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Elena I Kostik

from Chelmsford, MA
Age ~61
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Related to:
William P Mccauley, 72William P Mccauley, 84Kenneth J Kostik, 66
Connected to:
Kristin A Kostik, 58Melissa Kostik, 50Peter J Kostik, 71Diba L Kostin, 50Natalia A Kostina, 77Peter Kostin, 37Vladimir K Kostin, 37Dana R Kostiner, 56Rickie L Kostiner, 37John M Kostis, 74

Elena Kostik Phones & Addresses

  • Chelmsford, MA
  • 71 Morningside Dr, Arlington, MA 02474 (781) 541-0054
  • 32 School St, Arlington, MA 02476 (781) 641-1776
  • 46 Forest St, Arlington, MA 02476 (781) 641-1776
  • 10 Park St, Arlington, MA 02474 (781) 641-1776
  • 10B Park St, Arlington, MA 02474 (781) 641-1776

Work

Company: Deciphera pharmaceuticals Jan 2020 Position: Associate director, process chemistry ms and t

Education

Degree: Master of Science, Masters School / High School: Saint Petersburg State University 1982 to 1987 Specialities: Chemistry

Skills

Drug Discovery • Organic Chemistry • Medicinal Chemistry • Physical Organic Chemistry • Drug Substance Process Development • Technology Transfer To Cmo • Cmc • Gmp • Ind • Pharmaceutical Industry • Chemistry • Organic Synthesis • Lead Change • Ind and Technical Writing • Solid Oral Dosage Forms • Characterization • Process Simulation • Problem Solving • Cmo Management • Pharmaceutical Process Development • Cross Functional Team Leadership • Clinical Trials

Industries

Pharmaceuticals

Resumes

Resumes

Elena Kostik Photo 1

Associate Director, Process Chemistry Ms And T

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Location:
Arlington, MA
Industry:
Pharmaceuticals
Work:
Deciphera Pharmaceuticals
Associate Director, Process Chemistry Ms and T
International Partnership For Microbicides
Associate Director, Process Chemistry
Tesaro, Inc. Jun 2016 - Dec 2016
Associate Director, Lifecycle Management
Synta Pharmaceuticals 2013 - 2016
Associate Director, Chemical Development and Manufacturing
Synta Pharmaceuticals 2009 - 2013
Principal Scientist Process Chemistry
Education:
Saint Petersburg State University 1982 - 1987
Master of Science, Masters, Chemistry Saint Petersburg State University
Doctorates, Doctor of Philosophy, Organic Chemistry Russian Academy of Sciences, Ural Section
Doctorates, Doctor of Philosophy, Organic Chemistry
Skills:
Drug Discovery
Organic Chemistry
Medicinal Chemistry
Physical Organic Chemistry
Drug Substance Process Development
Technology Transfer To Cmo
Cmc
Gmp
Ind
Pharmaceutical Industry
Chemistry
Organic Synthesis
Lead Change
Ind and Technical Writing
Solid Oral Dosage Forms
Characterization
Process Simulation
Problem Solving
Cmo Management
Pharmaceutical Process Development
Cross Functional Team Leadership
Clinical Trials

Publications

Us Patents

Pyrimidine Compounds

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US Patent:
6858606, Feb 22, 2005
Filed:
Nov 26, 2002
Appl. No.:
10/305039
Inventors:
Lijun Sun - Harvard MA, US
Mitsunori Ono - Lexington MA, US
Elena Kostik - Arlington MA, US
Yumiko Wada - Waltham MA, US
Assignee:
Synta Pharmaceutical Corp. - Lexington MA
International Classification:
C07D417/04
C07D413/04
C07D409/04
C07D405/04
C07D401/04
US Classification:
5142278, 5142315, 514272, 514275, 544317, 544320, 544321, 544326, 544328, 544330, 544331, 544111
Abstract:
This invention features pyrimidine compounds of formula (I): Ris in which one of Rand Ris H or alkyl, and the other is aryl or heteroaryl optionally substituted with Rand R; each of Rand Ris H; Ris H, alkyl, aryl, heteroaryl, cyclyl, heterocyclyl, or alkylcarbonyl; Ris H or alkyl; n is 0, 1, 2, 3, 4, 5, or 6; X is NR; Y is covalent bond, CH, C(O), C═N—R, C═N—OR, C═N—SR, O, S, S(O), S(O), or NR; Z is N or CH; one of U and V is N, and the other is CR; and W is O, S, S(O), S(O), NR, or NC(O)R; in which Ris H, alkyl, aryl, heteroaryl, cyclyl, heterocyclyl, or alkylcarbonyl; Ris halogen, CN, alkyl alkyloxy, alkylcarbonyl, alkyloxycarbonyl, aryloxycarbonyl, heteroaryloxycarbonyl, hydroxyalkyl, alkylamino, or alkylaminocarbonyl; Ris halogen, CN, hydroxyl, alkyl, aryl, heteroaryl, alkoxyl, aryloxyl, or heteroaryloxyl; and m is 0, 1, 2, 3, or 4. The pyrimidine compounds can be used to treat an IL-12 overproduction-related disorder (e. g. , rheumatoid arthritis, sepsis, Crohn's disease, multiple sclerosis, psoriasis, or insulin-dependent diabetes mellitus).

