Thomas E. Hughes - Bozeman MT,
Robert G. Mealer - Bozeman MT,
Catherine H. Berlot - Sunbury PA,
506 9, 435 6, 536 234, 530350
A method of detecting protein interactions is described wherein reporter protein fragments are genetically fused at internal positions of suspected interacting proteins. When proteins interact, the fluorescent fragments are brought close enough together to form a functional reporter protein providing visible confirmation of interaction.