US Patent:
20040235817, Nov 25, 2004
Inventors:
Karel Brands - Jersey City NJ, US
Raymond Cvetovich - Scotch Plains NJ, US
Louis Crocker - Belle Mead NJ, US
Michael Ward - Westfield NJ, US
Amar Mahajan - Piscataway NJ, US
Robert Wenslow - East Windsor NJ, US
John Williams - Hillsborough NJ, US
Daniel Sidler - Whitehouse Station NJ, US
Charles Orella - Whitehouse Station NJ, US
Elizabeth Fisher - Cranbury NJ, US
International Classification:
A61K031/41
C07D487/04
Abstract:
A process for preparing a crystalline, carbapenem monosodium salt of formula IIa: characterized by the steps a) adding about 10 to 30% of an organic solvent to an aqueous solution of the carbapenem, b) cooling the resulting solution to less than -5 C., c) adjusting the pH using a solution containing an acid in an organic solvent to give the appropriate pH for crystallization, and d) crystallizing the compound by adding methanol, and a Calcohol at between -5 and -25 C.