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David Allan Boothman

from Dallas, TX
Age ~66
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Also known as:
David A Boothman, David Allan Dr Boothman, Ph D Boothman, Dave A Boothman, David A Bootman, Davida Boothman
Phone and address:
6834 Mimosa Ln, Dallas, TX 75230
(214) 504-0128
Related to:
D Bootman, 66D Bootman
Connected to:
Casey C Boothman, 34Dale A Boothman, 58Laura P Boothman, 41Tina M Boothman, 57Tyler Boothman, 30Lisa Boothroyd, 41Sarah M Boothroyd, 30Sophie Boothroyd, 65Frank Booths, 43Desmond O Bootle, 55

David Boothman Phones & Addresses

  • 6834 Mimosa Ln, Dallas, TX 75230 (214) 504-0128 (214) 774-9481
  • 1704 Canyon Creek Dr, McKinney, TX 75070 (214) 504-0128
  • Mc Kinney, TX
  • 8613 Deep Cove Dr, Northfield, OH 44067 (330) 468-2682
  • Madison, WI
  • 10900 Euclid Ave, Cleveland, OH 44106
  • Ann Arbor, MI
  • Allston, MA
  • 8613 Deep Cove Dr, Northfield, OH 44067 (330) 283-0950

Work

Position: Administrative Support Occupations, Including Clerical Occupations

Education

Degree: Bachelor's degree or higher

Emails

t***[email protected]

Resumes

Resumes

David Boothman Photo 1

Professor

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Location:
Dallas, TX
Industry:
Research
Work:
Indiana University School of Medicine
Professor
Ut Medical Center
Professor and Associate Director For Translational Research
Ut Southwestern Medical Center
Professor and Assoc Director Cancer Center
Case Western Reserve University 1998 - 2005
Associate Director For Basic Science
University of Wiscoonsin-Madison 1992 - 1998
Associate Professor, Vice Chairman Radiation Oncology
Education:
Harvard Medical School 1986 - 1989
University of Miami, Miller School of Medicine 1981 - 1986
Doctorates, Doctor of Philosophy, Biochemistry, Microbiology, Philosophy University of Michigan 1976 - 1981
Bachelors, Bachelor of Science, Microbiology, Immunology
Skills:
Cancer
Science
Translational Research
Molecular Biology
Cell Biology
Cell Culture
Radiation Therapy
Pharmacology
Biochemistry
Immunohistochemistry
Flow Cytometry
Life Sciences
Western Blotting
Immunology
Cell
Biotechnology
Animal Models
Genetics
Protein Purification
Confocal Microscopy
Medicine
Genomics
Protein Chemistry
Tissue Culture
Protein Expression
Lifesciences
Qpcr
Elisa
Neuroscience
Interests:
Economic Empowerment
Education
Environment
Science and Technology
Human Rights
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David Boothman

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David Boothman

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Publications

Us Patents

Lapachone Delivery Systems, Compositions And Uses Related Thereto

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US Patent:
6890950, May 10, 2005
Filed:
Apr 23, 2003
Appl. No.:
10/422053
Inventors:
David Boothman - Sagamore Hills OH, US
Jinming Gao - Pepper Pike OH, US
Norased Nasongkla - Cleveland OH, US
John Pink - Shaker Heights OH, US
Assignee:
Case Western Reserve University - Cleveland OH
International Classification:
A61K031/352
C07D311/92
US Classification:
514454, 514455, 549389
Abstract:
In part, the present invention is directed to a system comprising a lapachone or a prodrug thereof and a polymer, such as a biocompatible and optionally biodegradable polymer, methods for treatment using the subject polymer compositions, and methods of making and using the same. In another part, the present invention includes inclusion complexes of a lapachone or a prodrug thereof and a cyclodextrin, preferably a β-cyclodextrin, such as hydroxypropyl β-cyclodextrin, e. g. , to improve the solubility of the lapachone or prodrug thereof.

Lapachone Delivery Systems, Compositions And Uses Related Thereto

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US Patent:
20050175668, Aug 11, 2005
Filed:
Mar 4, 2005
Appl. No.:
11/073331
Inventors:
David Boothman - Sagamore Hills OH, US
Jinming Gao - Pepper Pike OH, US
Norased Nasongkla - Cleveland OH, US
John Pink - Shaker Heights OH, US
Assignee:
Case Western Reserve University - Cleveland OH
International Classification:
A61K031/724
A61K031/353
A61N005/00
US Classification:
424423000, 514453000, 514058000, 600001000
Abstract:
In part, the present invention is directed to a system comprising a lapachone or a prodrug thereof and a polymer, such as a biocompatible and optionally biodegradable polymer, methods for treatment using the subject polymer compositions, and methods of making and using the same. In another part, the present invention includes inclusion complexes of a lapachone or a prodrug thereof and a cyclodextrin, preferably a β-cyclodextrin, such as hydroxypropyl β-cyclodextrin, e.g., to improve the solubility of the lapachone or prodrug thereof.

