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Douglas M Heithoff

from Santa Barbara, CA
Age ~56
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Also known as:
Douglas Matthew Heithoff, Douglas M Heighoff, Dousas Heighoff
Phone and address:
726 Alameda Padre Serra, Santa Barbara, CA 93103
Connected to:
Lynne A Heithoff, 58Alfred H Heitkamp, 90Christina Heitkamp, 30Harold R Heitkamp, 71Keith R Heitkamp, 58Michelle L Heitkamp, 45Norbert W Heitkamp, 77Patrick J Heitkamp, 55Hillary W Heitkemper, 53Louis J Heitlinger, 92

Douglas Heithoff Phones & Addresses

  • 726 Alameda Padre Serra, Santa Barbara, CA 93103
  • 785 Camino Del Sur, Goleta, CA 93117

Education

Degree: High school graduate or higher

Resumes

Resumes

Douglas Heithoff Photo 1

Research Biologist

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Position:
Project Scientist at UC Santa Barbara
Location:
Santa Barbara, California Area
Industry:
Research
Work:
UC Santa Barbara since Jul 2008
Project Scientist
Education:
University of California, Santa Barbara
University of Illinois at Urbana-Champaign
Douglas Heithoff Photo 2

Project Scientist

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Location:
Santa Barbara, CA
Industry:
Research
Work:
Uc Santa Barbara
Project Scientist
Education:
University of California
Uc Santa Barbara
Doctorates, Doctor of Philosophy, Microbiology, Philosophy University of Illinois at Urbana - Champaign
Bachelors, Bachelor of Science, Biology
Skills:
Molecular Biology
Cell Culture
Biochemistry
Pcr
Western Blotting
Event Planning
Microsoft Word
Research
Protein Purification

Publications

Us Patents

Method And Probes For The Identification Of Microbial Genes Specifically Induced During Host Infection

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US Patent:
6548246, Apr 15, 2003
Filed:
Nov 17, 1998
Appl. No.:
09/194036
Inventors:
Michael J. Mahan - Santa Barbara CA
Christopher P. Conner - Santa Barbara CA
Douglas M. Heithoff - Goleta CA
Assignee:
The Regents of the University of California - Oakland CA
International Classification:
C12Q 168
US Classification:
435 6, 435471, 435477, 435479, 435480
Abstract:
The present invention relates to a class of microbial coding sequences the transcription or cotranscription of which is specifically induced during microbial infection of a host. These particular coding sequences or defined regions thereof may be used as probes to identify and isolate microbial virulence genes. The products of these virulence genes will provide potential targets for the development of vaccines or antimicrobial agents.

Method Of Reducing Bacterial Proliferation

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US Patent:
7026155, Apr 11, 2006
Filed:
Aug 9, 2001
Appl. No.:
09/928227
Inventors:
Michael J. Mahan - Santa Barbara CA, US
Douglas M. Heithoff - Goleta CA, US
David A. Low - Goleta CA, US
Robert L Sinsheimer - Santa Barbara CA, US
Assignee:
Regents of the University of California - Oakland CA
International Classification:
G01N 33/53
US Classification:
4352521, 4353201, 4242001
Abstract:
Bacteria and in particular pathogenic bacteria are treated in a manner which alters the bacteria's native level or activity of DNA methyltransferase (Dam). The alteration results in a change in the bacteria's native level of methylation of adenine in a GATC tetranucleotide which inhibits virulence of the bacteria. Thus, compounds which inhibit proliferation of bacteria are useful in treating bacterial infections.

Method Of Creating Antibodies And Compositions Used For Same

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US Patent:
20020068068, Jun 6, 2002
Filed:
Aug 9, 2001
Appl. No.:
09/927765
Inventors:
Michael Mahan - Santa Barbara CA, US
Douglas Heithoff - Goleta CA, US
David Low - Goleta CA, US
Robert Sinsheimer - Santa Barbara CA, US
International Classification:
A61K039/108
A61K039/112
A61K039/106
A61K039/02
US Classification:
424/200100, 424/257100, 424/258100, 424/261100
Abstract:
The present invention is directed towards compositions containing pathogenic bacteria (e.g. Haemophilus, , and/or Salmonella) having non-reverting genetic mutations which alter activity of DNA adenine methylase (Dam) and methods using these compositions to elicit an immune response to produce highly specific antibodies. The invention also provides methods for preparing vaccines as well as screening methods to identify agents which may have anti-bacterial activity.