Pyrimidine Compounds

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US Patent:
6958332, Oct 25, 2005
Filed:
Sep 5, 2003
Appl. No.:
10/655672
Inventors:
Lijun Sun - Harvard MA, US
Mitsunori Ono - Lexington MA, US
Teresa Przewloka - Tewksbury MA, US
Elena Kostik - Arlington MA, US
Yumiko Wada - Waltham MA, US
Assignee:
Synta Pharmaceuticals Corp. - Lexington MA
International Classification:
A61K031/506
A61P003/10
A61P017/06
A61P019/02
A61P025/28
US Classification:
5142278, 5142358, 51425214, 514269, 514275, 544320, 544324, 544336, 544 59, 544111
Abstract:
This invention features pyrimidine compounds of formula (I): each of Rand Ris H; Ris H, alkyl, aryl, heteroaryl, cyclyl, heterocyclyl, or alkylcarbonyl; Ris H or alkyl; n is 0, 1, 2, 3, 4, 5, or 6; X is NR; Y is covalent bond, CH, C(O), C═N—R, C═N—OR, C═N—SR, O, S, S(O), S(O), or NR; Z is N or CH; one of U and V is N, and the other is CR; and W is O, S, S(O), S(O), NR, or NC(O)R; in which each of Rand R, independently, is H, alkyl, aryl, heteroaryl; and Ris H, alkyl, aryl, heteroaryl, cyclyl, heterocyclyl, or alkylcarbonyl.

Pyrimidine Compounds

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US Patent:
7067514, Jun 27, 2006
Filed:
Sep 5, 2003
Appl. No.:
10/656671
Inventors:
Mitsunori Ono - Lexington MA, US
Shijie Zhang - Nashua NH, US
Teresa Przewloka - Tewksbury MA, US
Keizo Koya - Chestnut Hill MA, US
Elena Kostik - Arlington MA, US
Yuniko Wada - Waltham MA, US
Lijun Sun - Harvard MA, US
Weiwen Ying - Ayer MA, US
Assignee:
Synta Pharmaceuticals Corp. - Lexington MA
International Classification:
A61K 31/506
A61P 3/10
A61P 17/06
A61P 19/02
A61P 25/28
US Classification:
5142278, 5142358, 51425214, 514269, 514275
Abstract:
This invention features pyrimidine compounds of formula (I):.

Heterocyclic Compounds

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US Patent:
7122665, Oct 17, 2006
Filed:
Oct 14, 2003
Appl. No.:
10/686505
Inventors:
Lijun Sun - Harvard MA, US
Mitsunori Ono - Lexington MA, US
Yumiko Wada - Billerica MA, US
Weiwen Ying - Ayer MA, US
Teresa Przewloka - Tewksbury MA, US
Elena Kostik - Arlington MA, US
Assignee:
Synta Pharmaceuticals Corp. - Lexington MA
International Classification:
C07D 413/14
C07D 413/04
C07D 487/02
US Classification:
544118, 544236
Abstract:
This invention features a compound of formula (I):.

