Inventors:
Dimitri Gaitanopoulos - Eagleville PA
Bruce Mico - Bridgewater NJ
Joseph Weinstock - Phoenixville PA
Assignee:
SmithKline Beckman Corporation - Philadelphia PA
International Classification:
C07D22316
A61K 3155
Abstract:
Prodrug carbamate derivatives of fenoldopam which provide fenoldopam plasma levels of similar magnitude and over a much longer period of time than the parent compound. An absence of a high initial peak effect associated with the parent compound is noted. A lead compound of the series is 6-chloro-7,8-diethylcarbamoyl-1-(4'-ethylcarbamoylphenyl)-2,3,4,5-tetrahyd ro-1H-3-benzazepine. The R-enantiomers are the most biologically active and preferred compounds.