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Colleen Ryan Siedem

from Longmont, CO
Age ~60
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Also known as:
Colleen R Siedem, Colleen Ann Siedem, Colleen A Siedem, Colleen A Ryan, Christohers Siedem, Chris S Siedem, Chirstoper S Siedem, Colleen Aryan, Siedem Cr
Phone and address:
4215 Redmond Dr, Longmont, CO 80503
(303) 485-5142
Related to:
Michelle L Dorman, 54
Connected to:
Joel D Siedenburg, 43Natalina A Siedentopp, 78Nancy W Sieder, 71Mark J Siedlaczek, 59David L Siedlecki, 78Dean A Siedlecki, 68George R Siedlecki, 61Kelli A Siedlecky, 39Marguerite E Siedlicke, 71Christopher A Siedlik, 51

Colleen Siedem Phones & Addresses

  • 4215 Redmond Dr, Longmont, CO 80503 (303) 485-5142 (303) 682-4395 (720) 249-4078
  • Denver, CO
  • Broomfield, CO
  • Rapid City, SD
  • 705 Meadowbank Rd, Kennett Square, PA 19348 (610) 444-3665
  • Wilmington, DE
  • Burlington, MA
  • Boulder, CO
  • 4215 Redmond Dr, Longmont, CO 80503

Work

Company: Front range community college Position: Adjunct science teaher

Education

Degree: Master of Science (MS) School / High School: UCLA Specialities: Organic Chemistry

Interests

Exercise • Sweepstakes • Home Improvement • Reading • Shooting • Gourmet Cooking • Sports • Golf • Food • Fishing • Home Decoration • Health • Cooking • Gardening • Outdoors • Electronics • Fitness • Collecting • Kids • Medicine • Automobiles • Travel • Boating • Investing • Traveling

Industries

Higher Education

Resumes

Resumes

Colleen Siedem Photo 1

Adjunct Science Teaher

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Location:
4215 Redmond Dr, Longmont, CO 80503
Industry:
Higher Education
Work:
Front Range Community College
Adjunct Science Teaher
Education:
UCLA
Master of Science (MS), Organic Chemistry
Interests:
Exercise
Sweepstakes
Home Improvement
Reading
Shooting
Gourmet Cooking
Sports
Golf
Food
Fishing
Home Decoration
Health
Cooking
Gardening
Outdoors
Electronics
Fitness
Collecting
Kids
Medicine
Automobiles
Travel
Boating
Investing
Traveling

Publications

Us Patents

Benzamide And Sulfonamide Substituted Aminoguanidines And Alkoxyguanidines As Protease Inhibitors

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US Patent:
6274628, Aug 14, 2001
Filed:
Apr 1, 1999
Appl. No.:
9/283241
Inventors:
Richard M. Soll - Lawrenceville NJ
Tianbao Lu - Collegeville PA
Bruce E. Tomczuk - Collegeville PA
Thomas P. Markotan - Morgantown PA
Colleen Siedem - Kennett Square PA
Assignee:
3-Dimensional Pharmaceuticals, Inc. - Exton PA
International Classification:
A61K 31165
A61K 31435
US Classification:
514620
Abstract:
The present invention is directed to aminoguanidine and alkoxyguanidine compounds, including compounds of Formula I: ##STR1## wherein X is O or NH, L is --O-- or --SO. sub. 2 --, and R. sup. 1 -R. sup. 4, R. sup. 9 -R. sup. 19, R. sup. a, R. sup. b, R. sup. c, Y, Z, n and m are set forth in the specification, as well as hydrates, solvates or pharmaceutically acceptable salts thereof, that inhibit proteolytic enzymes such as thrombin. Also described are methods for preparing the compounds of Formula I. Certain of the compounds exhibit antithrombotic activity via direct, selective inhibition of thrombin, or are intermediates useful for forming compounds having antithrombotic activity. The invention includes a composition for inhibiting loss of blood platelets, inhibiting formation of blood platelet aggregates, inhibiting formation of fibrin, inhibiting thrombus formation, and inhibiting embolus formation in a mammal. Other uses of compounds of the invention are as anticoagulants either embedded in or physically linked to materials used in the manufacture of devices used in blood collection, blood circulation, and blood storage.

