Inventors:
Yiwen Li - Jersey City NJ, US
Dan Lu - Montvale NJ, US
James Robert Tonra - Skillman NJ, US
David Surguladze - Chatham NJ, US
International Classification:
A61K 39/395
C07K 16/18
C07H 21/04
C12N 15/63
C12N 5/10
C12P 21/06
US Classification:
4241391, 5303879, 536 2353, 4353201, 435325, 435 696
Abstract:
The present invention provides fully human antibodies that specifically bind to human FLT3 within extracellular domains 4 or 5 with high affinity. The invention further provides methods of treating leukemia by administering an effective amount of an antibody either alone or in combination with an anti-cancer agent or treatment including methotrexate.