Daniel J Cahill

20120261435, Oct 18, 2012

Apr 18, 2011

13/089011

Daniel A. Cahill - Rutherford NJ, US

B65D 83/00
B65G 59/00

221 92, 221282

A container for carrying and dispensing at least one zip tie includes a housing having an outer wall and opposing upper and lower walls defining a substantially hollow interior. An inner wall is formed inside the housing to divide the housing interior into an inner cavity and an outer cavity, and the inner wall has at least one slot formed therein to define a passage between the inner cavity and the outer cavity. A flexible orifice is provided in the upper and lower walls. Another embodiment provides a container for zip ties that also includes a housing having an outer wall and opposing upper and lower walls defining a substantially hollow interior. A dispensing slot formed in the outer wall, and a friction fit passage formed on the outer wall adjacent to the dispensing slot. Yet another embodiment provides a container that combines the features of the first two embodiments.

20210322507, Oct 21, 2021

Jun 30, 2021

17/363897

- Cambridge MA, US
- Boston MA, US
Daniel Cahill - Winchester MA, US
Ganesh Shankar - Brookline MA, US

Massachusetts Institute of Technology - Cambridge MA
The General Hospital Corporation - Boston MA
The Brigham and Women's Hospital, Inc. - Boston MA

A61K 38/00
C12Q 1/6886
A61P 35/00
A61K 47/69
A61K 9/00
A61K 9/51
C12N 9/04
C12N 9/10
C12Q 1/6858

Provided herein are pharmaceutical compositions for local administration of metabolic inhibitors, methods of locally administering such compositions, and rapid diagnostic methods for identifying mutant allele during the course of a surgical procedure.

20190160139, May 30, 2019

Aug 31, 2018

16/119135

- Cambridge MA, US
- Boston MA, US
Daniel Cahill - Winchester MA, US
Ganesh Shankar - Brookline MA, US

A61K 38/00
A61K 9/00
A61K 9/51
A61P 35/00
C12Q 1/6858
C12Q 1/6886
C12N 9/04
C12N 9/10

Provided herein are pharmaceutical compositions for local administration of metabolic inhibitors, methods of locally administering such compositions, and rapid diagnostic methods for identifying mutant allele during the course of a surgical procedure.

20170369939, Dec 28, 2017

Dec 22, 2015

15/538382

MATTHEW MEYERSON - BOSTON MA, US
GANESH M. SHANKAR - BOSTON MA, US
JOSHUA M. FRANCIS - CAMBRIDGE MA, US
DANIEL P. CAHILL - BOSTON MA, US
MIKAEL L. RINNE - BOSTON MA, US
- CAMBRIDGE MA, US
- BOSTON MA, US

THE BROAD INSTITUTE, INC. - CAMBRIDGE MA
DANA-FARBER CANCER INSTITUTE, INC. - BOSTON MA
THE GENERAL HOSPITAL CORPORATION - BOSTON MA

C12Q 1/68

Provided are systems, kits, and methods for the quantitative detection of single nucleotide polymorphisms or variants to identify malignant neoplasms. The methods include use of modified oligonucleotide blockers with peptide nucleic acid backbones that hybridize to and block logarithmic amplification of the wild-type alleles of a target, and incorporation of locked nucleic acids into probes that are complementary to a mutant allele of the target sequence to increase specificity. The methods include detection of variants in sequences with high GC content and/or low complexity, such as the TERT promoter, IDH1, BRAF, NRAS, GNAQ, GNA11 and H3F3 A gene variants. The methods include sensitive detection and staging of cancers with low cellularity, and can be used intraoperatively such as for glioma, or to detect cell-free circulating tumor DNA, such as for melanoma.

20140305966, Oct 16, 2014

Jun 25, 2014

14/314450

Daniel A. Cahill - Rutherford NJ, US

B65D 83/00

221307

A container for carrying and dispensing at least one zip tie includes a housing having a substantially cylindrical outer wall and opposing upper and lower walls defining a substantially hollow interior. A dispensing slot is formed in the outer wall, and a friction fit passage is formed on the outer wall adjacent to the dispensing slot.