Jill Edie Hochlowski - Green Oaks IL Thomas J. Sowin - Wadsworth IL Daniel W. Norbeck - Crystal Lake IL Warren S. Wade - Grayslake IL David N. Whittern - Green Oaks IL
Assignee:
Abbott Laboratories - Abbott Park IL
International Classification:
C12Q 100 G01N 33566 G01N 33543
US Classification:
435 4
Abstract:
The present invention relates to coding combinatorial chemical libraries synthesized on a plurality of solid supports by attaching "tags" that comprise fluorine containing compounds in combinations and/or ratios. The tags can be decoded while attached to the solid support by fluorine nuclear magnetic resonance spectroscopy to follow the reaction history of individual beads, and to determine the particular member of the library that is attached on the bead.