US Patent:
20160313304, Oct 27, 2016
Inventors:
- Pasadena CA, US
Colleen A. McHugh - Altadena CA, US
International Classification:
G01N 33/50
Abstract:
Methods of prohibiting Xist-dependent silencing of X chromosome genes include targeting the required Xist silencing complex components including SHARP, SMRT, HDAC3, SAF-A, LBR, and the respective binding sites of SHARP, LBR, and SAF-A on Xist, thereby prohibiting Xist repression, allowing for reactivation of the silenced X chromosome genes.
