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Dionisios Rentzeperis

from Middletown, MD
Age ~57
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Also known as:
Dennis Rentzeperis, Rentzeperis Dionisi, Dionisios S
Phone and address:
203 Broad St, Middletown, MD 21769
(240) 490-7477
Related to:
George E Klein, 94Harilaos RentzeperisUmberto Mastrantoni, 89Anna Mastrantoni, 61Ann M Barbagallo, 69Frederike Rentzeperis
Connected to:
Alex J Rentziperis, 69Brian K Rentzsch, 53Delgado L Renulfo, 54Allison Renville, 40Andrea R Renville, 31Kevin A Renville, 64Kim E Renvoize, 66Karl Renwanz, 73Ben Renwick, 46David Renwick, 58

Dionisios Rentzeperis Phones & Addresses

  • 203 Broad St, Middletown, MD 21769 (240) 490-7477
  • 2026 Parsons Blvd, Whitestone, NY 11357 (718) 961-3383
  • Corona, NY
  • 406 Carpenters Cove Ln, Downingtown, PA 19335
  • West Chester, PA
  • Boston, MA
  • Chester, PA

Work

Company: Johnson & johnson Mar 2003 Position: Principal scientist, discovery project leader

Education

Degree: Doctorates, Doctor of Philosophy School / High School: New York University 1989 to 1994 Specialities: Chemistry

Skills

In Vitro • Biomarkers • Drug Discovery • Pharmacology

Industries

Pharmaceuticals

Resumes

Resumes

Dionisios Rentzeperis Photo 1

Principal Scientist, Discovery Project Leader

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Location:
1 Greenbrook Rd, Middlesex, NJ 08846
Industry:
Pharmaceuticals
Work:
Johnson & Johnson
Principal Scientist, Discovery Project Leader
3 Dimensional Pharmaceuticals 1988 - 2003
Research Fellow
Education:
New York University 1989 - 1994
Doctorates, Doctor of Philosophy, Chemistry Massachusetts Institute of Technology
Skills:
In Vitro
Biomarkers
Drug Discovery
Pharmacology

Publications

Us Patents

Substituted Phenoxy N-Alkylated Thiazolidinediones As Estrogen Related Receptor-Α Modulators

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US Patent:
8119669, Feb 21, 2012
Filed:
Mar 6, 2008
Appl. No.:
12/043291
Inventors:
Michael Gaul - Yardley PA, US
Lily Lee Searle - Waltham MA, US
Dionisios Rentzeperis - Downingtown PA, US
Assignee:
Janssen Pharmaceutica N.V. - Beerse
International Classification:
A61K 31/425
A61K 31/42
C07D 277/00
C07D 263/00
US Classification:
514369, 514376, 548183, 548227
Abstract:
The present invention relates to compounds of Formula (I),.

Co-Crystallization Of Err-Α With A Ligand That Forms A Reversible Covalent Bond

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US Patent:
8187871, May 29, 2012
Filed:
Aug 4, 2010
Appl. No.:
12/850076
Inventors:
Dionisios Rentzeperis - Downingtown PA, US
Marta Cristina Abad - Downingtown PA, US
Ludmila A. Barnakova - Downingtown PA, US
Frank A. Lewandowski - Washington Crossing PA, US
Cynthia M. Milligan - Rutledge PA, US
Assignee:
Janssen Pharmaceutica N.V. - Beerse
International Classification:
C12N 15/00
C12N 5/00
C07K 14/00
G01N 31/00
US Classification:
4353201, 435325, 530350, 436 4
Abstract:
The crystal structure of the ligand binding domain of ERR-α in complex with a ligand that forms a reversible thioether bond to Cys325 of ERR-α, methods to measure dissociation rates for ligands that form reversible covalent bonds, and methods to design ligands that form reversible covalent bonds for use as modulators of ERR-α activity are disclosed. The crystal structure and methods provide a novel molecular mechanism for modulation of the activity of ERR-α and provide the basis for rational drug design to obtain potent specific ligands for use as modulators of the activity of this new drug target.

