US Patent:
20030181470, Sep 25, 2003
Inventors:
Paul Ala - Newark DE, US
Janid Ali - Waltham MA, US
Jacob Clement - Vancouver MA, US
Patrick Connelly - Harvard MA, US
Carlos Faerman - Acton MA, US
Christopher Farady - San Francisco CA, US
John Gazzaniga - Worcester MA, US
Andrew Magee - Maynard MA, US
Salvatore Marchese - Malden MA, US
Scott Moe - Marlborough MA, US
Manuel Navia - Lexington MA, US
Emanuele Perola - Cambridge MA, US
Paul Will - Stoneham MA, US
International Classification:
A61K031/519
A61K031/517
C07D487/02
C07D239/95
US Classification:
514/262100, 514/264110, 514/266400, 544/256000, 544/279000, 544/291000
Abstract:
The invention is based on the discovery of a new class of heterocyclic compounds having, for example, antibacterial properties. The D-Ala-D-Ala ligase enzyme is a critical pathway enzyme in the bacterial cell-wall synthesis. The compounds can bind to and inhibit the enzyme D-Ala-D-Ala ligase. The new compounds' activity combined with their ability to cross bacterial cell membranes makes them suitable for use as antibacterial drugs or other antibacterial applications.