Bis(Thio-Hydrazide Amide) Salts For Treatment Of Cancers

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US Patent:
7385084, Jun 10, 2008
Filed:
Jun 20, 2005
Appl. No.:
11/157213
Inventors:
Keizo Koya - Chestnut Hill MA, US
Lijun Sun - Harvard MA, US
Elena Kostik - Arlington MA, US
Farid Vaghefi - Watertown MA, US
Shoujun Chen - Bedford MA, US
Noriaki Tatsuta - Lexington MA, US
Guiqing Liang - Concord MA, US
Takayo Inoue - Malden MA, US
Zhi-Qiang Xia - Acton MA, US
Assignee:
Synta Pharmaceutical Corp. - Lexington MA
International Classification:
C07C 327/38
A61K 31/16
US Classification:
564 74, 514422, 514599, 548518
Abstract:
Disclosed are bis(thio-hydrazide amide) disalts, which are represented by Structural Formula (I):Y is a covalent bond or a substituted or unsubstituted straight chained hydrocarbyl group. R-Rare independently —H, an aliphatic group, a substituted aliphatic group, an aryl group or a substituted aryl group, or Rand Rtaken together with the carbon and nitrogen atoms to which they are bonded, and/or Rand Rtaken together with the carbon and nitrogen atoms to which they are bonded, form a non-aromatic heterocyclic ring optionally fused to an aromatic ring. Z is —O or —S. M is a pharmaceutically acceptable monovalent cation and M is a pharmaceutically acceptable divalent cation. Also, disclosed are pharmaceutical compositions comprising a bis(thio-hydrazide amide) disalt described above. Further disclosed are methods of treating a subject with cancer. The methods comprise the step of administering an effective amount of a bis(thio-hydrazide amide) disalt described above.

Heterocyclic Compounds

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US Patent:
7410990, Aug 12, 2008
Filed:
Oct 3, 2006
Appl. No.:
11/542963
Inventors:
Lijun Sun - Harvard MA, US
Mitsunori Ono - Lexington MA, US
Yumiko Wada - Billerica MA, US
Weiwen Ying - Ayer MA, US
Teresa Przewloka - Tewksbury MA, US
Elena Kostik - Arlington MA, US
Assignee:
Synta Pharmaceuticals Corp. - Lexington MA
International Classification:
A61K 31/4184
A61K 31/5377
C07D 265/30
C07D 235/30
US Classification:
514395, 5142325, 544 80, 5483044, 5483047
Abstract:
This invention features a compound of formula (I):.

Pyrimidine Compounds

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US Patent:
7465725, Dec 16, 2008
Filed:
Jul 29, 2005
Appl. No.:
11/193001
Inventors:
Mitsunori Ono - Lexington MA, US
Lijun Sun - Harvard MA, US
Teresa Przewloka - Tewksbury MA, US
Shijie Zhang - Nashua NH, US
Elena Kostik - Arlington MA, US
Weiwen Ying - Ayer MA, US
Yumiko Wada - Billerica MA, US
Keizo Koya - Chestnut Hill MA, US
Assignee:
Synta Pharmaceuticals Corp. - Lexington MA
International Classification:
A61K 31/506
A61P 17/06
A61P 19/02
A61P 25/28
C07D 401/04
C07D 405/04
C07D 413/04
C07D 417/04
C07D 239/24
US Classification:
5142278, 5142315, 514256, 514269, 544317, 544320, 544336, 544 50, 544111
Abstract:
This invention features pyrimidine compounds of formula (I):Ris.

Pyrimidine Compounds

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US Patent:
7470681, Dec 30, 2008
Filed:
Jul 29, 2005
Appl. No.:
11/193002
Inventors:
Lijun Sun - Harvard MA, US
Mitsunori Ono - Lexington MA, US
Teresa Przewloka - Tewksbury MA, US
Elena Kostik - Arlington MA, US
Yumiko Wada - Billerica MA, US
Assignee:
Synta Pharmaceuticals Corp. - Lexington MA
International Classification:
A61K 31/506
A61P 17/06
A61P 19/02
A61P 25/28
C07D 401/04
C07D 405/04
C07D 413/04
C07D 417/04
C07D 239/24
US Classification:
5142278, 5142315, 514256, 514269, 514275, 544317, 544320, 544336, 544 50, 544111
Abstract:
This invention features pyrimidine compounds of formula (I):.
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Elena I Kostik from Chelmsford, MA, age ~61 Get Report