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Dorota A Bulik

from Melrose, MA
Age ~60
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Also known as:
Dorota Bulk
Phone and address:
264 W Emerson St, Melrose, MA 02176
Connected to:
Cynthia M Bulik, 64Jeanette Bulin, 85Nancy L Bulin, 71Eric J Bulington, 50Sandra K Bulington, 55Wayne F Bulino, 56Harold R Bulitt, 103Jennifer A Buljan, 43Jill R Buljubasic, 40Cheryl A Bulka, 67

Dorota Bulik Phones & Addresses

  • 264 W Emerson St, Melrose, MA 02176
  • Malden, MA
  • Winchester, MA
  • 88 Paul Gore St, Jamaica Plain, MA 02130
  • Boston, MA
  • 74 Governor Winthrop Rd, Somerville, MA 02145
  • Cambridge, MA
  • Milford, MA
  • Lakewood, OH
  • 79 Wyoming Ave, Malden, MA 02148

Publications

Us Patents

Characterization Of -Glycans Using Exoglycosidases

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US Patent:
8361705, Jan 29, 2013
Filed:
Apr 15, 2008
Appl. No.:
12/595925
Inventors:
Ian Christopher Parsons - Belmont MA, US
Dorota A. Bulik - Malden MA, US
Carlos J. Bosques - Arlington MA, US
Brian Edward Collins - Arlington MA, US
Assignee:
Momenta Pharmaceuticals, Inc. - Cambridge MA
International Classification:
C12Q 1/00
US Classification:
435 4, 435 14, 435183, 435195
Abstract:
The present disclosure provides methods for analyzing structure and/or composition of N-glycans. Such methods often involve digestion of N-glycans with multiple exoglycosidases. In some embodiments, N-glycans are digested with multiple exoglycosidases simultaneously. In some embodiments, N-glycans are digested with multiple exoglycosidases sequentially. In some embodiments, methods in accordance with the present disclosure involve comparison of cleavage products of N-glycans that have been digested with multiple exoglycosidases simultaneously to N-glycans that have been digested with multiple exoglycosidases sequentially.

Defined Glycoprotein Products And Related Methods

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US Patent:
20100113294, May 6, 2010
Filed:
Apr 15, 2008
Appl. No.:
12/596171
Inventors:
Ganesh Venkataraman - Bedford MA, US
Brian Edward Collins - Somerville MA, US
Carlos J. Bosques - Cambridge MA, US
Dorota A. Bulik - Malden MA, US
Ian Christopher Parsons - Belmont MA, US
Zachary Shriver - Cambridge MA, US
Rajeev Chillakuru - Cambridge MA, US
Assignee:
MOMENTA PHARMACEUTICALS, INC. - Cambridge MA
International Classification:
C40B 30/02
C40B 40/10
US Classification:
506 8, 506 18
Abstract:
The invention provides methods, databases and systems for making glycoprotein products having defined properties.

Proteolytic Release Of Glycans

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US Patent:
20100151499, Jun 17, 2010
Filed:
Apr 15, 2008
Appl. No.:
12/595946
Inventors:
Brian Edward Collins - Arlington VA, US
Dorota A. Bulik - Winchester MA, US
Carlos J. Bosques - Arlington MA, US
Ian Christopher Parsons - Belmont MS, US
Assignee:
Momenta Pharmaceuticals, Inc. - Cambridge MA
International Classification:
G01N 33/567
C12P 21/00
US Classification:
435 721, 435 681
Abstract:
The present disclosure provides strategies for analyzing protein-linked glycans, and particularly for analyzing glycans on cell surface glycoproteins.

Methods Related To Cell Surface Glycosylation

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US Patent:
20100196940, Aug 5, 2010
Filed:
Apr 15, 2008
Appl. No.:
12/595902
Inventors:
Brian Edward Collins - Arlington MA, US
Carlos J. Bosques - Arlington MA, US
Xiangping Zhu - North Grafton MA, US
Dorota A. Bulik - Winchester MA, US
Ian Christopher Parsons - Belmont MA, US
Zachary Shriver - Cambridge MA, US
Rajeev Chillakuru - Cambridge MA, US
Ganesh Venkataraman - Bedford MA, US
Assignee:
MOMENTA PHARMACEUTICALS, INC. - Cambridge MA
International Classification:
C12Q 1/02
C12Q 1/37
US Classification:
435 23, 435 29
Abstract:
The present disclosure provides methods for assessing the glycosylation of a target glycoprotein produced by a cell through analysis of cell-surface glycans on the cell. The present disclosure therefore teaches that glycosylation of cell surface proteins can serve as a proxy for glycosylation of other proteins.