Co-Crystallization Of Err-Α With A Ligand That Forms A Reversible Covalent Bond

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US Patent:
8455244, Jun 4, 2013
Filed:
Apr 30, 2012
Appl. No.:
13/459672
Inventors:
Dionisios Rentzeperis - Downingtown PA, US
Marta Cristina Abad - Downingtown PA, US
Ludmila A. Barnakova - Downingtown PA, US
Frank A. Lewandowski - Washington Crossing PA, US
Cynthia M. Milligan - Rutledge PA, US
Assignee:
Janssen Pharmaceutica N.V. - Beerse
International Classification:
C12N 15/00
C12N 5/00
C07K 14/00
G01N 31/00
US Classification:
4353201, 435325, 530350, 436 4
Abstract:
The crystal structure of the ligand binding domain of ERR-α in complex with a ligand that forms a reversible thioether bond to Cys325 of ERR-α, methods to measure dissociation rates for ligands that form reversible covalent bonds, and methods to design ligands that form reversible covalent bonds for use as modulators of ERR-α activity are disclosed. The crystal structure and methods provide a novel molecular mechanism for modulation of the activity of ERR-α and provide the basis for rational drug design to obtain potent specific ligands for use as modulators of the activity of this new drug target.

Substituted Phenoxy Aminothiazolones As Estrogen Related Receptor-Α Modulators

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US Patent:
8580832, Nov 12, 2013
Filed:
Mar 6, 2008
Appl. No.:
12/043311
Inventors:
Michael Gaul - Yardley PA, US
Alexander Kim - Levittown PA, US
Lily Lee Searle - Waltham MA, US
Dionisios Rentzeperis - Downingtown PA, US
Gilles C. Bignan - Brigewater NJ, US
Assignee:
Janssen Pharmaceutica N.V.
International Classification:
A61K 31/425
C07D 277/08
C07D 277/12
US Classification:
514369, 514370, 548184
Abstract:
The present invention relates to compounds of Formula (I),.

Use Of Estrogen Related Receptor-Modulating Aryl Ethers

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US Patent:
20060014812, Jan 19, 2006
Filed:
Jul 8, 2005
Appl. No.:
11/177716
Inventors:
Mark Player - Phoenixville PA, US
Richard Pottorf - Belle Mead NJ, US
Dionisios Rentzeperis - Downingtown PA, US
Dibyendu De - Suwanee GA, US
International Classification:
A61K 31/426
A61K 31/42
A61K 31/415
A61K 31/198
A61K 31/277
US Classification:
514369000, 514378000, 514649000, 514621000, 514521000, 514567000, 514406000
Abstract:
Therapeutic methods of using certain heterocyclic arylidene aryl ether compounds for treating diseases or disorders mediated through modulation of estrogen related receptor alpha are described.

Method For The Idenification Of Ligands

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US Patent:
20060024844, Feb 2, 2006
Filed:
Sep 20, 2002
Appl. No.:
10/522660
Inventors:
Dionisios Rentzeperis - Downingtown PA, US
Hossein Askari - Exton HA. PA, US
Barry Springer - Wilmington DE, US
Roger Bone - Bridgewater NJ, US
Francis Salemme - Yardley PA, US
International Classification:
G01N 33/543
G06F 19/00
G01N 33/48
G01N 33/50
US Classification:
436518000, 702019000
Abstract:
The present invention relates generally to a method of identifying ligands that modulate protein-protein interactions. More particularly, the present invention relates to methods of determining agonists or antagonists of a co-regulator dependent target molecule based on the ability to modify the stability of the target molecule.

Method For Determining The Regulation Of Xenobiotic Removal

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US Patent:
20060099643, May 11, 2006
Filed:
Jul 23, 2003
Appl. No.:
10/522396
Inventors:
Roger Bone - Bridgewater NJ, US
Dionisios Rentzeperis - Downingtown PA, US
International Classification:
G01N 33/53
G06F 19/00
US Classification:
435007100, 702019000
Abstract:
The present invention relates generally to a method for identifying ligands that affect xenobiotic removal based upon their ability to modify the stability of receptors that regulate cytochrome P450 expression and/or drug transport proteins.

Method For The Identification Of Ligands

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US Patent:
20060110732, May 25, 2006
Filed:
Jul 23, 2003
Appl. No.:
10/519757
Inventors:
Roger Bone - Bridgewater NJ, US
Dionisios Rentzeperis - Downingtown PA, US
Hossein Askari - West Chester PA, US
Barry Springer - Wilmington DE, US
International Classification:
C12Q 1/68
G01N 33/53
US Classification:
435006000, 435007100
Abstract:
The present invention relates generally to a method of identifying ligands that modulate protein-protein interactions. More particularly, the present invention relates to methods of determining agonists or antagonists of a co-regulator dependent target molecule based on the ability to modify the stability of the target molecule in a tissue-selective manner.
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Dionisios Rentzeperis from Middletown, MD, age ~57 Get Report