Inventors:
Irina Neagu - Plainsboro NJ, US
David Diller - East Windsor NJ, US
Celia Kingsbury - Cream Ridge NJ, US
Adolph C. Bohnstedt - Burlington NJ, US
Michael J. Ohlmeyer - Plainsboro NJ, US
Vidyadhar Paradkar - Somerville NJ, US
Nasrin Ansari - Monmouth Junction NJ, US
International Classification:
C07D 473/32
C07D 473/18
A61K 31/52
A61K 31/522
A61P 37/06
A61P 11/06
A61P 35/02
C07D 239/48
C07D 239/50
C07D 405/12
C07D 405/14
US Classification:
5142285, 5142342, 51421115, 51421706, 51425216, 51426321, 5142632, 51426322, 51426324, 540575, 540600, 544 61, 544 81, 544276, 544277, 544321, 544323, 544324, 544326, 544328, 544332, 549396, 549399, 549404
Abstract:
The present invention provides novel purinones and purines useful for the prevention and treatment of autoimmune diseases, inflammatory disease, mast cell mediated disease and transplant rejection. The compounds are of the general formulae I and II shown below, in which Q is selected from the group consisting of CX and nitrogen; and A is chosen from the group consisting of H, (C-C) alkyl, heteroaryl, and aryl:.