Gerard LeClerc - Grenoble, FR Didier Huber - Fort Worth TX Jacques Himber - Guebwiller, FR Guy Andermann - Strasbourg, FR
Assignee:
Laboratories Alcon S.A. - Kaysersberg
International Classification:
A61K 31415 C07D23322
US Classification:
514401
Abstract:
Antiglaucoma compounds having beta adrenoreceptor antagonist properties and alpha adrenoreceptor antagonist properties are described. The compounds comprise a beta blocker-derived moiety designed to provide beta antagonist properties and an imidazolidine moiety designed to provide alpha-antagonist properties. Methods of synthesizing the compounds are also described. The compounds are useful in the treatment of glaucoma due to their ability to lower elevated intraocular pressure.