Ph-Sensitive Compositions For Delivery Of Beta Lapachone And Methods Of Use

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US Patent:
20130331426, Dec 12, 2013
Filed:
Aug 11, 2011
Appl. No.:
13/825524
Inventors:
Jinming GAO - Plano TX, US
David Boothman - Dallas TX, US
Yinjian Zhou - Beijing, CN
Erik Bey - Morgantown WV, US
Assignee:
The Board of Regents of the University of Texas System - Austin TX
International Classification:
A61K 47/48
US Classification:
514422, 548525
Abstract:
Disclosed herein are compounds comprising a polymer conjugated with a pH-sensitive prodrug of beta-lapachone, wherein the compound is capable of forming a micelle, and wherein the pH-sensitive prodrug comprises a pH-sensitive linker selected from the group consisting of: an aryl imine and an aliphatic imine. Also provided are micelles comprised of such polymer-prodrug conjugates. Further provided are methods for treating cancer with the micelles.

Novel Block Copolymer And Micelle Compositions And Methods Of Use Thereof

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US Patent:
20140023590, Jan 23, 2014
Filed:
Aug 11, 2011
Appl. No.:
13/825518
Inventors:
Jinming Gao - Plano TX, US
David Boothman - Dallas TX, US
Kejin Zhou - Dallas TX, US
Xiaonan Huang - Beijing, CN
Yiguang Wang - Dallas TX, US
Assignee:
The Board of Regents of the University of Texas System - Austin TX
International Classification:
A61K 49/00
A61K 31/704
A61K 31/337
A61K 9/50
US Classification:
424 96, 525421, 424497, 514 34, 514449, 424 91
Abstract:
Provided herein are block copolymers comprising a hydrophilic polymer segment and a hydrophobic polymer segment, wherein the hydrophilic polymer segment comprises a polymer selected from the group consisting of: poly(ethylene oxide) (PEO), poly(methacrylate phosphatidyl choline) (MPC), and polyvinylpyrrolidone (PVP), wherein the hydrophobic polymer segment comprises wherein R′ is —H or —CH, wherein R is —NRR, wherein Rand Rare alkyl groups, wherein Rand Rare the same or different, wherein Rand Rtogether have from 5 to 16 carbons, wherein Rand Rmay optionally join to form a ring, wherein n is 1 to about 10, and wherein x is about 20 to about 200 in total. Also provided are pH-sensitive micelle compositions for therapeutic and diagnostic applications.

Synthesis And Use Of .Beta.-Lapachone Analogs

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US Patent:
57636257, Jun 9, 1998
Filed:
Apr 25, 1995
Appl. No.:
8/428574
Inventors:
David A. Boothman - Madison WI
Benjamin J. Frydman - Madison WI
Donald T. Witiak - Madison WI
Assignee:
Wisconsin Alumni Research Foundation - Madison WI
International Classification:
C07D31180
US Classification:
549390
Abstract:
3-Substituted-. beta. -lapachone analogs and their use either alone or to augment chemotherapy or radiotherapy to induce programmed neoplastic cell death without exhibiting toxicity to surrounding normal cells are disclosed. In particular, 3-allyl-. beta. -lapachones, 3-alkyl-. beta. -lapachones and 3-halo-. beta. -lapachones were found to be Topoisomerase (Topo I) inhibitors. When these analogs are used alone there is a reversible single-strand break in the DNA of neoplastic cells causing apoptosis and cell death in some cells. However, when these analogs are combined with chemotherapy or X-irradiation, an irreversible Topo I-mediated break is achieved. A new and more efficient chemical synthesis of the compounds is also disclosed.