Benzamide And Sulfonamide Substitued Aminoguanidines And Alkoxyguanidines As Protease Inhibitors

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US Patent:
6344466, Feb 5, 2002
Filed:
Feb 28, 2001
Appl. No.:
09/796319
Inventors:
Richard M. Soll - Lawrenceville NJ
Tianbao Lu - Collegevile PA
Bruce E. Tomczuk - Collegevile PA
Thomas P. Markotan - Morgantown PA
Colleen Siedem - Kennett Square PA
Assignee:
3-Dimensional Pharmaceuticals Inc. - Exton PA
International Classification:
A61K 31445
US Classification:
514331, 5142378, 51421711, 51425212, 51425301, 51425503, 514307, 540607, 544162, 544360, 544386, 544387, 546145, 546226
Abstract:
The present invention is directed to aminoguanidine and alkoxyguanidine compounds, including compounds of Formula I: wherein X is O or NH, L is âOâ or âSO â, and R -R , R -R , R , R , R , Y, Z, n and m are set forth in the specification, as well as hydrates, solvates or pharmaceutically acceptable salts thereof, that inhibit proteolytic enzymes such as thrombin. Also described are methods for preparing the compounds of Formula I. Certain of the compounds exhibit antithrombotic activity via direct, selective inhibition of thrombin, or are intermediates useful for forming compounds having antithrombotic activity. The invention includes a composition for inhibiting loss of blood platelets, inhibiting formation of blood platelet aggregates, inhibiting formation of fibrin, inhibiting thrombus formation, and inhibiting embolus formation in a mammal. Other uses of compounds of the invention are as anticoagulants either embedded in or physically linked to materials used in the manufacture of devices used in blood collection, blood circulation, and blood storage.

Heteroaryl Aminoguanidines And Alkoxyguanidines And Their Use As Protease Inhibitors

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US Patent:
6350764, Feb 26, 2002
Filed:
Apr 6, 2001
Appl. No.:
09/827292
Inventors:
Tianbao Lu - Collegeville PA
Bruce E. Tomczuk - Collegeville PA
Thomas P. Markotan - Morgantown PA
Colleen Siedem - Kennett Square PA
Assignee:
3-Dimensional Pharmaceuticals, Inc. - Exton PA
International Classification:
A61K 314412
US Classification:
514349, 514346, 546293, 546297, 546290, 546291
Abstract:
Aminoguanidine and alkoxyguanidine compounds are described, including compounds of the Formula VII: wherein X is O or NR and Het, R , R , R , R -R , R , R , R , Z, and n are set forth in the specification, as well as hydrates, solvates or pharmaceutically acceptable salts thereof, that inhibit proteolytic enzymes such as thrombin. Also described are methods for preparing such compounds. The compounds of the invention are potent inhibitors of proteases, especially trypsin-like serine proteases, such as chymotrypsin, trypsin, thrombin, plasmin and factor Xa. Certain of the compounds exhibit antithrombotic activity via direct, selective inhibition of thrombin. The invention includes a composition for inhibiting loss of blood platelets, inhibiting formation of blood platelet aggregates, inhibiting formation of fibrin, inhibiting thrombus formation, and inhibiting embolus formation in a mammal, comprising a compound of the invention in a pharmaceutically acceptable carrier. Other uses of compounds of the invention are as anticoagulants either embedded in or physically linked to materials used in the manufacture of devices used in blood collection, blood circulation, and blood storage, such as catheters, blood dialysis machines, blood collection syringes and tubes, blood lines and stents. Additionally, the compounds can be detectably labeled and employed for in vivo imaging of thrombi.

