Inventors:
Desiree Tsao - Belmont MA, US
Jean-Baptiste Telliez - Waltham MA, US
Thomas McDonagh - Acton MA, US
Lih-Ling Lin - Concord MA, US
Sang Hsu - Lexington MA, US
A. Malakian - Boxborough MA, US
International Classification:
A61K038/19
C07K014/52
Abstract:
The present invention relates to the three dimensional solution structure of the N-terminal domain of TNFR-1 associated death domain protein (“N-TRADD”), as well as the identification and characterization of a C-TRAF2 binding active site of N-TRADD. Also provided for by the present invention are methods of utilizing the three dimensional structures for the design and selection of potent and selective inhibitors of TNF signaling pathways.
