Resumes
Resumes
Ella Sklan Phones & Addresses
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Menlo Park, CA
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267 Curtner Ave, Palo Alto, CA 94306 (650) 843-0383
Publications
Us Patents
Methods And Compositions For Identifying Anti-Hcv Agents
View pageUS Patent:
20080261906, Oct 23, 2008
Filed:
Aug 24, 2007
Appl. No.:
11/844993
Inventors:
Jeffrey Glenn - Palo Alto CA, US
Ella Sklan - Stanford CA, US
Kirk Staschke - Indianapolis IN, US
Tina Myers Oakes - Indianapolis IN, US
Ella Sklan - Stanford CA, US
Kirk Staschke - Indianapolis IN, US
Tina Myers Oakes - Indianapolis IN, US
International Classification:
A61K 31/7052
C12Q 1/70
A61P 31/12
C12Q 1/70
A61P 31/12
US Classification:
514 44, 435 5
Abstract:
The invention features methods and compositions for screening for agents that modulate replication of a virus, particularly Flaviviridae virus (particularly hepatitis C virus (HCV)), where the methods provide for detection of agents that modulate the binding of TBC and NS5A, the inhibition of TBC activity, inhibition of Rab1 activity, and/or the expression of the TBC protein and/or Rab1 protein. The invention also features methods of controlling viral replication, and agents useful in such methods.