Novel Block Copolymer And Micelle Compositions And Methods Of Use Thereof

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US Patent:
20180291134, Oct 11, 2018
Filed:
Jun 13, 2018
Appl. No.:
16/006885
Inventors:
- Austin TX, US
David BOOTHMAN - Dallas TX, US
Kejin ZHOU - Dallas TX, US
Xiaonan HUANG - Beijing, CN
Yiguang WANG - Dallas TX, US
Assignee:
The Board of Regents of the University of Texas System - Austin TX
International Classification:
C08F 293/00
A61K 31/704
A61K 47/62
A61K 47/68
C07D 311/92
A61K 49/00
A61K 47/58
A61K 31/352
A61K 31/337
A61K 9/50
A61K 9/127
A61K 9/107
C08F 220/34
Abstract:
Provided herein are block copolymers comprising a hydrophilic polymer segment and a hydrophobic polymer segment, wherein the hydrophilic polymer segment comprises a polymer selected from the group consisting of: poly(ethylene oxide) (PEO), poly(methacrylate phosphatidyl choline) (MPC), and polyvinylpyrrolidone (PVP), wherein the hydrophobic polymer segment compriseswherein R′ is —H or —CH, wherein R is —NRR, wherein Rand Rare alkyl groups, wherein Rand Rare the same or different, wherein Rand Rtogether have from 5 to 16 carbons, wherein Rand Rmay optionally join to form a ring, wherein n is 1 to about 10, and wherein x is about 20 to about 200 in total. Also provided are pH-sensitive micelle compositions for therapeutic and diagnostic applications.

Novel Block Copolymer And Micelle Compositions And Methods Of Use Thereof

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US Patent:
20170320993, Nov 9, 2017
Filed:
Jul 27, 2017
Appl. No.:
15/662184
Inventors:
- Austin TX, US
David BOOTHMAN - Dallas TX, US
Kejin ZHOU - Dallas TX, US
Xiaonan HUANG - Beijing, CN
Yiguang WANG - Dallas TX, US
Assignee:
The Board of Regents of the University of Texas System - Austin TX
International Classification:
C08F 293/00
A61K 47/68
A61K 47/68
C07D 311/92
A61K 49/00
A61K 49/00
A61K 49/00
A61K 49/00
A61K 47/58
A61K 31/352
A61K 31/337
A61K 9/50
A61K 9/127
A61K 9/107
A61K 31/704
A61K 49/00
C08F 220/34
Abstract:
Provided herein are block copolymers comprising a hydrophilic polymer segment and a hydrophobic polymer segment, wherein the hydrophilic polymer segment comprises a polymer selected from the group consisting of: poly(ethylene oxide) (PEO), poly(methacrylate phosphatidyl choline) (MPC), and polyvinylpyrrolidone (PVP), wherein the hydrophobic polymer segment compriseswherein R′ is —H or —CH, wherein R is —NRR, wherein Rand Rare alkyl groups, wherein Rand Rare the same or different, wherein Rand Rtogether have from 5 to 16 carbons, wherein Rand Rmay optionally join to form a ring, wherein n is 1 to about 10, and wherein x is about 20 to about 200 in total. Also provided are pH-sensitive micelle compositions for therapeutic and diagnostic applications.

Novel Block Copolymer And Micelle Compositions And Methods Of Use Thereof

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US Patent:
20160220706, Aug 4, 2016
Filed:
Mar 17, 2016
Appl. No.:
15/072522
Inventors:
- Austin TX, US
David BOOTHMAN - Dallas TX, US
Kejin ZHOU - Dallas TX, US
Xiaonan HUANG - Beijing, CN
Yiguang WANG - Dallas TX, US
Assignee:
THE BOARD OF REGENTS OF THE UNIVERSITY OF TEXAS SYSTEM - Austin TX
International Classification:
A61K 49/00
A61K 47/48
A61K 31/337
A61K 31/704
C08F 293/00
A61K 9/107
Abstract:
Provided herein are block copolymers comprising a hydrophilic polymer segment and a hydrophobic polymer segment, wherein the hydrophilic polymer segment comprises a polymer selected from the group consisting of: poly(ethylene oxide) (PEO), poly(methacrylate phosphatidyl choline) (MPC), and polyvinylpyrrolidone (PVP), wherein the hydrophobic polymer segment compriseswherein R′ is —H or —CH, wherein R is —NRR, wherein Rand Rare alkyl groups, wherein Rand Rare the same or different, wherein Rand Rtogether have from 5 to 16 carbons, wherein Rand Rmay optionally join to form a ring, wherein n is 1 to about 10, and wherein x is about 20 to about 200 in total. Also provided are pH-sensitive micelle compositions for therapeutic and diagnostic applications.
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David Allan Boothman from Dallas, TX, age ~66 Get Report