- Chicago IL, US Zhengrong Yu - Carlsbad CA, US Mark K. Wedel - Temecula CA, US Diane Tribble - Asbury NJ, US
Assignee:
Kastle Therapeutics, LLC - Chicago IL
International Classification:
C12N 15/113
Abstract:
Methods for long-term lowering of lipid levels in human subjects and for the treatment of conditions associated with elevated LDL-cholesterol and elevated ApoB are provided.
- CARLSBAD CA, US Rosanne M. Crooke - Carlsbad CA, US Mark J. Graham - San Clemente CA, US Kristina M. Lemonidis - Oceanside CA, US Sanjay Bhanot - Carlsbad CA, US Diane Tribble - Asbury NJ, US Andrew T. Watt - San Diego CA, US
Assignee:
ISIS PHARMACEUTICALS, INC. - CARLSBAD CA
International Classification:
C12N 15/113
Abstract:
Disclosed herein are antisense compounds and methods for decreasing LDL-C in an individual having elevated LDL-C. Additionally disclosed are antisense compounds and methods for treating, preventing, or ameliorating hypercholesterolemia and/or atherosclerosis. Further disclosed are antisense compounds and methods for decreasing coronary heart disease risk. Such methods include administering to an individual in need of treatment an antisense compound targeted to a PCSK9 nucleic acid. The antisense compounds administered include gapmer antisense oligonucleotides.
- Carlsbad CA, US Rosanne M. Crooke - Carlsbad CA, US Mark J. Graham - San Clemente CA, US Kristina M. Lemonidis - Oceanside CA, US Sanjay Bhanot - Carlsbad CA, US Diane Tribble - Asbury NJ, US Andrew T. Watt - San Diego CA, US
Assignee:
ISIS PHARMACEUTICALS, INC. - Carlsbad CA
International Classification:
C12N 15/113
US Classification:
514 44 A, 536 245
Abstract:
Disclosed herein are antisense compounds and methods for decreasing LDL-C in an individual having elevated LDL-C. Additionally disclosed are antisense compounds and methods for treating, preventing, or ameliorating hypercholesterolemia and/or atherosclerosis. Further disclosed are antisense compounds and methods for decreasing coronary heart disease risk. Such methods include administering to an individual in need of treatment an antisense compound targeted to a PCSK9 nucleic acid. The antisense compounds administered include gapmer antisense oligonucleotides.