Inventors:
Carlos F. Barbas - Del Mar CA
Doron Shabat - San Diego CA
Christoph Rader - San Diego CA
Benjamin List - San Diego CA
Richard A. Lerner - La Jolla CA
International Classification:
C07H 1524
C07D27730
Abstract:
The present invention provides a compound that includes an active therapeutic agent attached to a blocking moiety that is sensitive to the catalytic action of molecules having retro-aldol and retro-Michael catalytic activity, methods for making such compounds and methods of converting such compounds to active therapeutic agents using molecules having aldolase activity.