant gamma interferons exhibiting in greater or less degree the antiviral and antiproliferative activity in humans and pH 2 labile properties characteristic of native human gamma interferon. The amino acid sequence of such an interferon comprises, from the N-terminus: wherein X is a methionine residue or hydrogen and Y is a glutamine residue, or, where X is hydrogen, Y is either a glutamine or a pyroglutamate residue.