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Cyril C Redcrow

from Chula Vista, CA
Age ~59
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Also known as:
Cyril Chung Yuan Redcrow, Cyril Te Redcrow, Cyril Tr Pan, Cryil C Redcrow, Cyril Redcrow Turst, Cyril C Pan
Phone and address:
1855 Plaza Palo Alto, Chula Vista, CA 91914
(619) 500-5185
Related to:
Leonard E Webb, 95Madeline M PanAndria L Catalano, 53Patricia C Catalano, 71Gerard N Catalano, 55Norman C CatalanoChristopher D Webb, 70John C Pan, 93
Connected to:
Adam J Redd, 46Alison P Redd, 55Amelia C Redd, 77Andrew R Redd, 46Anthony C Redd, 67Bea B Redd, 64Britney L Redd, 50Bryan L Redd, 52Carla L Redd, 74Cheraye Y Redd, 37

Cyril Redcrow Phones & Addresses

  • 1855 Plaza Palo Alto, Chula Vista, CA 91914 (619) 500-5185
  • Salinas, CA
  • Santa Ana, CA
  • 4089 Nobel Dr, San Diego, CA 92122 (858) 587-9045
  • 5070 Mansfield St, San Diego, CA 92116
  • Monterey, CA
  • 4089 Nobel Dr APT 27, San Diego, CA 92122 (619) 587-9045

Work

Company: Senomyx, inc. Mar 2001 Position: Associate scientist

Education

Degree: Associate degree or higher

Industries

Biotechnology

Resumes

Resumes

Cyril Redcrow Photo 1

Associate Scientist

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Location:
Chula Vista, CA
Industry:
Biotechnology
Work:
Senomyx, Inc.
Associate Scientist

Publications

Us Patents

Electrophysiological Assay Using Oocytes That Express Human Enac And The Use Phenamil To Improve The Effect Of Enac Enhancers In Assays Using Membrane Potential Reporting Dyes

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US Patent:
20050059094, Mar 17, 2005
Filed:
Jul 9, 2004
Appl. No.:
10/887233
Inventors:
Guy Servant - San Diego CA, US
Hong Chang - San Diego CA, US
Cyril Redcrow - San Diego CA, US
Sumita Ray - San Diego CA, US
Imran Clark - Carlsbad CA, US
International Classification:
G01N033/53
G01N033/567
US Classification:
435007200
Abstract:
In one aspect, the present invention relates to a mammalian cell-based high-throughput assay for the profiling and screening of human epithelial sodium channel (hENaC) cloned from a human kidney c-DNA library and is also expressed in other tissues including human taste tissue. The present invention further relates to amphibian oocyte-based medium-throughput electrophysiological assays for identifying human ENaC modulators, preferably ENaC enhancers. Compounds that modulate ENaC function in a cell-based ENaC assay are expected to affect salty taste in humans. The assays described herein have advantages over existing cellular expression systems. In the case of mammalian cells, such assays can be run in standard 96 or 384 well culture plates in high-throughput mode with enhanced assay results being achieved by the use of a compound that inhibits ENaC function, preferably an amiloride derivative such as Phenamil. In the case of the inventive oocyte electrophysiological assays (two-electrode voltage-clamp technique), these assays facilitate the identification of compounds which specifically modulate human ENaC. The assays of the invention provide a robust screen useful to detect compounds that facilitate (enhance) or inhibit hENaC function. Compounds that enhance or block human ENaC channel activity should thereby modulate salty taste in humans.

Electrophysiological Assays Using Oocytes That Express Human Enac And The Use Of Phenamil To Improve The Effect Of Enac Enhancers In Assays Using Membrane Potential Reporting Dyes

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US Patent:
20090123942, May 14, 2009
Filed:
Jul 9, 2004
Appl. No.:
10/563758
Inventors:
Guy Servant - San Diego CA, US
Hong Chang - San Diego CA, US
Cyril Redcrow - San Diego CA, US
Sumita Ray - San Diego CA, US
Imran Clark - Carlsbad CA, US
Bryan Moyer - San Diego CA, US
International Classification:
C12Q 1/02
G01N 33/554
C12N 5/06
US Classification:
435 721, 435 29, 435325, 435349
Abstract:
In one aspect, the present invention relates to a mammalian cell-based high-throughput assay for the profiling and screening of human epithelial sodium channel (hENaC) cloned from a human kidney c-DNA library and is also expressed in other tissues including human taste tissue. The present invention further relates to amphibian oocyte-based medium-throughput electrophysiological assays for identifying human ENaC modulators, preferably ENaC enhancers. Compounds that modulate ENaC function in a cell-based ENaC assay are expected to affect salty taste in humans. The assays described herein have advantages over existing cellular expression systems. In the case of mammalian cells, such assays can be run in standard 96 or 384 well culture plates in high-throughput mode with enhanced assay results being achieved by the use of a compound that inhibits ENaC function, preferably an amiloride derivative such as Phenamil. In the case of the inventive oocyte electrophysiological assays (two-electrode voltage-clamp technique), these assays facilitate the identification of compounds which specifically modulate human ENaC. The assays of the invention provide a robust screen useful to detect compounds that facilitate (enhance) or inhibit hENaC function. Compounds that enhance or block human ENaC channel activity should thereby modulate salty taste in humans.

