US Patent:
20030099992, May 29, 2003
Inventors:
Karl Nocka - Cambridge MA, US
Sun Lu - Potomac MD, US
Quintus Medley - Cambridge MA, US
Daniel Thomis - Marblehead MA, US
Jessie Gu - Waltham MA, US
International Classification:
C12Q001/68
G01N033/53
G01N033/567
A01K067/00
C07H021/04
C12N009/64
C07K014/47
C12P021/02
C12N005/06
US Classification:
435/006000, 800/008000, 435/007200, 435/069300, 435/226000, 435/320100, 435/325000, 530/350000, 536/023200
Abstract:
The invention relates generally to the changes in gene expression in mast cells and tissues removed from patients with allergic hypersensitivity. The invention specifically relates to the genes MC21, MC22, MC25, MC33, MC36, and MC39, which are differentially expressed in mast cells compared to normal tissues and in resting mast cells versus activated mast cells.