US Patent:
20090263325, Oct 22, 2009
Inventors:
David Brandon Whitt - Long Beach CA, US
Andrew Michael Leach - Clifton Park NY, US
Peter Miller - New London CT, US
Eric Telfeyan - Guilderland NY, US
Assignee:
GENERAL ELECTRIC COMPANY - Schenectady NY
International Classification:
A61K 49/10
B01J 19/00
Abstract:
Methods and apparatuses that facilitate dissolving a hyperpolarized agent within a polarizer and transporting it to a receiver is provided. The methods include delivering water to a hyperpolarized agent contained within a polarizer, forming a hyperpolarized aqueous solution, transporting the aqueous solution through a fluid path system out of the polarizer, filtering the aqueous solution through a partical size exclusion filter to a receiver, and modifying the pH of the filtered hyperpolarized aquous solution with a dissolution medium contained in the receiver. Also disclosed herein are apparatuses for dissolving a hyperpolarized agent comprising a vial for containing a hyperpolarized imaging agent therein, a dissolution fluid path, a delivery fluid path, a particle size exclusion filter, and a receiver connected to the particle size exclusion filter and positioned to receive the filtered aqueous solution of the hyperpolarized imaging agent.