Heteroaryl Aminoguanidines And Alkoxyguanidines And Their Use As Protease Inhibitors

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US Patent:
6472399, Oct 29, 2002
Filed:
Dec 12, 2001
Appl. No.:
10/012445
Inventors:
Tianbao Lu - Collegeville PA
Bruce E. Tomczuk - Collegeville PA
Thomas P. Markotan - Morgantown PA
Colleen Siedem - Kennett Square PA
Assignee:
3-Dimensional Pharmaceuticals, Inc. - Exton PA
International Classification:
A61K 3144
US Classification:
51425505, 51425506, 514349, 544120, 544405, 544408
Abstract:
Aminoguanidine and alkoxyguanidine compounds are described, including compounds of the Formula VII: wherein X is O or NR and Het, R , R , R , R -R , R , R , R , Z, and n are set forth in the specification, as well as hydrates, solvates or pharmaceutically acceptable salts thereof, that inhibit proteolytic enzymes such as thrombin. Also described are methods for preparing such compounds. The compounds of the invention are potent inhibitors of proteases, especially trypsin-like serine proteases, such as chymotrypsin, trypsin, thrombin, plasmin and factor Xa. Certain of the compounds exhibit antithrombotic activity via direct, selective inhibition of thrombin. The invention includes a composition for inhibiting loss of blood platelets, inhibiting formation of blood platelet aggregates, inhibiting formation of fibrin, inhibiting thrombus formation, and inhibiting embolus formation in a mammal, comprising a compound of the invention in a pharmaceutically acceptable carrier. Other uses of compounds of the invention are as anticoagulants either embedded in or physically linked to materials used in the manufacture of devices used in blood collection, blood circulation, and blood storage, such as catheters, blood dialysis machines, blood collection syringes and tubes, blood lines and stents. Additionally, the compounds can be detectably labeled and employed for in vivo imaging of thrombi.

Heteroaryl Aminoguanidines And Alkoxyguanidines And Their Use As Protease Inhibitors

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US Patent:
6566379, May 20, 2003
Filed:
Sep 12, 2002
Appl. No.:
10/241513
Inventors:
Tianbao Lu - Kennett Square PA
Bruce E. Tomczuk - Collegeville PA
Thomas P. Markotan - Morgantown PA
Colleen Siedem - Kennett Square PA
Assignee:
3-Dimensional Pharmaceuticals, Inc. - Exton PA
International Classification:
A61K 314412
US Classification:
514345, 514351, 514357, 546300, 546329, 546340
Abstract:
Aminoguanidine and alkoxyguanidine compounds are described, including compounds of the Formula VII: wherein X is O or NR and Het, R , R , R , R -R , R , R , R , Z, and n are set forth in the specification, as well as hydrates, solvates or pharmaceutically acceptable salts thereof, that inhibit proteolytic enzymes such as thrombin. Also described are methods for preparing such compounds. The compounds of the invention are potent inhibitors of proteases, especially trypsin-like serine proteases, such as chymotrypsin, trypsin, thrombin, plasmin and factor Xa. Certain of the compounds exhibit antithrombotic activity via direct, selective inhibition of thrombin. The invention includes a composition for inhibiting loss of blood platelets, inhibiting formation of blood platelet aggregates, inhibiting formation of fibrin, inhibiting thrombus formation, and inhibiting embolus formation in a mammal, comprising a compound of the invention in a pharmaceutically acceptable carrier. Other uses of compounds of the invention are as anticoagulants either embedded in or physically linked to materials used in the manufacture of devices used in blood collection, blood circulation, and blood storage, such as catheters, blood dialysis machines, blood collection syringes and tubes, blood lines and stents. Additionally, the compounds can be detectably labeled and employed for in vivo imaging of thrombi.