Methods Of Modulating Fucosylation Of Glycoproteins

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US Patent:
20120277165, Nov 1, 2012
Filed:
Jun 4, 2010
Appl. No.:
13/375577
Inventors:
Brian E. Collins - Arlington MA, US
Dorota A. Bulik - Malden MA, US
Kevin Millea - Saugus MA, US
International Classification:
C12P 21/00
C12N 5/071
C12M 3/00
A61K 38/14
G01N 27/62
G01N 30/02
G01N 24/08
C12Q 3/00
C12P 21/08
C12Q 1/02
US Classification:
514 209, 435 703, 435325, 4352891, 435 29, 435 3
Abstract:
The present invention provides methods and materials useful for monitoring and regulating the glycosylation of glycoproteins that are recombinantly produced from cells. In particular, methods are provided for monitoring and regulating levels of cellular indicators which affect the level of fucosylation produced by cells.

Production Of Glycoproteins

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US Patent:
20120329709, Dec 27, 2012
Filed:
May 25, 2010
Appl. No.:
13/322049
Inventors:
Brian Edward Collins - Arlington MA, US
Tiffany Guo - Lagrange OH, US
Kevin Millea - Saugus MA, US
Dorota A. Bulik - Malden MA, US
International Classification:
C12P 21/00
A61K 38/38
A61K 38/28
A61K 38/27
A61K 38/26
A61K 38/37
C07K 14/57
C07K 14/76
C07K 14/755
C07K 16/40
C07K 14/61
C07K 16/24
C07K 14/62
G01N 27/62
C12Q 1/68
C12N 1/21
C12N 1/19
C12N 5/10
C12N 1/15
C12N 9/50
C12N 9/24
C12N 9/02
C12N 9/40
C12N 9/82
C12N 9/22
A61K 38/02
US Classification:
514 64, 514 209, 514 152, 514 114, 514 113, 514 117, 514 11, 514 141, 530351, 530362, 530383, 5303873, 530397, 53038815, 530304, 435 691, 435 18, 435325, 435 61, 43525233, 43525423, 4352542, 43525421, 435348, 435419, 435412, 435414, 43525411, 435364, 435369, 435358, 435354, 435367, 435353, 435366, 435370, 435350, 435372, 4353723, 435219, 435200, 435189, 435208, 435229, 435199
Abstract:
The present invention provides methods and materials by which glycosylation of glycoproteins can be regulated. Methods include the monitoring and regulation of parameters such that a glycoprotein having a desired product quality is obtained.

Characterization Of N-Glycans Using Exoglycosidases

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US Patent:
20130184180, Jul 18, 2013
Filed:
Dec 19, 2012
Appl. No.:
13/720192
Inventors:
Dorota A. Bulik - Winchester MA, US
Carlos J. Bosques - Arlington MA, US
Brian Edward Collins - Arlington MA, US
Assignee:
MOMENTA PHARMACEUTICALS, INC. - Cambridge MA
International Classification:
C12Q 1/34
US Classification:
506 12, 435 18
Abstract:
The present disclosure provides methods for analyzing structure and/or composition of N-glycans. Such methods often involve digestion of N-glycans with multiple exoglycosidases. In some embodiments, N-glycans are digested with multiple exoglycosidases simultaneously. In some embodiments, N-glycans are digested with multiple exoglycosidases sequentially. In some embodiments, methods in accordance with the present disclosure involve comparison of cleavage products of N-glycans that have been digested with multiple exoglycosidases simultaneously to N-glycans that have been digested with multiple exoglycosidases sequentially.

High Mannose Glycans

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US Patent:
20130231255, Sep 5, 2013
Filed:
Apr 7, 2011
Appl. No.:
13/637974
Inventors:
Brian Edward Collins - Arlington MA, US
Jay Duffner - Shirley MA, US
Carlos J. Bosques - Arlington MA, US
Dorota A. Bulik - Malden MA, US
James Myette - Waltham MA, US
James Meador - Framingham MA, US
Assignee:
MOMENTA PHARMACEUTICALS, INC. - Cambridge MA
International Classification:
G01N 33/50
C12P 21/00
US Classification:
506 6, 435 691
Abstract:
Methods and compositions related to high mannose glycans are described.
Control profile
Dorota A Bulik from Melrose, MA, age ~60 Get Report