Clark H Galen

20110008458, Jan 13, 2011

Jul 9, 2009

12/459911

James Gandy - Calhoun LA, US
Robert J. Brandt - Ft. Myers FL, US
Ryan N. Brandt - Cape Coral FL, US
Clark Galen - Osprey FL, US
Joseph Greco - Sarasota FL, US
John Kiwczak - Sarasota FL, US

A61K 35/16
C07K 1/14
A61K 38/18
A61P 17/02

424530, 530412, 514 82, 514 94

A sub-atmospheric, negative pressure is applied to a growth factor starting material, such as whole blood, to release growth factors and plasma in a non-destructive medium. The released growth factors having a weight of about 70-76 kDaltons are applied in either a filtered or unfiltered state to a wound to promote healing of the wound. The released growth factors are applied topically to the area of a surface wound to effect healing. The released growth factors are also injected into soft tissue, such as a torn tendon, to promote tissue growth and healing. The growth factors are released in one method from a patient's own blood. In another method the growth factors are released from a whole blood source and freeze dried by conventional lyophilization. Then at a later date, the freeze dried product is reconstituted by normal saline for treatment of a patient's wound or for use in a surgical procedure.

20180133256, May 17, 2018

Sep 9, 2017

15/700084

Gary H. Nelson - Fort Myers FL, US
Ryan N. Brandt - Fort Myers FL, US
Clark Galen - Sarasota FL, US
John Kiwczak - Sarasota FL, US

PGFX Patent Holdings, LLC - West Monroe LA

A61K 35/19
A61K 47/42
A61K 38/18
C12N 1/06

In vitro and in vivo application of sub-atmospheric, negative pressure on growth factor starting material, such as whole blood, extracts growth factors from the platelet granules of the growth factor starting material in a non-destructive medium without activating the clotting process. The extracted growth factors are released into a growth factor composition containing blood plasma, extracellular fluid or interstitial fluid depending upon the type and location of the growth factor starting material. The growth factors have a weight of about 70-76 kDaltons and are applied in either a filtered or unfiltered state topically to the area of a surface wound to effect healing. The extracted growth factors are also injected into soft tissue, such as a torn tendon, to promote tissue growth and healing. The growth factors are released in one method from a patient's own blood. In another method the growth factors are released from a whole blood source and freeze dried by lyophilization. Then at a later date, the freeze-dried product is reconstituted by normal saline for treatment of a patient's wound, for use in a surgical procedure, or for tissue regeneration.