Electrophysiological Assays Using Oocytes That Express Human Enac And The Use Of Phenamil To Improve The Effect Of Enac Enhancers In Assays Using Membrane Potential Reporting Dyes

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US Patent:
20120070857, Mar 22, 2012
Filed:
Aug 10, 2011
Appl. No.:
13/206656
Inventors:
Guy Servant - Servant CA, US
Hong Chang - San Diego CA, US
Cyril Redcrow - San Diego CA, US
Sumita Ray - San Diego CA, US
Imran Clark - Carlsbad CA, US
Bryan Moyer - Thousand Oaks CA, US
Assignee:
Senomyx Inc - San Diego CA
International Classification:
C12Q 1/02
C12N 5/10
US Classification:
435 29, 435325, 435366, 435352, 435365, 435357, 435358, 435350
Abstract:
In one aspect, the present invention relates to a mammalian cell-based high-throughput assay for the profiling and screening of human epithelial sodium channel (hENaC) cloned from a human kidney c-DNA library and is also expressed in other tissues including human taste tissue. The present invention further relates to amphibian oocyte-based medium-throughput electrophysiological assays for identifying human ENaC modulators, preferably ENaC enhancers. Compounds that modulate ENaC function in a cell-based ENaC assay are expected to affect salty taste in humans.

Electrophysiological Assays Using Oocytes That Express Human Enac And The Use Of Phenamil To Improve The Effect Of Enac Enhancers In Assays Using Membrane Potential Reporting Dyes

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US Patent:
20190242905, Aug 8, 2019
Filed:
Jan 11, 2019
Appl. No.:
16/245348
Inventors:
- San Diego CA, US
Hong Chang - San Diego CA, US
Cyril REDCROW - San Diego CA, US
Sumita Ray - San Diego CA, US
lmran CLARK - Carlsbad CA, US
Bryan MOYER - San Diego CA, US
International Classification:
G01N 33/68
G01N 33/50
C12Q 1/02
C12N 15/85
Abstract:
In one aspect, the present invention relates to a mammalian cell-based high-throughput assay for the profiling and screening of human epithelial sodium channel (hENaC) cloned from a human kidney c-DNA library and is also expressed in other tissues including human taste tissue. The present invention further relates to amphibian oocyte-based medium-throughput electrophysiological assays for identifying human ENaC modulators, preferably ENaC enhancers. Compounds that modulate ENaC function in a cell-based ENaC assay are expected to affect salty taste in humans. The assays described herein have advantages over existing cellular expression systems. In the case of mammalian cells, such assays can be run in standard 96 or 384 well culture plates in high-throughput mode with enhanced assay results being achieved by the use of a compound that inhibits ENaC function, preferably an amiloride derivative such as Phenamil. In the case of the inventive oocyte electrophysiological assays (two-electrode voltage-clamp technique), these assays facilitate the identification of compounds which specifically modulate human ENaC. The assays of the invention provide a robust screen useful to detect compounds that facilitate (enhance) or inhibit hENaC function. Compounds that enhance or block human ENaC channel activity should thereby-modulate salty taste in humans.

Electrophysiological Assays Using Oocytes That Express Human Enac And The Use Of Phenamil To Improve The Effect Of Enac Enhancers In Assays Using Membrane Potential Reporting Dyes

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US Patent:
20170175160, Jun 22, 2017
Filed:
Sep 6, 2016
Appl. No.:
15/257517
Inventors:
- San Diego CA, US
Hong CHANG - San Diego CA, US
Cyril REDCROW - San Diego CA, US
Sumita RAY - San Diego CA, US
Imran CLARK - Carlsbad CA, US
Bryan MOYER - San Diego CA, US
International Classification:
C12Q 1/02
C12N 15/85
Abstract:
In one aspect, the present invention relates to a mammalian cell-based high-throughput assay for the profiling and screening of human epithelial sodium channel (hENaC) cloned from a human kidney c-DNA library and is also expressed in other tissues including human taste tissue. The present invention further relates to amphibian oocyte-based medium-throughput electrophysiological assays for identifying human ENaC modulators, preferably ENaC enhancers. Compounds that modulate ENaC function in a cell-based ENaC assay are expected to affect salty taste in humans. The assays described herein have advantages over existing cellular expression systems. In the case of mammalian cells, such assays can be run in standard 96 or 384 well culture plates in high-throughput mode with enhanced assay results being achieved by the use of a compound that inhibits ENaC function, preferably an amiloride derivative such as Phenamil. In the case of the inventive oocyte electrophysiological assays (two-electrode voltage-clamp technique), these assays facilitate the identification of compounds which specifically modulate human ENaC. The assays of the invention provide a robust screen useful to detect compounds that facilitate (enhance) or inhibit hENaC function. Compounds that enhance or block human ENaC channel activity should therebymodulate salty taste in humans.
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Cyril C Redcrow from Chula Vista, CA, age ~59 Get Report