US Patent:
20110086806, Apr 14, 2011
Inventors:
Martha Wild - San Diego CA, US
Katherine S. Bowdish - Del Mar CA, US
Elise Chen - Del Mar CA, US
Daniela Oltean - San Marcos CA, US
Maria Gonzalez - Cardiff CA, US
Mili Kapoor - San Diego CA, US
International Classification:
A61K 38/17
C07H 21/04
C07K 14/47
C07K 19/00
A61P 35/00
A61P 29/00
C40B 30/04
C12N 15/63
C12N 5/10
US Classification:
514 193, 536 231, 530350, 530402, 506 9, 4353201, 435325, 514 206
Abstract:
Polypeptides that bind to IL-23R including polypeptides having a multimerizing, e.g. trimerizing, domain and a polypeptide sequence that binds IL-23R. The multimerizing domain may be derived from human tetranectin. IL-23R binding polypeptides inhibit activation of IL-23R by native IL-23 and can be used as therapeutics agents for a variety of immune related disorders and cancers. Methods for selecting polypeptides and preparing multimeric complexes are described.