Heteroaryl Aminoguanidines And Alkoxyguanidines And Their Use As Protease Inhibitors

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US Patent:
6706021, Mar 16, 2004
Filed:
Mar 27, 2003
Appl. No.:
10/400073
Inventors:
Tianbao Lu - Kennett Square PA
Bruce E. Tomczuk - Collegeville PA
Thomas P. Markotan - Morgantown PA
Colleen Siedem - Kennett Square PA
Assignee:
3-Dimensional Pharmaceuticals, Inc. - Exton PA
International Classification:
A61M 514
US Classification:
604244, 514345, 514351, 51425505, 51425506, 546300, 546329, 546345, 546357, 544120, 544405, 544408
Abstract:
Aminoguanidine and alkoxyguanidine compounds are described, including compounds of the Formula VII: wherein X is O or NR and Het, R , R , R , R -R R , R , R , Z, and n are set forth in the specification, as well as hydrates, solvates or pharmaceutically acceptable salts thereof, that inhibit proteolytic enzymes such as thrombin. Also described are methods for preparing such compounds. The compounds of the invention are potent inhibitors of proteases, especially trypsin-like serine proteases, such as chymotrypsin, trypsin, thrombin, plasmin and factor Xa. Certain of the compounds exhibit antithrombotic activity via direct, selective inhibition of thrombin. The invention includes a composition for inhibiting loss of blood platelets, inhibiting formation of blood platelet aggregates, inhibiting formation of fibrin, inhibiting thrombus formation, and inhibiting embolus formation in a mammal, comprising a compound of the invention in a pharmaceutically acceptable carrier. Other uses of compounds of the invention are as anticoagulants either embedded in or physically linked to materials used in the manufacture of devices used in blood collection, blood circulation, and blood storage, such as catheters, blood dialysis machines, blood collection syringes and tubes, blood lines and stents. Additionally, the compounds can be detectably labeled and employed for in vivo imaging of thrombi.

Heteroaryl Aminoguanidines And Alkoxyguanidines And Their Use As Protease Inhibitors

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US Patent:
7029654, Apr 18, 2006
Filed:
Nov 17, 2003
Appl. No.:
10/714988
Inventors:
Tianbao Lu - Collegeville PA, US
Bruce E. Tomczuk - Collegeville PA, US
Thomas P. Markotan - Morgantown PA, US
Colleen Siedem - Kennett Square PA, US
Assignee:
Ortho-McNeil Pharmaceuticals, Inc. - Raritan NJ
International Classification:
A61K 49/00
US Classification:
424 91, 424 111, 424 165, 514349, 546297
Abstract:
Aminoguanidine and alkoxyguanidine compounds are described, including compounds of the Formula VII: wherein X is O or NRand Het, R, R, R, R—R, R, R, R, Z, and n are set forth in the specification, as well as hydrates, solvates or pharmaceutically acceptable salts thereof, that inhibit proteolytic enzymes such as thrombin. Also described are methods for preparing such compounds. The compounds of the invention are potent inhibitors of proteases, especially trypsin-like serine proteases, such as chymotrypsin, trypsin, thrombin, plasmin and factor Xa. Certain of the compounds exhibit antithrombotic activity via direct, selective inhibition of thrombin. The invention includes a composition for inhibiting loss of blood platelets, inhibiting formation of blood platelet aggregates, inhibiting formation of fibrin, inhibiting thrombus formation, and inhibiting embolus formation in a mammal, comprising a compound of the invention in a pharmaceutically acceptable carrier. Other uses of compounds of the invention are as anticoagulants either embedded in or physically linked to materials used in the manufacture of devices used in blood collection, blood circulation, and blood storage, such as catheters, blood dialysis machines, blood collection syringes and tubes, blood lines and stents. Additionally, the compounds can be detectably labeled and employed for in vivo imaging of thrombi.

Heteroaryl Aminoguanidines And Alkoxyguanidines And Their Use As Protease Inhibitors

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US Patent:
7402586, Jul 22, 2008
Filed:
Oct 19, 2005
Appl. No.:
11/254086
Inventors:
Tianbao Lu - Collegeville PA, US
Bruce Tomczuk - Collegeville PA, US
Thomas P. Markotan - Morgantown PA, US
Colleen Siedem - Kennett Square PA, US
Assignee:
Ortho-McNeil Pharmaceutical, Inc. - Raritan NJ
International Classification:
C07D 239/54
A61K 31/513
US Classification:
514269, 544309, 544319
Abstract:
Aminoguanidine and alkoxyguanidine compounds are described, including compounds of the Formula VII:.
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Colleen Ryan Siedem from Longmont, CO, age ~60 Get Report