Attenuated Bacteria With Altered Dna Adenine Methylase Activity

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US Patent:
20020076417, Jun 20, 2002
Filed:
Aug 9, 2001
Appl. No.:
09/927767
Inventors:
Michael Mahan - Santa Barbara CA, US
Douglas Heithoff - Goleta CA, US
David Low - Goleta CA, US
Robert Sinsheimer - Santa Barbara CA, US
International Classification:
A61K039/02
C12N001/21
US Classification:
424/200100, 435/252300, 435/252330, 435/252350
Abstract:
The present invention is directed towards an attenuated strain of pathogenic bacteria (e.g. Haemophilus, and/or Salmonella) having non-reverting genetic mutations relative to the wild-type organism which alter activity of DNA adenine methylase (Dam). The invention further includes compositions comprised of the attenuated bacteria and methods using these compositions to elicit an immune response to produce highly specific antibodies. The invention also provides methods for preparing vaccines as well as screening methods to identify agents which may have anti-bacterial activity.

Reducing Bacterial Virulence

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US Patent:
20020077272, Jun 20, 2002
Filed:
Aug 9, 2001
Appl. No.:
09/927885
Inventors:
Michael Mahan - Santa Barbara CA, US
Douglas Heithoff - Goleta CA, US
David Low - Goleta CA, US
Robert Sinsheimer - Santa Barbra CA, US
International Classification:
A61K031/00
A61K031/52
US Classification:
514/001000, 514/263400
Abstract:
The virulence of bacterial strains and in particular pathogenic bacteria which infect human is reduced by an agent which alters the bacteria's native level or activity of DNA methyltransferase (Dam). The agent causes an alteration in the bacteria's native level of methylation of adenine in a GATC tetranucleotide which inhibits virulence of the bacteria. Thus, compounds and formulations thereof which reduce bacterial virulence inhibit proliferation of bacteria and are useful in treating bacterial infections, particularly in humans.

Bacteria With Altered Dna Adenine Methylase (Dam) Activity And Heterologous Epitope

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US Patent:
20020081317, Jun 27, 2002
Filed:
Aug 9, 2001
Appl. No.:
09/927788
Inventors:
Michael Mahan - Santa Barbara CA, US
Douglas Heithoff - Goleta CA, US
David Low - Goleta CA, US
Robert Sinsheimer - Santa Barbara CA, US
International Classification:
A61K039/02
C12N001/21
C12N015/74
US Classification:
424/200100, 435/252300, 435/320100
Abstract:
Immunogenic compositions are disclosed which are comprised of bacteria which are pathogenic in their native state but which are rendered non-pathogenic in a manner which alters the native level or activity of DNA adenine methylase. The genome is also artificially engineered to express a heterologous antigen such as an immunogenic antigen of a virus, protozoa, parasite or fungi.

Producing Antibodies With Attenuated Bacteria With Altered Dna Adenine Methylase Activity

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US Patent:
20020086032, Jul 4, 2002
Filed:
Aug 9, 2001
Appl. No.:
09/927896
Inventors:
Michael Mahan - Santa Barbara CA, US
Douglas Heithoff - Goleta CA, US
David Low - Goleta CA, US
Robert Sinsheimer - Santa Barbara CA, US
International Classification:
A61K039/02
C12N001/21
US Classification:
424/200100, 435/252300
Abstract:
The present invention is directed towards methods of producing antibodies using an attenuated strain of pathogenic bacteria (e.g. Haemophilus, , and/or Salmonella) having non-reverting genetic mutations relative to the wild-type organism which alter activity of DNA adenine methylase (Dam). The invention further includes compositions comprised of the attenuated bacteria and methods using these compositions to elicit an immune response and immunize a subject with highly specific antibodies. The invention also provides methods producing antibodies to heterologous antigens which the attenuated bacteria are engineered to produce.

Method And Probes For The Identification Of Microbial Genes Specifically Induced During Host Infection

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US Patent:
6365401, Apr 2, 2002
Filed:
May 17, 1996
Appl. No.:
08/651155
Inventors:
Michael J. Mahan - Santa Barbara CA
Christopher P. Conner - Santa Barbara CA
Douglas M. Heithoff - Goleta CA
Assignee:
The Regents of the University of California - Oalkand CA
International Classification:
C12N 1931
US Classification:
4353201, 536 231, 536 237
Abstract:
The present invention relates to a class of microbial coding sequences the transcription or cotranscription of which is specifically induced during microbial infection of a host. These particular coding sequences or defined regions thereof may be used as probes to identify and isolate microbial virulence genes. The products of these virulence genes will provide potential targets for the development of vaccines or antimicrobial agents.
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Douglas M Heithoff from Santa Barbara, CA, age ~56 Get Report