Diane L Kozwich

6649378, Nov 18, 2003

Nov 2, 2000

09/705043

Diane L. Kozwich - Englewood CO
John C. Gerdes - Denver CO

Xtrana, Inc. - Broomfield CO

C12P 1934

435 912, 435 6, 435 911, 4352872, 422 681, 422 69, 422 70, 536 231, 536 243, 536 2431, 536 2433

Self-contained devices are described that integrate nucleic acid extraction, specific target amplification and detection into a single device. This integration permits rapid and accurate nucleic acid sequence detection. The invention may be used, for example, in the screening for nucleic acid sequences which may be indicative of genetic defects or contagious diseases, as well as for monitoring efficacy in the treatment of contagious diseases.

8343486, Jan 1, 2013

Jan 22, 2009

12/358078

Stephen G. Carter - Andover MA, US
Zhen Zhu - Tewksbury MA, US
Kanu Patel - Londonderry NH, US
Diane L. Kozwich - Nottingham NH, US

BioChemics, Inc. - Danvers MA

A61K 38/43

424 941

A method for treating a patient suffering from a wound, ulcer, or inflammation includes providing a topical formulation comprising a carrier and a combination of active ingredients that includes at least one retinoid and at least one blood vessel dilator, and applying the topical formulation to the skin of the patient to cause healing, accelerated healing or prevention of the wound, ulcer or inflammation. Additional active ingredients may include a promoter of mitochondrial function or an antioxidant.

20070284250, Dec 13, 2007

Mar 13, 2007

11/685634

Gary Magnant - Topsfield MA, US
Michael Finney - San Francisco CA, US
Todd Barbera - Marblehead MA, US
William Bowers - Ipswich MA, US
Diane Kozwich - Nottingham NH, US
Samuel Seymour - Marblehead MA, US
Robert Nelson - Sioux Falls SD, US
T. Boles - Bedford MA, US

SAGE SCIENCE, INC. - Beverly MA

C07K 1/26
C07K 1/28
C25B 9/08

204459000, 204456000, 204461000, 204464000, 204606000, 204610000, 204614000, 073864910

Devices and methods are provided for more efficiently performing electrophoresis and electroblotting. A sandwich structure includes an electrophoresis gel affixed to a blotting membrane. A gel casting and/or running frame is used to hold the sandwich. A method and composition that allows separation of the gel and membrane after performing a combined electrophoresis and electroblotting operation so as to allow further operations to be performed individually upon the membrane, gel or both. A uniform electrophoretic field may be created by surrounding the sandwich structure using an insulating fluid; the insulating fluid is then swapped for a conducting fluid to allow application of an electroblotting field. An apparatus automatically manages fluid exchange and actuation of electrophoresis and electroblotting electrodes. A plurality of parallel cavities may be used to hold multiple gels or gel membrane sandwiches.

20100137443, Jun 3, 2010

Sep 10, 2009

12/557470

Stephen G. Carter - Andover MA, US
Zhen Zhu - Andover MA, US
Kanu Patel - Londonderry NH, US
Diane L. Kozwich - Nottingham NH, US

BIOCHEMICS, INC. - Danvers MA

A61K 31/192
A61P 29/00

514570

Set forth herein is a preparation of ibuprofen (2-(4-isobutylphenyl)propionic acid) in the free acid form that is suitable for topical administration. The topical ibuprofen formulation is prepared by dissolving the free acid form of ibuprofen, or preparing a homogeneous suspension of the free acid form of ibuprofen, in the presence of a pharmaceutically acceptable solvent so as to produce a topical drug formulation compatible with the penetration of 2-(4-isobutylphenyl) propionic acid through the skin tissue. Topical formulations of ibuprofen can be based on a pharmaceutically acceptable solvent such as, e.g., a pyrrolidone solvent or dimethylacetamide.

20100145256, Jun 10, 2010

Dec 4, 2009

12/631698

Stephen G. Carter - Andover MA, US
Zhen Zhu - Andover MA, US
Kanu Patel - Londonderry NH, US
Diane L. Kozwich - Nottingham NH, US
Laura Stephens - Danvers MA, US
John J. Masiz - Topsfield MA, US
David H. Donabedian - Pawtucket RI, US

BioChemics, Inc. - Danvers MA

A61M 37/00
A61K 8/18
A61Q 19/00

604 20, 424 62

Methods and formulations for removing a tattoo by using a cell disrupter in combination with a vasodilator, and optionally one or more of an osmotic modifying agent, a chelation agent, and an occlusive modifying agent. Embodiments optionally further include using one or more of an antibiotic, anesthetic, penetration enhancer, excipient, carrier and vehicle.

20120329875, Dec 27, 2012

Sep 5, 2012

13/604040

Stephen G. Carter - Andover MA, US
Zhen Zhu - Andover MA, US
Kanu Patel - Londonderry NH, US
Diane L. Kozwich - Nottingham NH, US

BioChemics, Inc. - Danvers MA

A61K 31/192
A61P 29/00

514570

Set forth herein is a preparation of ibuprofen (2-(4-isobutylphenyl) propionic acid) in the free acid form that is suitable for topical administration. The topical ibuprofen formulation is prepared by dissolving the free acid form of ibuprofen, or preparing a homogeneous suspension of the free acid form of ibuprofen, in the presence of a pharmaceutically acceptable solvent so as to produce a topical drug formulation compatible with the penetration of 2-(4-isobutylphenyl) propionic acid through the skin tissue. Topical formulations of ibuprofen can be based on a pharmaceutically acceptable solvent such as, e.g., a pyrrolidone solvent or dimethylacetamide.

20130273019, Oct 17, 2013

Dec 4, 2012

13/693346

Zhen Zhu - Andover MA, US
Kanu Patel - Londonderry NH, US
Diane L. Kozwich - Nottingham NH, US

A61K 31/07
A61K 31/122
A61K 31/203
A61K 31/455
A61K 31/198

424 941, 514356, 514565, 514559, 514690

A method for treating a patient suffering from a wound, ulcer, or inflammation includes providing a topical formulation comprising a carrier and a combination of active ingredients that includes at least one retinoid and at least one blood vessel dilator, and applying the topical formulation to the skin of the patient to cause healing, accelerated healing or prevention of the wound, ulcer or inflammation. Additional active ingredients may include a promoter of mitochondrial function or an antioxidant.

61534250, Nov 28, 2000

Aug 27, 1998

9/141401

Diane L. Kozwich - Englewood CO
John C. Gerdes - Denver CO

Xtrana, Inc. - Denver CO

C12M 124
C12M 140

4352872

A self-contained device is described that integrates nucleic acid extraction, specific target amplification and detection into a single device. This integration permits rapid and accurate nucleic acid sequence detection. The invention may be used, for example, in the screening for nucleic acid sequences which may be indicative of genetic defects or contagious diseases, as well as for monitoring efficacy in the treatment of contagious diseases.