Craig Kenneth Esser

59729759, Oct 26, 1999

May 22, 1997

8/836953

Craig Esser - Rahway NJ
William Hagmann - Rahway NJ
William Hoffman - Rahway NJ
Shrenik Shah - Rahway NJ
Kenny Wong - Rahway NJ
Renee Chabin - Rahway NJ
Ravindra Guthikonda - Rahway NJ
Malcolm Maccoss - Rahway NJ
Charles Caldwell - Rahway NJ
Philippe Durette - Rahway NJ

Merck & Co., Inc. - Rahway NJ

A61K 3144
C07D21375

514352

Substituted 2-aminopyridine compounds of Formula (I) and pharmaceutically acceptable salts which have been found useful in the treatment of nitric oxide synthase mediated diseases and disorders. ##STR1##.

60907851, Jul 18, 2000

Oct 15, 1992

7/961307

Philippe L. Durette - New Providence NJ
Craig K. Esser - Belford NJ
William K. Hagmann - Westfield NJ
Ihor E. Kopka - Millburn NJ

Merck & Co., Inc. - Rahway NJ

A61K 3805

514 19

Novel N-carboxyalkylpeptidyl compounds represented by the formula ##STR1## which are found to be useful inhibitors of matrix metalloendoproteinases which degrade major components of articular cartilage and basement membranes causing degenerative diseases such as arthritis, periodontal disease, corneal ulceration and the like, and certain cancers, are described.

53590716, Oct 25, 1994

Mar 12, 1993

8/030508

Philippe L. Durette - New Providence NJ
Craig K. Esser - Belford NJ
William Hagmann - Westfield NJ
Ihor E. Kopka - Millburn NJ

Merck & Co., Inc. - Rahway NJ

A61K 31535

546 78

Compounds of the formula ##STR1## or a pharmaceutically acceptable salt or ester thereof, wherein R. sup. 1 is selected from the group consisting of hydrogen and C. sub. 1-10 alkyl; R. sup. 2 is selected from the group consisting of hydrogen and C. sub. 1-10 alkyl; R. sup. 3 is selected from the group consisting of C. sub. 1-10 alkoxyl, C. sub. 1-10 alkyl and cyano; R. sup. 4 is selected from the group consisting of C. sub. 1-10 alkenyloxyl, C. sub. 1-10 alkoxyl, C. sub. 1-10 alkyl, C. sub. 1-10 alkylcarbamic, C. sub. 1-10 alkylcarbonyloxyl, carbonyl, hydroxyl, and --NHR. sup. 5, and R. sup. 5 is selected from the group consisting of hydrogen and C. sub. 1-10 alkylcarbonyl. Such compounds are useful as selective antagonists of testosterone 5. alpha. -reductase 1.

56725833, Sep 30, 1997

May 17, 1995

8/436347

Kevin Chapman - Scotch Plains NJ
William Hagmann - Westfield NJ
Philippe Durette - New Providence NJ
Craig Esser - Belford NJ
Ihor Kopka - Millburn NJ
Charles Caldwell - Scotch Plains NJ

Merck & Co., Inc. - Rahway NJ

A61K 3702
C07C25906
C07C23752
C07D27762

514 19

Novel Carboxy-peptidyl compounds of Formula I are found to be useful inhibitors of matrix metalloendoproteinase-mediated diseases including osteoarthritis, rheumatoid arthritis, septic arthritis, tumor invasion in certain cancers, periodontal disease, corneal ulceration, proteinuria, dystrophobic epidermolysis bullosa, coronary thrombosis associated with atherosclerotic plaque rupture, and aneurysmal aortic disease. The matrix metalloendoproteinases are a family of zinc-containing proteinases including but not limited to stromelysin, collagenase, and gelatinase, that are capable of degrading the major components of articular cartilage and basement membranes. The inhibitors claimed herein may also be useful in preventing the pathological sequelae following a traumatic injury that could lead to a permanent disability. These compounds may also have utility as a means for birth control by preventing ovulation or implantation. ##STR1##.

56938098, Dec 2, 1997

May 12, 1995

8/338571

Philippe L. Durette - New Providence NJ
William Hagmann - Westfield NJ
Gary H. Rasmusson - Watchung NJ
Richard L. Tolman - Warren NJ
Ihor E. Kopka - Millburn NJ
Soumya P. Sahoo - Old Bridge NJ
Craig K. Esser - Belford NJ
Nathan G. Steinberg - Clark NJ
Donald W. Graham - Mountainside NJ
Bruce E. Witzel - Westfield NJ

Merck & Co., Inc. - Rahway NJ

C07D22102
A61K 31435

546 77

Described are new 16-substituted and 7,16-disubstituted 4-aza-5. alpha. -androstan-3-ones and related compounds as 5. alpha. -reductase inhibitors.

59325518, Aug 3, 1999

May 1, 1997

8/848766

Charles G. Caldwell - Scotch Plains NJ
Kevin T. Chapman - Scotch Plains NJ
Craig K. Esser - Keasbey NJ
William K. Hagmann - Westfield NJ
Ihor E. Kopka - Millburn NJ
Scott A. Polo - Yardley PA
Soumya P. Sahoo - Old Bridge NJ
Philippe L. Durette - New Providence NJ

Merck & Co., Inc. - Rahway NJ

A61K 3805

514 19

Novel N-carboxyalkylpeptidyl compounds of formula I are found to be useful inhibitors of matrix metalloendoproteinase-mediated diseases including osteoarthritis, rheumatoid arthritis, septic arthritis, tumor invasion in certain cancers, periodontal disease, corneal ulceration, proteinuria, dystrophobic epidermolysis bullosa, and coronary thrombosis associated with atherosclerotic plaque rupture. The matrix metalloendoproteinases are a family of zinc-containing proteinases including but not limited to stromelysin, collagenase, and gelatinase, that are capable of degrading the major components of articular cartilage and basement membranes. The inhibitors claimed herein may also be useful in preventing the pathological sequelae following a traumatic injury that could lead to a permanent disability. These compounds may also have utility as a means for birth control by preventing ovulation or implantation. ##STR1##.