Craig A Strathdee

20220226279, Jul 21, 2022

Apr 20, 2020

17/605818

- Leverkusen, DE
- Cambridge MA, US
Antonius ter Laak - Berlin, DE
Ernesto Amaury Fernandez-Montalvan - Le Pecq, FR
Naomi Barak - Berlin, DE
Roman Hillig - Berlin, DE
Roland Neuhaus - Berlin, DE
Matyas Gorjanacz - Berlin, DE
Vera Pütter - Berlin, DE
Stefan Niklaus Gradl - Berlin, DE
Simon Anthony Herbert - Berlin, DE
Steven James Ferrara - Cambridge MA, US
Craig Strathdee - Watertown MA, US
Jacob Jaffe - Cambridge MA, US

A61K 31/343
C07D 307/85
C07D 405/12
C07D 407/12
C07D 405/04
C07D 333/70
C07D 487/04
C07D 413/12
A61K 31/4709
A61K 31/443
A61K 31/351
A61K 31/4025
A61K 31/4525
A61K 31/381
A61K 31/4155
A61K 31/5025
A61K 31/4035
A61K 31/357
A61K 31/4245
A61P 35/00

The present invention provides acyl sulfonamide compounds of general formula (I):

20200179534, Jun 11, 2020

Mar 28, 2018

16/498860

- Cambridge MA, US
- Boston MA, US
Craig Strathdee - Cambridge MA, US

THE BROAD INSTITUTE, INC. - Cambridge MA
DANA-FARBER CANCER INSTITUTE, INC - Boston MA

A61K 48/00
C12N 9/22
C12N 15/11
A61K 38/46
A61K 45/06
C12N 5/09
G01N 33/574

The present disclosure provides compositions and methods for the treatment of PPARG activated cancer. For example, the present disclosure provides PPARG signaling modulators for the treatment of bladder cancer. In particular, therapeutic and/or prophylactic compositions and uses of PPARG inverse-agonists are described.